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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine显示文摘由几抗原组成的多价的疫苗的发展是对不同寄生虫紧张和寄生虫生命周期阶段创造宽广范围的保护的一条新奇途径。我们以前证实了血吸虫 Sm21.7 和 Sm Fimbrin (SmFim ) 蛋白质能在老鼠导致保护。因此,这研究试图构造多价的 DNA 疫苗的 Sm21.7-SmFim/pBudCE4.1 并且评估它的有免疫力的功效。二血吸虫 mansoni 基因, Sm21.7 和 SmFim 的开的读物框架,被插入到为独立人士设计的真核细胞的表示原生质标志 pBudCE4.1 在哺乳动物的房间的二基因的表示。评估在里面在老鼠的多价的 Sm21.7-SmFim/pBudCE4.1 DNA 疫苗和它的免疫学的效果的 vitro 表示, recombinant 原生质标志 Sm21.7-SmFim/pBudCE4.1 习惯于 mRNA 的 transfect 293T 房间,和表示,蛋白质用反向的抄写聚合酶链反应和蛋白质印迹分析被检验。然后 Sm21.7-SmFim/pBudCE4.1 到的能力免于 S。mansoni 挑战感染在老鼠的种痘以后根据蠕虫负担和鸡蛋减小率被分析。种牛痘的老鼠出现了保护(56%) 的重要水平,和在数字和尺寸的减少,和在细胞的侧面的变化, granulomas。分别地,在肝和肠的鸡蛋减小是 41.53% 和 55.63% 相对仅仅收到了空向量的老鼠同样坚定。除了在蠕虫生存能力的减小,蠕虫肥沃和鸡蛋孵化能力被观察在使免疫的组跟随挑战感染。结果证明 Sm21.7-SmFim/pBudCE4.1 能表示 Sm2 1.7 和 SmFim mRNA 和蛋白质。连接酶的免疫吸着剂试金和蛋白质印迹分析显示使免疫的老鼠对 Sm21.7-SmFim/pBudCE4.1 产生了特定的免疫球蛋白 G。这些结果与多价的 S 建议那种痘。mansoni DNA 疫苗(SmFim-Sm21.7/pBudCE4.1 ) 不仅在蠕虫和卵负担导致重要减小,而且显著地减少卵 granulomas 的尺寸。在摘要,多价的疫苗与保护的重要水平刺激了特定的免疫并且反病理学的效果。 | Mahmoud H Romeih Hanem M Hassan Tarek S Abou Shousha Mohamed A Saber | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 3 |
| 3 | Minimum thickness of a flowing down liquid film on a vertical surface 显示文摘 | Mohamed S Genk E I Hamed H Saber | 2001 | International Journal of Heat and Mass Transfer2001，44，： | 1 |
| 4 | Survey of contemporary trends in color image segmentation 显示文摘 | VANTARAM S R SABER E | 2012 | Journal of Electronic Imaging2012，21，4： | 1 |
| 5 | Pulse current dec- trodeposition of a nocrystalline zine显示文摘 | Saber K H Koch C C Fedkiw P S | 2003 | Materials Sci- ence and Engineering2003，341，12： | 1 |
| 6 | Pulse current electrodeposition of nanocrystalline zinc显示文摘 | Saber K H Koch C C Fedkiw P S | 2003 | Materials Science and Engineering2003，341，： | 1 |
| 7 | Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics显示文摘 | Holst AG Saber S Houshmand M | 2012 | Can J Cardiol2012，28，2： | 1 |
| 8 | Pulse current electrodeposition of nanocrystalline zine显示文摘 | Saber K H Koch C C Fedkiw P S | 2003 | Materials Science and Engineering A2003，341，12： | 1 |
| 9 | Hepatic andpulmonary toxicogenomic profiles in mice intratracheally instilledwith carbon black nanoparticles reveal pulmonary inflammation,acute phase response,and alterations in lipid homeostasis显示文摘 | Bourdon JA Halappanavar S Saber AT | 2012 | Toxicol Sci2012，127，2： | 1 |
| 10 | Influence of the thickness of matching layers on narrow band transmitter ultrasonic airborne transducers with frequencies<100kHz:application of a genetic algorithm显示文摘 | SABER S AMIR A RAMZI O | 2014 | Applied Acoustics2014，75，： | 1 |
| 11 | Impact ofβ-globin mutations on outcome of matched related donor hematopoietic stem cell transplantation for patients withβ-Thalassemia Major显示文摘 | Hamidieh AA Saber T Fayyazi S | 2014 | Biol Blood Marrow Transplant2014，，20： | 1 |
| 12 | Carbon blacknanoparticle intratracheal installation results in large and sustainedchanges in the expression of miR-135b in mouse lung显示文摘 | Bourdon JA Saber AT Halappanavar S | 2012 | Environ Mol Mutagen2012，53，6： | 1 |
| 13 | Survey of contemporary trends in color image segmentation 显示文摘 | VANTARAM S R SABER E | 2012 | Journal of Electronic Imaging2012，21，4： | 1 |
| 14 | Flexor Tendon Tissue Engineering:Bioreactor Cyclic Strain Increases Construct Strength显示文摘 | Saber S Zhang AY Ki SH | | 0，，06： | 1 |
| 15 | Brain stem andcerebellar findings in Joubert syndrome显示文摘 | Alorainy IA Saber S Seidahmad MZ | 2006 | J Com put AssistTomogr2006，30，1： | 1 |
| 16 | Flexor Tendon Tissue Engineering:Temporal Distribution of Donor Tenocytes versus Recipient Cells显示文摘 | Thorfinn J Saber S Angelidis IK | | 0，，06： | 1 |
| 17 | Natural orifice translumenal endoscopic surgery (NOTES) 显示文摘 | Song S Itawi EA Saber AA | 2009 | J Invest Surg2009，22，3： | 1 |
| 18 | Two novel very small monopole antennas having frequency band notch function using DGS for UWB application 显示文摘 | SABER S MOHAMMADNAGHI A PARISA L | 2011 | Journal of Electronic Communication2011，65，1： | 1 |
| 19 | Effect of Non-surgical Periodontal Therapy on Serum and Salivary Concentrations of Visfatin in Patients with Chronic Periodontitis 显示文摘 | Abolfazli N Jabali S Saleh Saber F | 2015 | J Dent Res DentClin Dent Prospects2015，9，1： | 1 |
| 20 | Complex genetic background in a large family with Brugada syndrome显示文摘 | Saber S Amarouch MY Fazelifar AF | 2015 | Physiol Rep2015，3，12： | 1 |
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