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| 1 | The andropause and memory loss: is there a link between androgen decline and dementia in the aging male?显示文摘Studies demonstrate a decline in androgens with age and this results in the andropause. The objective of this paper is to review the literature on hormonal changes that occur in the aging males and determine if there are associations between decreased testosterone, dehydroepiandrosterone (DHEA) and decreased cognitive function. Trials of androgen replacement and its impact on cognitive function will also be analyzed. Method of analysis will be by a thorough search of articles on MEDLINE, the Intemet and major abstract databases. Results of the author's own research in 302 men of the association of memory loss as a symptom in the andropause will be presented. In addition, the authors open trial of testosterone replacement in hypogonadic men with Alzheimer's disease will also be presented. The results of the author's trial will be compared with other investigators. High endogenous testosterone level predicted better performance on visual spatial tests in several studies, but not in all studies. Likewise, testosterone replacement in hypogonadic patients improved cognitive functions in some but not all studies. Testosterone has also been shown to improve cognitive function in eugonadal men. Several studies have shown that declines in DHEA may contribute to Alzheimer's disease and the results of double blind studies with DHEA replacement and its effect on cognition will also be presented. In summary, there is still no consensus that androgen replacement is beneficial in cognitive decline but this option may prove promising in some patients. | Robert S.Tan Shou-Jin Pu | 2001 | Asian Journal of Andrology2001，3，3： | 11 |
| 2 | FACTORS AFFECTING EARLY MORTALITY IN SPONTANEOUS RUPTURE OF HEPATOCELLULAR CARCINOMA显示文摘 | Felicia L.‐S.Tan Yu‐MengTan Alexander Y.‐F.Chung Peng C.Cheow Pierce K.‐H.Chow London L.Ooi | 2006 | ANZ Journal of Surgery2006，，6： | 2 |
| 3 | Validation of Authentic Reasoning Expert Systems显示文摘 | Laurie Webster II Jen-Gwo Chen Simon S.Tan | | 0，，： | 1 |
| 4 | Cytochrome P450 3A4 genetic polymorphisms and post‐operative fentanyl requirements显示文摘 | P. C. S.Tan S. K.Hassan N. A. N.Mohamad S. H.Gan | 2012 | Journal of Clinical Pharmacy and Therapeutics2012，，1： | 1 |
| 5 | Adult intussusception: experience in Singapore显示文摘 | Kok YangTan Su‐MingTan Andrew G. S.Tan Cosmos Y. Y.Chen Hong‐CheeChng Michael N. Y.Hoe | 2003 | ANZ Journal of Surgery2003，，12： | 1 |
| 6 | Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an enveloped RNA betacoronavirus,1 that has spread globally since December 2019.As of July 22,2020,more than 14,000,000 confirmed cases and 607,781 deaths from COVID-19 have been reported to the World Health Organization from 216 areas and territories.2 Patientswithmore prominent laboratory abnormalities may develop acute respiratory distress syndrome(ARDS),which potentially leads tomultiple organ failure and death.1,3 However,at present,there are no regulatory approved antiviralmedicines,vaccines,or specific clinical treatments for COVID-19. | Junping Wu Cherie S.Tan Hongzhi Yu Youwei Wang Yutao Tian Wenwei Shao Yifei Zhang Kuo Zhang Hongxia Shao Guangjian Ni Jun Shen Antonio Carlo Galoforo Qi Wu Dong Ming | 2020 | The Innovation2020，1，3： | 1 |
