2篇
您的检索式：作者名="Ruslan G.Tuguntaev"
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| 1 | Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques显示文摘Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular event.Early detection and precise intervention of VASP hold great clinical significance,yet remain a major challenge.Photodynamic therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser irradiation.In this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR imaging.The NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid artery.Under the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within VASPs.In response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy macrophages.After therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly reduced.Furthermore,the formulated NPs displayed excellent biocompatibility.In conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis. | Mengqi Xu Cong Mao Haoting Chen Lu Liu Yabin Wang Abid Hussain Sulei Li Xu Zhang Ruslan G.Tuguntaev Xing-Jie Liang Weisheng Guo Feng Cao | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 2 | Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy显示文摘Rheumatoid arthritis(RA)is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane.Current therapeutic strategies for RA mainly aim to hamper the macrophages’proliferation and reduce the production of pro-inflammatory cytokines.Therefore,the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy.Nowadays,the nanocarrier system incorporated with stimuli-responsive property is being intensively studied,showing the potentially tremendous value of specific therapy.Stimuli-responsive(i.e.,pH,temperature,light,redox,and enzyme)polymeric nanomaterials,as an important component of nanoparticulate carriers,have been intensively developed for various diseases treatment.A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents(nanotherapeutics)in the treatment of inflammatory arthritis remains largely unexplored.The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations.Herein,we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA.The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine. | Yingsi Xie Ruslan G.Tuguntaev Cong Mao Haoting Chen Ying Tao Shixiang Wang Bin Yang Weisheng Guo | 2020 | Biophysics Reports2020，6，5： | 0 |
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