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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Minimum thickness of a flowing down liquid film on a vertical surface 显示文摘 | Mohamed S Genk E I Hamed H Saber | 2001 | International Journal of Heat and Mass Transfer2001，44，： | 1 |
| 3 | Angiogenesis as an indicator of metastatic potential in papillary thyroid carcinoma显示文摘 | Stabenow E Tavares MR Ab' Saber AM | 2005 | Clinics2005，60，3： | 1 |
| 4 | Survey of contemporary trends in color image segmentation 显示文摘 | VANTARAM S R SABER E | 2012 | Journal of Electronic Imaging2012，21，4： | 1 |
| 5 | Hierarchical Watermarking for Secure Image Authentication with Localization显示文摘 | Celik M U Sharma G Saber E | 2002 | IEEE Trans on Image Processing2002，11，6： | 1 |
| 6 | Hierarchical watermarking for secure image authentication with localization显示文摘 | Celik M U Sharma G Saber E | 2002 | IEEE Transactions on Image Processing2002，11，6： | 1 |
| 7 | Hierarchical watermarking for secure image authentication with localization显示文摘 | Celik M U Sharma G Saber E | 2002 | IEEE Transactions on Image Processing2002，11，6： | 1 |
| 8 | Hierarchical watermarking for secure image authentication with localization显示文摘 | Celik M U Sharma G Saber E | 2002 | IEEE Tmns on Image Processing2002，11，6： | 1 |
| 9 | Automated extraction of fire line parameters from multispectral infrared images显示文摘 | Ononye A E Vodacek A Saber E | 2007 | Remote Sensing of Environment2007，108，： | 1 |
| 10 | Single-incision laparoscopic sleeve gaslrectomy (SILS): a novel technique 显示文摘 | Saber A Elgamal M llawi E Rao A | 2008 | Obes Surg2008，1800，： | 1 |
| 11 | Survey of contemporary trends in color image segmentation 显示文摘 | VANTARAM S R SABER E | 2012 | Journal of Electronic Imaging2012，21，4： | 1 |
| 12 | A new approach for immobilization of oligonucleotides onto piezoelectric quartz crystal for preparation of a nucleic acid sensor for following hybridization显示文摘 | Duman M Saber R Piskin E | 2003 | Biosens Bioelectron2003，18，11： | 1 |
| 13 | Color image generation and display technology显示文摘 | VRHEL M SABER E TRUSSELL H J | 2008 | IEEE2008，22，22： | 1 |
| 14 | An adaptive classifi-cation system for video-based face recognition 显示文摘 | Connolly J F Granger E Sabering R | 2012 | Infor-mation Sciences2012，192，： | 1 |
| 15 | Comparative evaluation of the shaping ability of Pro Taper Next,iRa Ce and Hyflex CM rotary NiTi files in severely curved root canals显示文摘 | Saber SE Nagy MM Schfer E | 2015 | Int Endod J2015，48，2： | 1 |
| 16 | Chronic ammonia toxicity to duckweed-fed tilapia(Oreochromis niloticus)显示文摘 | Saber A E Fayza A N | 2004 | Aquaculture2004，，232： | 1 |
| 17 | Hierarchical watermarking for secure image authentication with localization显示文摘 | CELIK M SHARMA G SABER E | 2002 | IEEE Transactions on Image Processing2002，11，6： | 1 |
| 18 | Hierarchical watermarking for secure image authentication with localization 显示文摘 | Celik M U Sharma G Saber E | 2002 | IEEE Transactions on Image Processing2002，11，6： | 1 |
| 19 | Frontal-view face detection and facial feature extraction using color, shape, symmetry based cost functions显示文摘 | Saber E Tekalp | 1998 | Pattern Recognition Letters1998，，19： | 1 |
| 20 | Fusion of color and edge information for improved segmentation and edge linking显示文摘 | Saber E Tekalp A M Bozdagi G | 1997 | Image and Vision Computing1997，15，10： | 1 |
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