| 7 | Antioxidant,cytotoxic,and anti-venom activity of Alstonia parvifolia Merr.Bark显示文摘Objective:To evaluate antioxidant,cytotoxic,and anti-venom capacity of crude bark extracts of Alstonia parvifolia Merr.Methods:Gas chromatography-mass spectrometry(GC-MS)and energy dispersive X-ray analyses were accomplished to characterize the chemical constituents of Alstonia parvifolia.Biochemical characterization was evaluated using an inhibitory phospholipase A_(2)(PLA_(2))assay,DPPH,and cytotoxicity assays.Using the constituents listed in the GC-MS analyses,molecular docking was conducted to inspect the binding energies between the chosen compounds and selected PLA_(2) isoforms.Results:GC-MS analyses showed that the Alstonia parvifolia crude extract consisted predominantly of acetylmarinobufogenin(14.89%),γ-sitosterol(10.44%),3-O-methyl-D-glucose(5.88%),3,5-dimethoxy-4-hydroxyphenylacetic acid(5.30%),(2α,5α)-17-methoxyaspidofractinin-3-one(AFM)(4.08%),and 2,3,5,6,7,8,9-heptahydro-1-phenyl-5-(p-chlorophenylimino)-1H-benzo[e][1,4]thiazepine(HPT)(1.37%).The principal elemental components of Alstonia parvifolia were Ca(4.012%)and K(1.496%),as exhibited by energy dispersive X-ray examination.Alstonia parvifolia showed significant free radical scavenging ability(IC_(50):0.287 mg/mL)and was non-cytotoxic to normal HDFn cells(IC_(50)>100μg/mL).Moreover,Alstonia parvifolia was favorably cytotoxic to MCF-7(IC_(50):4.42µg/mL),followed by H69PR,HT-29,and THP-1,with IC_(50) values of 4.94,5.07,and 6.27µg/mL,respectively.Alstonia parvifolia also displayed notable inhibition against PLA_(2) activity of Naja philippinensis Taylor venom with IC_(50) of(15.2±1.8)μg/mL.Docking and cluster analyses projected negative binding energies from AFM(−6.36 to−9.68 kcal/mol),HPT(−7.38 to−9.77 kcal/mol),and acetylmarinobufogenin(−7.22 to−9.59 kcal/mol).These calculations were for the particular interactions of Alstonia parvifolia constituents to PLA_(2) homologues where the utmost affinity was detected in HPT owing to the dipole interactions with amino acid residues.Conclusions:The bark extract of Alstonia parvifolia shows great potential as an anti-venom agent due to its low cytotoxic profile,remarkable PLA_(2) inhibition,and docking binding energies between its bioactive constituents and PLA_(2) homologues. | Maria Carmen S.Tan Mary Stephanie S.Carranza Virgilio C.Linis Raymond S.Malabed Yves Ira A.Reyes Francisco C.Franco,Jr. Glenn G.Oyong | 2021 | Asian Pacific Journal of Tropical Biomedicine2021，11，10： | 0 |
| 8 | 绝雄期和记忆缺失:老年男子雄激素降低与痴呆是否关联?显示文摘研究表明雄激素分泌的随龄降低,导致绝雄期。本文通过对MEDLINE,国际互联网和主要医学文摘数据库的广泛检素,就老年男子的激素分泌变化作一综述,并探讨睾酮和脱氢表雄酮的降低与其认知功能衰退的联系;亦将分析雄激素补充对认知功能的影响。本文同时将报道作者对302位男子,所作的记忆缺失与绝雄期关联的研究,以及睾酮替代疗法对性腺机能减退的阿尔茨海默氏病患者临床试用结果,并将作者的结果与其它研究人员的结果相比较。1、在某些研究中,体内睾酮水平较高者视觉空间试验表现良好。同样,在部分性腺功能减退患者,睾酮替代疗法改善其认知功能,此外,在性腺功能正常的男性患者,睾酮对认知功能亦有一定的改善。2、一些试验表明,脱氢表雄酮降低可能有助于阿尔茨海默氏病的发生。文中也将介绍脱氢表雄酮替代疗法对认知功能影响的双盲试验结果。结论:雄激素替代疗法是否有助于阻止认知功能下降目前还未达成共识,但对部分病人可能有一定前景。 | Robert S.Tan Shou-Jin Pu | 2002 | 生殖与避孕2002，22，1： | 0 |
| 9 | Comment on visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery显示文摘Dear Editor,We read with interest the article by Chen et al[1]on the visual impact of sub-Tenon anesthesia during combined phacoemulsification and vitrectomy surgery.The authors reported that 93.3%of patients in the study experienced loss of perception of light at least during one of the surgical steps after the contralateral eye was covered intraoperatively[1].Most of the patients(81%)reported | Kelvin Z.Li Colin S.Tan | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 0 |
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