| 4 | Immunopathogenesis of idiopathic nephrotic syndrome显示文摘Idiopathic nephrotic syndrome(INS)describes a group of rare glomerular diseases characterized by massive proteinuria and hypoalbuminemia in the absence of glomerular inflammatory lesions or immunoglobulin deposits.INS includes two main entities based on kidney biopsy findings:minimal-change nephrotic syndrome(MCNS)and focal segmental glomerulosclerosis(FSGS).The treatment of INS relies on steroids and/or immunosuppressive drugs(calcineurin inhibitors,cyclophosphamide,mycophenolate mofetil,and rituximab). | B.Savas F.Fofana S.Le Gouvello A.Pawlak D.Sahali M.Ollero | 2022 | Cellular & Molecular Immunology2022，19，12： | 1 |
| 5 | Metamorphic gradient modification in the Early Cretaceous Northern Andes subduction zone:A record from thermally overprinted high-pressure rocks显示文摘New field observations and petrological data from Early Cretaceous metamorphic rocks in the Central Cordillera of the Colombian Andes allowed the recognition of thermally overprinted high-pressure rocks derived from oceanic crust protoliths.The obtained metamorphic path suggests that the rocks evolved from blueschist to eclogite facies towards upper amphibolite to high-pressure granulite facies transitional conditions.Eclogite facies conditions,better recorded in mafic protoliths,are revealed by relic lawsonite and phengite,bleb-to worm-like diopside-albite symplectites,as well as garnet core composition.Upper amphibolite to high pressure granulite facies overprinting is supported by coarse-grained brown-colored Ti-rich amphibole,augite,and oligoclase recrystallization,as well as the record of partial melting leucosomes.Phase equilibria and pressure-temperature(P-T)path modeling suggest initial high-pressure metamorphic conditions M1 yielding 18.2-24.5 kbar and 465-580℃,followed by upper amphibolite to high pressure granulite facies overprinting stage M2 yielding 6.5-14.2 kbar and 580-720℃.Retrograde conditions M3 obtained through chlorite thermometry yield temperatures ranging around 286-400℃at pressures below 6.5-11 kbar.The obtained clockwise P-T path,the garnet zonation pattern revealing a decrease in X_(grs)/X_(prp)related to Mg#increment from core to rim,the presence of partial melting veins,as well as regional constraints,document the modification of the thermal structure of the active subduction zone in Northern Andes during the Early Cretaceous.Such increment of the metamorphic gradient within the subduction interface is associated with slab roll-back geodynamics where hot mantle inflow was triggered.This scenario is also argued by the reported trench-ward magmatic arc migration and multiple extensional basin formation during this period.The presented example constitutes the first report of Cretaceous roll-back-related metamorphism in the Caribbean and Andean realms,representing an additional piece of evidence for a margin-scale extensional event that modified the northwestern border of South America during the Early Cretaceous. | D.S.Avellaneda-Jiménez A.Cardona V.Valencia S.León I.F.Blanco-Quintero | 2022 | Geoscience Frontiers2022，13，2： | 0 |
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