| 2 | Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets显示文摘Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response analysis.Nanovectors of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility properties.In addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic approaches.Post-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are highlighted.SPION parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are discussed.We also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of toxins.Finally,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is reviewed.In summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics. | Divya S.Parimi Yamini Gupta Sreekar Marpu Chandra S.Bhatt Tharun K.Bollu Anil K.Suresh | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 3 | 2000~2015年非洲疟疾防治措施对恶性疟原虫的影响显示文摘自2000年以来,在撒哈拉以南非洲地区的抗疟行动干预覆盖率达到前所未有的水平,了解其控制效果对指导下一步控制措施的制定至关重要。然而由于监测方法较为简单和缺乏可靠的监测数据,非洲不同流行模式下疟疾干预措施对疾病发病水平的影响仍然知之甚少。本研究根据疟疾现场调查的大量数据,重建从2000年至2015年的干预措施覆盖率变化趋势,并量化疟疾防控工作对其影响。研究结果显示从2000年至2015年,非洲恶性疟原虫带虫率减半,发病率下降了40%,自2000年以来干预措施已经避免了6.63(5.42—7.53可信区间)亿的临床病例。经杀虫剂处理过的蚊帐作为最广泛的干预措施,为降低疾病发病做出最大的贡献率(避免了68%的发病)。尽管干预措施的效果仍然低于预期水平,目前的疟疾干预措施已明显降低了整个非洲大陆的疟疾发病率。2015年之后的控制策略应以继续加强目前的干预措施,并保持杀虫剂有效性为基础。 | S.Bhatt E.Cameron 邓舒 刘永孝 | 2016 | 安徽预防医学杂志2016，0，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员