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| 1 | Gut microbiome,liver immunology,and liver diseases显示文摘The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology.The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circulating nutrients and endotoxins derived from the gut microbiota.The delicate interaction between the gut and liver prevents accidental immune activation against otherwise harmless antigens.Work on the interplay between the gut microbiota and liver has assisted in understanding the pathophysiology of various liver diseases.Of immense importance is the step from high-throughput sequencing(correlation)to mechanistic studies(causality)and therapeutic intervention.Here,we review the gut microbiota,liver immunology,and the interaction between the gut and liver.In addition,the impairment in the gut-liver axis found in various liver diseases is reviewed here,with an emphasis on alcohol-associated liver disease(ALD),nonalcoholic fatty liver disease(NAFLD),and autoimmune liver disease(AILD).On the basis of growing evidence from these preclinical studies,we propose that the gut-liver axis paves the way for targeted therapeutic modalities for liver diseases. | Rui Wang Ruqi Tang Bo Li Xiong Ma Bernd Schnabl Herbert Tilg | 2021 | Cellular & Molecular Immunology2021，18，1： | 23 |
| 2 | The microbiome and autoimmunity: a paradigm from the gut–liver axis显示文摘Microbial cells significantly outnumber human cells in the body,and the microbial flora at mucosal sites are shaped by environmental factors and,less intuitively,act on host immune responses,as demonstrated by experimental data in germ-free and gnotobiotic studies.Our understanding of this link stems from the established connection between infectious bacteria and immune tolerance breakdown,as observed in rheumatic fever triggered by Streptococci via molecular mimicry,epitope spread and bystander effects.The availability of high-throughput techniques has significantly advanced our capacity to sequence the microbiome and demonstrated variable degrees of dysbiosis in numerous autoimmune diseases,including rheumatoid arthritis,type 1 diabetes,multiple sclerosis and autoimmune liver disease.It remains unknown whether the observed differences are related to the disease pathogenesis or follow the therapeutic and inflammatory changes and are thus mere epiphenomena.In fact,there are only limited data on the molecular mechanisms linking the microbiota to autoimmunity,and microbial therapeutics is being investigated to prevent or halt autoimmune diseases.As a putative mechanism,it is of particular interest that the apoptosis of intestinal epithelial cells in response to microbial stimuli enables the presentation of self-antigens,giving rise to the differentiation of autoreactive Th17 cells and other T helper cells.This comprehensive review will illustrate the data demonstrating the crosstalk between intestinal microbiome and host innate and adaptive immunity,with an emphasis on how dysbiosis may influence systemic autoimmunity.In particular,a gut–liver axis involving the intestinal microbiome and hepatic autoimmunity is elucidated as a paradigm,considering its anatomic and physiological connections. | Bo Li Carlo Selmi Ruqi Tang ME Gershwin Xiong Ma | 2018 | Cellular & Molecular Immunology2018，15，6： | 15 |
| 3 | Two-axis model development of cage-rotor brushless doubly-fed machines 显示文摘 | LI Ruqi WALLACE A SPEE R | 1991 | IEEE Trans on Energy Conversion1991，6，3： | 1 |
| 4 | Geology and timing of mineralization at the Cangshang gold deposit, north-western Jiaodong Peninsula, China显示文摘 | Xiao’ou Zhang Peter A. Cawood Simon A. Wilde Ruqi Liu Hailin Song Wen Li Lawrence W. Snee | 2003 | Mineralium Deposita2003，，2： | 1 |
| 5 | Two-axis model development of cage-rotor brushless doubly-fed machines显示文摘 | LI Ruqi WALLACE A SPEE R | 1991 | IEEE Trans on Energy Conversion1991，6，3： | 1 |
| 6 | Synchronous drive performance of brushless doubly-fed motors显示文摘 | Li Ruqi Spee R Wallace A K | 1994 | IEEE Transactions on Industry Applications1994，30，4： | 1 |
| 7 | Tow-axis model development of cage-rotorbrushless doubly-fed motors显示文摘 | Li Ruqi Walla('e A | 1991 | IEEE Transon En- ergyConversion(S0885-8969)1991，6，3： | 1 |
| 8 | Two-axis model development of cage-rotor brushless doubly-fed machines显示文摘 | Ruqi Li Alan Wallace | 1991 | IEEE Transaetions on Energy Conversion1991，6，3： | 1 |
| 9 | Tow-axis Model Development of Cage-rotorBrushless Doubly-fed Motors 显示文摘 | Li Ruqi Wallace A | 1991 | IEEE Trans on Energy Conver- sion (S0885 -8969)1991，6，3： | 1 |
| 10 | Two-axis model development of cage - rotor brushless doubly-fed motors 显示文摘 | LI Ruqi WALLACE Alan SPEE Rene | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 11 | Determination of Converter Control Algorithm for Brush-less Doubly-Fed Induction Motor Drives Using Floquet Lyapunov Techniques显示文摘 | Ruqi Li | 1995 | IEEE Transactions on Power Electronics1995，10，1： | 1 |
| 12 | Two-axis Model Development of Cage-rotor Brushless Doubly-fed Machines显示文摘 | LI RUQI ALAN WALLACE SP**E R | 1991 | IEEE Trans Energy Conversion1991，6，3： | 1 |
| 13 | Dynamic simulation of brushless doubly-fed machines显示文摘 | Ruqi Li AlanWallace René Spée | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 14 | Two-axismodel development of cage-rotor brushless doubly-fed machines显示文摘 | Ruqi Li Alan Wallace Rene Spee | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 15 | Tow-axis model development of cage-rotor brushless doubly-fed motors显示文摘 | Li Ruqi Wallace A | 1991 | IEEE Trans on Energy Conversion (S0885-8969)1991，6，3： | 1 |
| 16 | Dynamic simulation of brushless doubly-fed machines 显示文摘 | Ruqi Li Alan Wallace Rene Spee | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 17 | Two-axis model development of cagerotor brushless doubly - fed machine显示文摘 | Ruqi Li Wallace A Spee R | 1991 | IEEE Trans on EC1991，6，3： | 1 |
| 18 | Two-axis model de- velopment of cage-rotor brushless double-fed machines 显示文摘 | LI Ruqi WALLACE Alan SPEE Rene | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 19 | Determination of convert- er control algorithms for brushless doubly-fed induction motor drives using Floquet and Lyapunov techniques 显示文摘 | LI Ruqi WALLACE Alan SPEE Rene | 1995 | IEEE Trans- actions on Power Electronics1995，10，1： | 1 |
| 20 | Tow-axis model development of cage-rotor brushless doubly-fed motors 显示文摘 | Li Ruqi Wallace A | 1991 | IEEE Trans on Energy Conversion1991，6，3： | 1 |
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