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| 1 | Notch signaling:Its essential roles in bone and craniofacial development显示文摘Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much more.More specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the skeleton.The craniofacial skeleton is complex and understanding its development has remained an important focus in biology.In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face develop.We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future. | Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo Jones Elam Coalson Junyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linjuan Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael J.Lee Jennifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes Jason Strelzow Mostafa El Dafrawy Russell R.Reid | 2021 | Genes & Diseases2021，8，1： | 4 |
| 2 | Glial cells in neuronal development:recent advances and insights from Drosophila melanogaster显示文摘Glia outnumber neurons and are the most abundant cell type in the nervous system.Whereas neurons are the major carriers, transducers, and processors of information, glial cells, once considered mainly to play a passive supporting role, are now recognized for their active contributions to almost every aspect of nervous system development.Recently, insights from the invertebrate organism Drosophila melanogaster have advanced our knowledge of glial cell biology.In particular, findings on neuron-glia interactions via intrinsic and extrinsic mechanisms have shed light on the importance of glia during different stages of neuronal development.Here, we summarize recent advances in understanding the functions of Drosophila glia, which resemble their mammalian counterparts in morphology and function, neural stem-cell conversion, synapse formation, and developmental axon pruning.These discoveries reinforce the idea that glia are substantial players in the developing nervous system and further advance the understanding of mechanisms leading to neurodegeneration. | Jiayao Ou Yijing He Xi Xiao Tian-Ming Yu Changyan Chen Zongbao Gao Margaret S.Ho | 2014 | Neuroscience Bulletin2014，30，4： | 3 |
| 3 | Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury显示文摘Injuries to the central nervous system(CNS)such as stroke,brain,and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon regeneration.The brain has a surprising intrinsic capability of recovering itself after injury.However,the hostile extrinsic microenvironment significantly hinders axon regeneration.Recent advances have indicated that the inactivation of intrinsic regenerative pathways plays a pivotal role in the failure of most adult CNS neuronal regeneration.Particularly,substantial evidence has convincingly demonstrated that the mechanistic target of rapamycin(mTOR)signaling is one of the most crucial intrinsic regenerative pathways that drive axonal regeneration and sprouting in various CNS injuries.In this review,we will discuss the recent findings and highlight the critical roles of mTOR pathway in axon regeneration in different types of CNS injury.Importantly,we will demonstrate that the reactivation of this regenerative pathway can be achieved by blocking the key mTOR signaling components such as phosphatase and tensin homolog(PTEN).Given that multiple mTOR signaling components are endogenous inhibitory factors of this pathway,we will discuss the promising potential of RNA-based therapeutics which are particularly suitable for this purpose,and the fact that they have attracted substantial attention recently after the success of coronavirus disease 2019 vaccination.To specifically tackle the blood-brain barrier issue,we will review the current technology to deliver these RNA therapeutics into the brain with a focus on nanoparticle technology.We will propose the clinical application of these RNA-mediated therapies in combination with the brain-targeted drug delivery approach against mTOR signaling components as an effective and feasible therapeutic strategy aiming to enhance axonal regeneration for functional recovery after CNS injury. | Ming-Xi Li Jing-Wen Weng Eric S.Ho Shing Fung Chow Chi Kwan Tsang | 2022 | Neural Regeneration Research2022，17，10： | 2 |
| 4 | Smoking and depressive symptoms in Chinese elderly in Hong Kong显示文摘 | T. H.Lam Z. B.Li S. Y.Ho W. M.Chan K. S.Ho M. P.Li G. M.Leung | 2004 | Acta Psychiatrica Scandinavica2004，，3： | 1 |
| 5 | Young age is not a poor prognostic marker in colorectal cancer显示文摘 | Y. F. A.Chung K.‐W.Eu D.Machin J. M. S.Ho D. C. N. K.Nyam A. F. P. K.Leong Y. H.Ho F.Seow‐Choen | 2003 | Br J Surg2003，，9： | 1 |
| 6 | Analysis of Glial Distribution in Drosophila Adult Brains显示文摘Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body(MB), ellipsoid body(EB),and antennal lobe(AL) in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL. | Jiayao Ou Zongbao Gao Li Song Margaret S.Ho | 2016 | Neuroscience Bulletin2016，32，2： | 1 |
| 7 | A Shared Neural Node for Multiple Innate Behaviors in Drosophila显示文摘The nervous system orchestrates diverse behaviors such as reproduction, sleep, feeding, and aggression, and selects a single behavior for execution at any given time. This requires neural mechanisms for behavioral selection sensitive to both internal physiological states and external environmental conditions. For example, hungry | Margaret S.Ho | 2018 | Neuroscience Bulletin2018，34，6： | 1 |
| 8 | Young age is not a poor prognostic marker in colorectal cancer显示文摘 | Y. F. A.Chung K.‐W.Eu D.Machin J. M. S.Ho D. C. N. K.Nyam A. F. P. K.Leong Y. H.Ho F.Seow‐Choen | 2003 | Br J Surg2003，，9： | 1 |
| 9 | Neurodevelopment and degeneration显示文摘Over the past decades,continuous effort has been made to resolve unsettled matters in the emerging scene of neuronal development.Despite the rapid progress,neuroscientists remain fascinated by the intricate networks of signaling pathways and molecules conserved | Margaret S.Ho | 2014 | Neuroscience Bulletin2014，30，4： | 0 |
| 10 | The noncanonical role of the protease cathepsin D as a cofilin phosphatase显示文摘Cathepsin D(cathD)is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments.Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling.In neutral pH environments,the cathD precursor directly dephosphorylates and activates the actin-severing protein cofilin independent of its proteolytic activity,whereas mature cathD degrades cofilin in acidic pH conditions.During development,cathD complements the canonical cofilin phosphatase slingshot and regulates the morphogenesis of actin-based structures.Moreover,suppression of cathD phosphatase activity leads to defective actin organization and cytokinesis failure.Our findings identify cathD as a dual-function molecule,whose functional switch is regulated by environmental pH and its maturation state,and reveal a novel regulatory role of cathD in actin-based cellular processes. | Yi-Jun Liu Ting Zhang Sicong Chen Daxiao Cheng Cunjin Wu Xingyue Wang Duo Duan Liya Zhu Huifang Lou Zhefeng Gong Xiao-Dong Wang Margaret S.Ho Shumin Duan | 2021 | Cell Research2021，31，7： | 0 |
| 11 | 新时代的健康传播研究:来自科学传播的启示显示文摘一、环境与技术:回望当下的健康传播研究新冠肺炎疫情与新兴的信息传播技术为健康传播带来了诸多机遇与挑战,同时塑造了当前的健康传播研究。我们必须承认,新冠肺炎疫情带来了前所未有的公共卫生危机,至今威胁着人类的健康与福祉。但另一方面,这个特殊的语境的确为健康传播研究创造了契机。 | Shirley S.Ho 陈梁(翻译) | 2022 | 全球传媒学刊2022，9，3： | 0 |
| 12 | The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease显示文摘Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy bodies.Dysfunction in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s disease.However,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the brain.In the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult brain.Results from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in glia.Atg9 is persistently in contact with these organelles.Lacking glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate degradation.This suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic degradation.Importantly,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial activation.Our findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s disease.These results may provide new insights on the underlying mechanism of Parkinson’s disease. | Shuanglong Yi Linfang Wang Margaret S.Ho Shiping Zhang | 2024 | Neural Regeneration Research2024，19，5： | 0 |
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