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| 1 | Subtle trap recognition based on seismic sedimentology- A case study from Shengli Oilfield显示文摘地震沉积科学用地震数据是沉积岩石和外形的学习。然而,经常,沉积身体特征不能被描述份量上由于地震分辨率的限制。高决定倒置抵消这限制并且被用于地震沉积科学在复杂地质的条件下面识别微妙的陷井,从而拓宽地震沉积科学的适用的范围。在这篇论文,基于地震沉积科学,地震控制阶段的非线性的随机的倒置被用来在 Shengli 油矿在 Chezhen 消沉预言 Es3 的沙的集团企业水库。厚度和在几个阶段的沙的集团企业身体的沉积微外形地图被钻介绍,几个微妙的陷井被预言并且验证。 | Huang Handong Zhang Ruwei Luo Qun Zhao Di Peng Yongmin | 2009 | Applied Geophysics2009，6，2： | 10 |
| 2 | A preliminary analysis of fishery resource exhaustion in the context of biodiversity decline显示文摘Marine biodiversity in almost all oceans is being threatened at the genetic, species, and ecosystem levels. The marine ecosystem is being degraded and the extinction rate of marine organisms has accelerated. In this paper, the potential causes of fishery resource exhaustion in the East China Sea are analyzed, including the change in the stoichiometric composition of seawater with regard to the concentrations of N and P, toxic effects of marine pollution, marine habitat destruction, increased seawater temperatures caused by climate warming, ocean acidification, pressure from overfishing, and the spread of marine pathogenic bacteria. It is believed that the factors mentioned above have significant impact on the exhaustion of fishery resources in the East China Sea. However, considering the cumulative, synergistic, and superimposed effects as well as the amplification effects resulting from their interactions, the actual risk of ecological extinction of marine organisms might be even more severe than that previously estimated. Hence, ecosystem management and research focused on a single risk factor or influencing factor is not enough to prevent marine ecosystem degradation and fishery resource exhaustion. A comprehensive, systematic, effective, and ecosystem-based management policy is imperative for healthy and sustainable fishery development in the East China Sea. | ZHAO ShuJiang Lü BaoQiang LI RuWei ZHU AiYi WU ChangWen | 2016 | Science China Earth Sciences2016，59，2： | 6 |
| 3 | Nanosecond-pulsed, dual-wavelength, passively Q-switched ytterbium-doped bulk laser based on few-layer MoS2 saturable absorber显示文摘A compact saturable absorber mirror(SAM) based on few-layer molybdenum disulfide(MoS2) nanoplatelets was fabricated and successfully used as an efficient saturable absorber(SA) for the passively Q-switched solid-state laser at 1 μm wavelength. Pulses as short as 182 ns were obtained from a ytterbium-doped(Yb:LGGG) bulk laser Q-switched by the MoS2 SAM, which we believe to be the shortest one ever achieved from the MoS2 SAs-based Q-switched bulk lasers. A maximum average output power of 0.6 W was obtained with a slope efficiency of 24%,corresponding to single pulse energy up to 1.8 μJ. In addition, the simultaneous dual-wavelength Q-switching at 1025.2 and 1028.1 nm has been successfully achieved. The results indicate the promising potential of few-layer MoS2 nanoplatelets as nonlinear optical switches for achieving efficient pulsed bulk lasers. | Fei Lou Ruwei Zhao Jingliang He Zhitai Jia Xiancui Su Zhaowei Wang Jia Hou Baitao Zhang | 2015 | Photonics Research2015，3，2： | 5 |
| 4 | Diurnal drooling in Chinese patients with Parkinson’s disease显示文摘 | Ruwei Ou Xiaoyan Guo Qianqian Wei Bei Cao Jing Yang Wei Song Ke Chen Bi Zhao Xueping Chen Huifang Shang | 2015 | Journal of the Neurological Sciences . 2015 (1-2)2015，，1： | 1 |
| 5 | Prevalence and clinical correlates of drooling in Parkinson disease: A study on 518 Chinese patients显示文摘 | Ruwei Ou Xiaoyan Guo Qianqian Wei Bei Cao Jing Yang Wei Song Na Shao Bi Zhao Xueping Chen Huifang Shang | 2014 | Parkinsonism and Related Disorders2014，，： | 1 |
| 6 | Rare variant analysis of PLXNA1 in Parkinson’s disease in the Chinese population显示文摘Recently,p.Glu1121Ter in PLXNA1 was identified as po-tential cause for a patient with parkinsonism.However,no further replication has been conducted in a wider range of Parkinson’s disease(PD)cohorts.To evaluate the genetic association of PLXNA1 with PD,we systematically analyzed the rare protein-coding variants in 1,245 Chinese patients with whole exome sequencing. | Chunyu Li Ruwei Ou Yanbing Hou Junyu Lin Kuncheng Liu Qianqian Wei Xueping Chen Wei Song Bi Zhao Huifang Shang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 7 | The efficacies and biomarker investigations of antiprogrammed death-1 (anti-PD-1)-based therapies for metastatic bone and soft tissue sarcoma显示文摘Objective:Sarcomas are a group of rare malignancies with various subtypes.Patients with metastatic sarcoma who have failed traditional treatments can possibly achieve better prognoses from using novel therapies,including anti-programmed