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| 1 | Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity显示文摘Mesalazine is a 5-aminosalicylic acid derivative that has been widely used to treat patients with inflammatory bowel disease. Accumulating evidence indicates that mesalazine has a very low rate of adverse drug reactions and is well tolerated by patients. However, a few cases of pulmonary and cardiac disease related to mesalazine have been reported in the past, though infrequently, preventing clinicians from diagnosing the conditions early. We describe the case of a 32-yearold man with ulcerative colitis who was admitted with a two-month history of persistent fever following mesalazine treatment initiated 14 mo earlier. At the time of admission, mesalazine dose was increased from 1.5 to 3.0 g/d, and antibiotic therapy was started with no improvement. Three weeks after admission, the patient developed dyspnea, non-productive cough, and chest pain. Severe eosinophilia was detected in laboratory tests, and a computed tomography scan revealed interstitial infiltrates in both lungs, as well as a large pericardial effusion. The bronchoalveolar lavage reported a CD4/CD8 ratio of 0.5, and an increased eosinophil count. Transbronchial biopsy examination showed a severe eosinophilic infiltrate of the lung tissue. Mesalazine-induced cardiopulmonary hypersensitivity was suspected after excluding other possible etiologies. Consequently, mesalazine treatment was suspended, and corticosteroid therapy was initiated, resulting in resolution of symptoms and radiologic abnormalities. We conclude that mesalazine-induced pulmonary and cardiac hypersensitivity should always be considered in the differential diagnosis of unexplained cardiopulmonary symptoms and radiographic abnormalities in patients with inflammatory bowel disease. | José Ferrusquía Isabel Pérez-Martínez Ricardo Gómez de la Torre María Luisa Fernández-Almira Ruth de Francisco Luis Rodrigo Sabino Riestra | 2015 | World Journal of Gastroenterology2015，21，13： | 5 |
| 2 | Re-challenge chemotherapy with gemcitabine plus carboplatin in patients with non-small cell lung cancer显示文摘Despite recent improvements to current therapies and the emergence of novel agents to manage advanced non-small cell lung cancer(NSCLC),the patients′overall survival remains poor.Re-challenging with first-line chemotherapy upon relapse is common in the management of small cell lung cancer but is not well reported for advanced NSCLC.NSCLC relapse has been attributed to acquired drug resistance,but the repopulation of sensitive clones may also play a role,in which case re-challenge may be appropriate.Here,we report the results of re-challenge with gemcitabine plus carboplatin in 22 patients from a single institution who had previously received gemcitabine plus platinum in the first-line setting and had either partial response or a progression-free interval of longer than 6 months.In this retrospective study,the charts of patients who underwent second-line chemotherapy for NSCLC in our cancer center between January 2005 and April 2010 were reviewed.All the patients who received a combination of gemcitabine and carboplatin for re-challenge were included in the study.These patients were offered second-line treatment on confirmation of clear radiological disease progression.The overall response rate was 15%and disease control rate was 75%.The median survival time was 10.4 months,with 46%of patients alive at 1 year.These results suggest that re-challenge chemotherapy should be considered in selected patients with radiological partial response or a progression-free survival of longer than 6 months to the initial therapy. | Khurum Khan Gerard G Hanna Lynn Campbell Paula Scullin Adnan Hussain Ruth L Eakin Jonathan McAleese | 2013 | Chinese Journal of Cancer2013，32，10： | 3 |
| 3 | Diagnosis of renal vascular disease with MR angiography显示文摘 | QIAN D O N G STEFAN O S Ruth C C | 1999 | Radiographics1999，19，6： | 2 |
| 4 | Tandem DNA recognition by PhoB, a two - component signal transduction transcriptional activator显示文摘 | BLANCO A G SOLA M GOMIS - RUTH F X | 2002 | Structure (Camb)2002，10，5： | 1 |
| 5 | Global consequences of land use显示文摘 | FOLEY J A RUTH D ASNER G F | 2005 | Science2005，309，5734： | 1 |
| 6 | Role of su- peroxide dismutases (SODs) in controlling oxidative stress in plants 显示文摘 | RUTH G A NEVAL E LENWOOD S H | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 7 | Gas chromatograpby-olfactometry (GC-O) and proton transfer reaction-mass spectrometry (PTR-MS) analysis of the flavor profile of Grana Padano,Parmigiano Reggiano,and Grana Trentino cheeses显示文摘 | BOSCAINI E VAN RUTH S BIASIOLI G | 2003 | J Asric Food Chem2003，，51： | 1 |
| 8 | Lack of independent prognostic significance of p21 and p27 expression in advanced ovarian cancer:an immunohistochemical study显示文摘 | Mark Baekelandt Ruth Holm Claes G | 1999 | Clinical Cancer Research1999，5，10： | 1 |
| 9 | Role of laparoscopic treatment of endometriosis :in patients with failed in vitro fertilization cycles显示文摘 | Eva L Linda G Ruth L | 2005 | Fertil Steril2005，84，6： | 1 |
| 10 | Thermosensitive poly(allylamine)-g- poly(N-isopropylacrylamide) : Synthesis, phase separation and particle formation显示文摘 | Ruths J Essler F Decher G | 2000 | Langmuir2000，16，： | 1 |
| 11 | Glucose-dependent modulation of insulin secretion and intracellular calciumol·L^-1 ions by GKA50, a glucokinase activator 显示文摘 | DANNIEL J RUTH S DEBRA G | 2007 | Diabetes2007，56，6： | 1 |
| 12 | Original article results and analysis of the 2008- 2009 Insulin In-jection Technique Question- naire survey显示文摘 | Carina DE Anders F Ruth G | 2010 | Journal of Diabetes2010，2，3： | 1 |
| 13 | Effects of qua- ternary-ammonium-based formulations on bacterial community dynamics and antimicrobial susceptibility 显示文摘 | ANDREW J M RUTH G L LOUISE E M | 2004 | Appl Environ Mi- crobiol2004，70，6： | 1 |
| 14 | Effect of slow release IL-I2 and IL-10 on inflammation, local macrophage function and reginal lymphoid response during mycobacterial (Thl) and schistosmal (Th2) antigan-elieted pulmonary granuloma formation显示文摘 | RUTH J H DI STEFANO A TURATO G | 2003 | Inflamm Res2003，460，： | 1 |
| 15 | Polymer/layered silicate nanocomposites as high performance ablative materials显示文摘 | Vaia R A Price G Ruth P N | 1999 | Apply Clay Science1999，15，： | 1 |
| 16 | Nitrogen leaching from conventional versus organic farming systems-a systems modelling approach显示文摘 | Birgitte H Erik S K Ruth G | 2000 | European Journal of Agronomy2000，13，： | 1 |
| 17 | Polymer/layered silicate nanocomposites as high performance ablative materials显示文摘 | Vaia R A Price G Ruth P N | 1999 | Appl Clay Sci1999，15，1： | 1 |
| 18 | Membrane durability in PEM fuel cells显示文摘 | Liu W Ruth K Rusch G | | 0，，： | 1 |
| 19 | Constraint to adaptive evolution in response to global warming显示文摘 | ETTERSON J R RUTH G S | 2001 | Science2001，10，5540： | 1 |
| 20 | Acyclovir in the treatment of Ramsay Hunt syndrome 显示文摘 | Nechama U Elhanan G Ruth K C Ilana D | 2003 | Otolaryngology - Head and Neck Surgery2003，129，4： | 1 |
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