|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury显示文摘Traumatic brain injury(TBI)poses a significant socioeconomic burden in the world.The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear.In this perspective,cholinergic dysfunction and therapeutic strategy targeting this will be reviewed.Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and | Samuel S.Shin C.Edward Dixon | 2015 | Neural Regeneration Research2015，10，10： | 3 |
| 2 | 延边牛PLIN2基因CDS区克隆、生物信息学分析及其表达规律研究显示文摘本研究旨在克隆延边牛脂肪分化相关蛋白PLIN2基因完整CDS区,通过生物信息学分析PLIN2基因CDS区序列和蛋白质基本特性,探讨其在延边牛不同组织及前体脂肪细胞成脂过程中的表达规律。选取18月龄去势的延边牛为研究对象,利用RT-PCR和基因克隆获得延边牛PLIN2基因,与其他物种进行同源性比对及系统进化树构建,利用生物信息学方法预测PLIN2编码蛋白质的理化性质、潜在磷酸化位点及糖基化位点、二硫键分析、信号肽、亚细胞定位、蛋白高级结构,利用实时荧光定量PCR检测PLIN2基因在延边牛不同组织中的表达水平。结果显示,延边牛PLIN2基因CDS长1353 bp,编码450个氨基酸;同源性比对发现延边牛PLIN2基因与黄牛、水牛、绵羊、山羊、野猪、人、小鼠和野鸡的同源性分别为100%、98.7%、96.7%、97.1%、85.5%、86.3%、47.3%和49.1%;系统进化树表明,延边牛与黄牛、水牛的亲缘关系最近,与野鸡的亲缘关系最远。PLIN2蛋白为不稳定蛋白,具有一定亲水性,存在61个潜在的磷酸化位点、16个O-糖基化潜在位点、12个N-糖基化潜在位点,存在2个二硫键,不存在信号肽,主要分布于细胞核中,细胞质和线粒体中有少量分布。PLIN2蛋白高级结构预测该蛋白是由α-螺旋、延伸链、无规则卷曲和β-转角组成,为混合型蛋白,通过无规则卷曲连接,以α-螺旋为主。实时荧光定量PCR结果显示,PLIN2基因在延边牛小肠组织中表达量最高,其次为背最长肌和肾脏组织。本研究结果可为进一步研究PLIN2基因的功能提供借鉴。 | 孙建富 崔岩 张军芳 王英 孙斌 李强 Seong H.Choi Jong S.Shin 李香子 | 2021 | 中国畜牧兽医2021，48，3： | 3 |
| 3 | Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements显示文摘Enlarged vestibular aqueduct(EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multidetector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. Seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients(ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements; ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss. | Misun Hwang Ryan Marovich Samuel S.Shin David Chi Barton F.Branstetter IV | 2015 | Journal of Otology2015，10，1： | 2 |
| 4 | Component analysis and sensory evaluation of Korean black raspberry (Rubus coreanus Mique) wines显示文摘 | Jae W.Lim Jong T.Jeong Chul S.Shin | 2012 | International Journal of Food Science & Technology2012，，5： | 1 |
| 5 | The influence of patient position on withdrawal force of thoracic epidural catheters*显示文摘 | W. S.Sim J. W.Choi C. J.Lee F. S.Nahm S. H.Lee B. S.Shin H. S.Cho | 2011 | Anaesthesia2011，，1： | 1 |
| 6 | Life cycle CO2 evaluation on reinforced concrete structures with high-strength concrete显示文摘 | Tae S C.Baek S.Shin | | 0，，： | 1 |
| 7 | Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration显示文摘Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting. | Christian B.Ricks Samuel S.Shin Christopher Becker Ramesh Grandhi | 2014 | Neural Regeneration Research2014，9，17： | 1 |
| 8 | Genetic selection of sox1GFP‐expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation显示文摘 | S.Chung B.‐S.Shin E.Hedlund J.Pruszak A.Ferree Un JungKang OleIsacson Kwang‐SooKim | 2006 | Journal of Neurochemistry2006，，5： | 1 |
| 9 | 用氯化钠释出细胞内的西索米星显示文摘引言大多数氨基糖苷类抗生素在细胞内生物合成之后均释放至培养液中。但其中有些抗生素,如小单孢菌所产生的庆大霉素、西索米星、Verdamicin等则大部分同细胞结合,只有部分进入培养液。当培养产生的抗生素大部分均留在胞内时,尽管菌株经过诱变改良,但因细胞的最大容积有限,故最后产物效价很低。然而,如果在发酵期间所形成的抗生素能够不断地从细胞释出,即可获得较高效价或产量。在此项试验中,作者将NaCl加至培养基中以提高西索米星效价。菌种与培养本研究使用艾袅小单孢菌(Micromonospora inyoensis)IFO13156。制备的种子与发酵培养基在灭菌前调pH至8.0。 | Chul S.Shin 廖福荣 | 1989 | 国外医药(抗生素分册)1989，10，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员