death-1(PD-1)-based therapies.Methods:We retrospectively analyzed clinical data of 24 metastatic sarcoma patients from June 15,2016 to December 30,2019.These patients mainly received angiogenesis inhibitors combined with anti-PD-1 therapy after they became resistant to traditional treatments.Furthermore,8 patients underwent panel DNA and whole transcript sequencing.Results:Six patients received 2 cycles of anti-PD-1 therapy and were included in the safety evaluation only group.The median follow-up time was 5.77 months.The median progression-free survival was 7.59 months,the overall response rate was 16.7%and the disease control rate was 55.6%.Based on whole exome and transcript sequencing data,there was no association between TMB,TNB,MSI,HLA-LOH,and PD-L1 expressions and sarcoma types with clinical responses.Immunotherapy efficacy and bioinformatics analyses indicated higher intratumoral heterogeneity(ITH)in progressive disease(PD)patients and lower ITH in partial response(PR)and stable disease patients.A higher percentage of immune cell infiltration,especially monocytes,was observed in PR patients.Active stromal gene expression was increased in PD patients but decreased in PR patients.Enrichment analysis revealed that an increased TGF-βsignaling pathway was reversely correlated with anti-PD-1 efficacy,while a decreased inflammatory response signaling pathway was positively correlated with anti-PD-1 efficacy.Conclusions:Our study showed PD-1 inhibitors combined with anti-angiogenesis agents were effective and well-tolerated.ITH,monocyte ratio,stroma subtypes,and the status of immune-associated signaling pathways may be related with anti-PD-1 based therapy. | Jia Lu Ting Li Zhichao Liao Hui Yu Yongtian Zhao Haixiao Wu Zhiwu Ren Jun Zhao Ruwei Xing Sheng Teng Yun Yang Xiangchun Li Kexin Chen Jonathan Trent Jilong Yang | 2022 | Cancer Biology & Medicine2022，19，6： | 0 |
| 8 | Clinical study of apatinib in the treatment of stage IV osteogenic sarcoma after failure of chemotherapy显示文摘Objective:To analyze the efficacy and safety o f apatinib in the treatment of stage IV osteogenic sarcoma after chemotherapy failure through a single-arm,prospective,and open clinical phase II study.Methods:Information on 34 patients with stage IV osteogenic sarcoma treated with apatinib after failure o f chemotherapy in Tianjin Medical University Cancer Institute and Hospital between September 2015 and December 2019 was collected and analyzed.The participants included 23 males and 11 females,with an average age of 35.24 years(11-73 years).The objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS),PFS rate(PFR),and overall survival(OS)were evaluated.The treatmentrelated adverse events(AEs)and safety of apatinib were also evaluated.Results:O f the 34 patients,33 were able to be evaluated for efficacy.One patient received apatinib treatment for less than one cycle;therefore,only safety analysis was performed.The 12-week clinical evaluation showed that 2 patients had a partial response(PR),24 patients had stable disease(SD),and 7 patients had progressive disease(PD).The ORR,DCR,and PFR at 12 weeks were 6.06%(2/33),78.79%(26/33),and 82%,respectively.By the end of the follow-up,6 patients had SD(18.18%,6/33),27 patients had PD(81.82%,27/33),and 15 patients died because of disease progression(45.45%,15/33).The ORR was 0(0/33),the DCR was 18.18%(6/33),and the median PFS(mPFS)was 7.89 months(95%Cl:4.56-11.21).The median OS(mOS)was 17.61 months(95%Cl:10.85-24.37).The most common treatment-related AEs were hand-foot syndrome(35.29%,12/34),proteinuria(32.35%,11/34),and hypertension(32.35%,11/34). | Zhichao Liao Ting Li Chao Zhang Xinyue Liu Ruwei Xing Sheng Teng Yun Yang Gang Zhao Xu Bai Jun Zhao Jilong Yang | 2020 | Cancer Biology & Medicine2020，17，2： | 0 |
| 9 | Generation of 100 nJ pulse,1 W average power at 2μm from an intermode beating mode-locked all-fiber laser显示文摘We report on the investigation of intermode beating mode-locked(IBML)pulse generation in a simple all-fiber Tm^3+-doped double clad fiber laser(TDFL).This IBML TDFL is implemented by matching longitudinal-mode frequency between 793 nm laser and TDFL without extra mode locker.The central wavelength of 1983 nm,the fundamental pulse frequency of 9.6 MHz and the signal-to-noise ratio(SNR)of>50 dB are achieved in this IBML TDFL.With laser cavity optimization,the IBML TDFL can finally generate an average output power of 1.03 W with corresponding pulse energy of 107 nJ.These results can provide an easily accessible way to develop compact large-energy,highpower TDFLs. | Jiaji Zhang Duanduan Wu Ruwei Zhao Rongping Wang Shixun Dai | 2019 | High Power Laser Science and Engineering2019，7，4： | 0 |
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