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| 1 | Powder metallurgy with space holder for porous titanium implants:A review显示文摘One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical properties.This stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis fixation.However,it can be inhibited by adapting the stiffness of the implant material.Since the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this work.As powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and manufacture.The most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography reported.Furthermore,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are discussed.Finally,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented. | Alejandra Rodriguez-Contreras Miquel Punset JoséA.Calero Francisco Javier Gil Elisa Ruperez JoséMaría Manero | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 2 | Molecular mechanisms of angiotensin II-induced vascular injury 显示文摘 | Ruiz-Ortega M Ruperez M Esteban V | 2003 | Curr Hypertens Rep2003，5，1： | 1 |
| 3 | Inflammation and angiotensin Ⅱ显示文摘 | Suzuki Y Ruiz-Ortega M Lorenzo O Ruperez M Esteban V Egido J | 2003 | Int J Biochem Cell Biol2003，35，： | 1 |
| 4 | Angiotensin Ⅱ increases connective tissue growth factor in the kidney显示文摘 | Ruperez M Ruiz-Ortega M Esteban V | | 0，，： | 1 |
| 5 | Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis显示文摘 | Ruperez M Lorenzo O Blanco-Colio LM | 2003 | Circulation2003，108，12： | 1 |
| 6 | Angiotensin II : a key factor in the inflammatory and fibrotic response in kidney diseases 显示文摘 | Marta Ruiz-Ortega Monica Ruperez Vanesa Esteban | | Nephrol Dial Transplant0，21，： | 1 |
| 7 | Angiotensin Ⅱ regulates the synthesis of proinflammatory cytokines and chemokines in the kidney 显示文摘 | Ruiz-Ortega M Ruperez M Lorenzo O | 2002 | Kidney Int Suppl2002，82，： | 1 |
| 8 | Metabolomics reveals metabolite changes in acute pulmonary embolism显示文摘 | Bujak R Garcia-Alvarez A Ruperez FJ | 2014 | J Proteome Res2014，13，2： | 1 |
| 9 | Isotope ratio mass spectrometry coupled to liquid and gas chromatography for wine ethanol characterization显示文摘 | CABAHERO A I RECIO J L RUPEREZ M | 2008 | Rapid Communications in MassSpectrometry2008，22，20： | 1 |
| 10 | The effects of okara on rat growth, cecal fermentation, and serum lipids显示文摘 | PRETAMO G RUPEREZ P ESPINOSA-MARTOS I | 2007 | European Food Research and Technology2007，，225： | 1 |
| 11 | Freezing rates and frozen storage effects on colour and sensory characteristics of pine apple fruits lices 显示文摘 | Bartocome A P Ruperez P Fuster C | 1996 | Journal of Food Science1996，61，1： | 1 |
| 12 | Angiotensin Ⅱ activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice显示文摘 | Lorenzo O Ruperez M | 2001 | Nephrol Dial Transplant2001，16，1： | 1 |
| 13 | Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney 显示文摘 | Ruiz - Ortega M Ruperez M Lorenzo O | 2002 | Kidney Int Suppl2002，，82： | 1 |
| 14 | Angiotensin Ⅱ increases connective tissue growth factor in the kidney显示文摘 | Ruperez M Ruiz-Ortega M Esteban V | 2003 | Am J Pathol2003，163，5： | 1 |
| 15 | Renal and vascular hyper2 Tension induced inflammation: role of angiotensin l显示文摘 | Ruiz2Ortega M Esteban V Ruperez M | 2006 | Curr Opin Nephrol Hypertens2006，15，5： | 1 |
| 16 | Angiotensin ]] : a key factor in the inflammatory and fibrotic response in kidney diseases 显示文摘 | Ruiz-Ortega M Ruperez M Esteban V | 2006 | Nephrol Dial Transplant2006，21，1： | 1 |
| 17 | Endothelin-1, via ETA receptor and independently of transforming growth factorbeta, increases the connective tissue growth factor in vascular smooth muscle cells 显示文摘 | Rodriguez-Vita J Ruiz-Ortega M Ruperez M | 2005 | Circ Res2005，97，2： | 1 |
| 18 | Potential antioxidant capacity of sulfated polysaccharides fi'om the edible marine brown seaweed Fucus vesiculosus 显示文摘 | Ruperez P Ahrazem O Leal JA | 2002 | J Agric Food Chem2002，50，4： | 1 |
| 19 | Role of rinin-angioten system in vascular disease显示文摘 | Ruiz-Ortega M Lorenzo O Ruperez M Esteban V Suzuki Y Mezzano S | 2001 | Hypertension2001，38，： | 1 |
| 20 | Angiotensin Ⅱ,via AT1 and AT2 receptors and NF-kappaB pathway,regu lates the inflammatory response in unilateral ureteral obstruction显示文摘 | Lorenzo O Ruperez M | 2004 | J Am Soc Nephrol2004，15，6： | 1 |
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