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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Quantitying the bullwhip effect in a supply chain: The impact of forecasting ,lead times and information显示文摘 | Chen F Drezner Z Ryan J K | 2000 | Management Science2000，46，3： | 1 |
| 5 | The nature and distribution of Messinian erosional surface-Indicators of a several-kilometerdeep Mediterranean in Miocene显示文摘 | Ryan W B F Cita M B | 1978 | Marine Geology1978，27，34： | 1 |
| 6 | Review of the tectonics of the Levant Rift system:the structural significance of oblique continental breakup显示文摘 | Mart Y Ryan W B F Lunina O V | 2005 | Tectonophysics2005，395，： | 1 |
| 7 | PAPNET-direeted resereening of cervicovaginal smears:a study of 101 cases of atypical squamous cells of undetermined significauce显示文摘 | Ryan M R Stastny J F Remmers R | 1996 | Am J Clin Pathol1996，105，6： | 1 |
| 8 | Effect of yucca schidigera and its mechanism of action in reducing ammonia leverls in a biologically filtered environment显示文摘 | Ryan J P Leek B F | 1993 | J Anim Sci1993，71，1： | 1 |
| 9 | The impact of exponential smoothing forecasts on the bullwhip effect显示文摘 | Chen F Ryan J Simchi-Levi D | 2000 | Naval Research Logistics2000，47，4： | 1 |
| 10 | Ketamine mouthwash for mucositis pain 显示文摘 | Ryan A J Lin F Atayee RS | 2009 | J Palliat Med2009，12，11： | 1 |
| 11 | Quantifying the bullwhip effect in a simple supply chain:the impact of forecasting,lead times,and information显示文摘 | CHEN F DREZNER Z RYAN J K | 2000 | Management Science2000，46，3： | 1 |
| 12 | Surface crosslinking of polyethylene and adhesive joint strength显示文摘 | SCHONHORN H RYAN F W | 1974 | Appl Polym Sci1974，18，1： | 1 |
| 13 | Quantifying the bullwhip effect in a simple supply chain: the impact of forecasting,lead times, and information显示文摘 | Chen F Drezner Z Ryan J K | 2000 | Management Science2000，46，3： | 1 |
| 14 | On the global variation of precipitating layer clouds显示文摘 | Ryan B F | 1996 | Bull Amer Meteor Soc1996，77，1： | 1 |
| 15 | Electron beam lithography-resolution limits显示文摘 | Broers A N Hoole A C F Ryan J M | 1996 | Microelectronic Engineering1996，32，： | 1 |
| 16 | Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells 显示文摘 | Ryan C J Zavodovskaya M Youngren J F | 2008 | Prostate2008，68，11： | 1 |
| 17 | Oligosaccharide signals in plants: A current assessment 显示文摘 | Ryan C A Farmer E F | 1991 | Annu Rev Phy-Siol Mol Biol1991，42，651： | 1 |
| 18 | The Siberian Lithosphere Traverse: Mantle Terranes and the Assembly of the Siberian Craton显示文摘 | GRIFFIN W L RYAN C G KAMINSKY F V | 1999 | Tectono- physics1999，310，1234： | 1 |
| 19 | Evaluating MBA- Program Admissions Criteria: The Relationship Between Pre-MBA Work Experience and Post-MBA Career Outcomes显示文摘 | George F Dreher and Katherine C Ryan | 2003 | Research in Higher Education2003，，06： | 1 |
| 20 | An information-theoretic primer on complexity, self-organization, and emergence 显示文摘 | Prokopenko M Boschetti F Ryan A | 2009 | Complexity2009，15，1： | 1 |
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