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| 1 | Whether Probiotic Supplementation Benefits Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis显示文摘Gut and oral microflora are important factors in the pathogenesis and development of rheumatoid arthritis(RA). Recent studies have shown that probiotic supplements have beneficial consequences on experimental arthritis in rats. However, results from randomized clinical trials on the effects of probiotics have not been consistent. The aim of this study was to systematically review the existing evidence for the effects of probiotic intervention in RA. We included randomized controlled trials(RCTs) of RA patients receiving stable treatment with disease-modifying anti-rheumatic drugs(DMARDs) that:(1) were combined with additional probiotic supplements or(2) were combined with either no additional supplements or only a placebo treatment. Statistical analysis was performed using Review Manager 5.3.3.Six randomized clinical trials were eligible for inclusion in the meta-analysis, with 249 participants in total. The results showed that the probiotic intervention treatment has not yet achieved significant improvement in the American College of Rheumatology 20% improvement criteria(ACR20) score and the disease activity score in 28 joints(DAS28). The laboratory index C-reactive protein(CRP)(mg·L–1) was significantly reduced in the intervention group. The expression of inflammatory cytokines tumor necrosis factor(TNF)-α and interleukine(IL)-1β was also significantly reduced, while IL-10 expression increased in the probiotic intervention groups. This article is the first systematic review and meta-analysis providing a comprehensive assessment of the benefits of treating RA with probiotics. We found that probiotic supplementation may show a limited improvement in RA therapy in existing reports because of a lack of sufficiently high-quality work on the part of clinicians. More multi-centered, large-sample RCTs are needed in order to evaluate the benefits of probiotics in RA treatment. | Hudan Pan Runze Li Ting Li Jun Wang Liang Liu | 2017 | Engineering2017，3，1： | 7 |
| 2 | ShadowGAN: Shadow synthesis for virtual objects with conditional adversarial networks显示文摘We introduce ShadowGAN, a generative adversarial network(GAN) for synthesizing shadows for virtual objects inserted in images. Given a target image containing several existing objects with shadows,and an input source object with a specified insertion position, the network generates a realistic shadow for the source object. The shadow is synthesized by a generator; using the proposed local adversarial and global adversarial discriminators, the synthetic shadow's appearance is locally realistic in shape, and globally consistent with other objects' shadows in terms of shadow direction and area. To overcome the lack of training data,we produced training samples based on public 3D models and rendering technology. Experimental results from a user study show that the synthetic shadowed results look natural and authentic. | Shuyang Zhang Runze Liang Miao Wang | 2019 | Computational Visual Media2019，5，1： | 5 |
| 3 | Highly Dispersed Cobalt Nanoparticles Embedded in Nitrogen-Doped Graphitized Carbon for Fast and Durable Potassium Storage显示文摘Potassium-ion batteries(KIBs)have great potential for applications in large-scale energy storage devices.However,the larger radius of K+leads to sluggish kinetics and inferior cycling performance,severely restricting its practical applicability.Herein,we propose a rational strategy involving a Prussian blue analogue-derived graphitized carbon anode with fast and durable potassium storage capability,which is constructed by encapsulating cobalt nanoparticles in nitrogen-doped graphitized carbon(Co-NC).Both experimental and theoretical results show that N-doping effectively promotes the uniform dispersion of cobalt nanoparticles in the carbon matrix through Co-N bonds.Moreover,the cobalt nanoparticles and strong Co-N bonds synergistically form a threedimensional conductive network,increase the number of adsorption sites,and reduce the diffusion energy barrier,thereby facilitating the adsorption and the diffusion kinetics.These multiple effects lead to enhanced reversible capacities of 305 and 208.6 mAh g^−1 after 100 and 300 cycles at 0.05 and 0.1 A g^−1,respectively,demonstrating the applicability of the Co-NC anode for KIBs. | Xiaodong Shi Zhenming Xu Cheng Han Runze Shi Xianwen Wu Bingan Lu Jiang Zhou Shuquan Liang | 2021 | Nano-Micro Letters2021，13，2： | 4 |
| 4 | Author correction to‘Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsisinduced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice'[Acta Pharmaceutica Sinica B 13(2023)1164-1179]显示文摘The authors regret that there were some picture errors in Fig.7C and Supporting Information Fig.S10B owing to the negligence of the picture typesetting and careless mistakes.In Fig.7C,the H&E picture of PBS+Lipo+CLP group was the inverted picture of CLP group in Fig.5G.In Fig.7C,the H&E picture of Clo-Lipo+CLP group was zoom-in picture of L johnsoni+CLP group in Fig.8F.In Fig.SI0B,the H&E picture of ileum in CLP group was zoom-in picture of Anti-IL-10R+CLP group in Fig.S11C.The authors revise the H&E picture of liver in PBS+Lipo+CLP group and the H&E picture of liver in Clo-Lipo+CLP group in Fig.7C.Also,the H&E picture of ileum in CLP group of Fig.S10B have been revised.The correct figures are presented as below. | Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 2 |
| 5 | Variable selection for partially linear models with measurement errors 显示文摘 | LIANG Hua LI Runze | 2009 | Journal of the American Statistical Association2009，104，： | 1 |
| 6 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 7 | 一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统显示文摘文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)成像技术是最常用的诊断技术之一。 | Daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康 | 2019 | 科学新闻2019，0，2： | 1 |
| 8 | Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice显示文摘Sepsis-induced liver injury(SILI)is an important cause of septicemia deaths.BaWeiBaiDuSan(BWBDS)was extracted from a formula of Panax ginseng C.A.Meyer,Lilium brownie F.E.Brown ex Miellez var.viridulum Baker,Polygonatum sibiricum Delar.ex Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)A.DC.,and Cortex Phelloderdri.Herein,we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut microbiota.BWBDS protected mice against SILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal integrity.BWBDS selectively promoted the growth of Lactobacillus johnsonii(L.johnsonii)in cecal ligation and puncture treated mice.Fecal microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis effects.Notably,L.johnsonii significantly reduced SILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal integrity.Furthermore,heat inactivation L.johnsonii(HI-L.johnsonii)treatment promoted macrophage anti-inflammatory activity and alleviated SILI.Our findings revealed BWBDS and gut microbiota L.johnsonii as novel prebiotic and probiotic that may be used to treat SILI.The potential underlying mechanism was at least in part,via L.johnsonii-dependent immune regulation and interleukin-10+M2 macrophage production. | Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 9 | Oxidative exfoliation of spent cathode carbon:A two-in-one strategy for its decontamination and high-valued application显示文摘Spent cathode carbon(SCC)from aluminum electrolysis is a potential graphite resource.However,full use of the SCC remains a challenge,since it contains many hazardous substances(e.g.,fluoride salts,cyanides),encapsulated within the thick carbon layers and thus posing serious environmental concerns.This work presents a chemical oxidative exfoliation route to achieve the recycling of SCC and the decontaminated SCC with high-valued graphene oxide(GO)-like carbon structures(SCC-GO)is applied as an excellent adsorbent for organic pollutants.Specifically,after the oxidative exfoliation,the embedded hazardous constituents are fully exposed,facilitating their subsequent removal by aqueous leaching.Moreover,benefiting from the enhanced specific surface areas along with abundant O-containing functional groups,the as-produced SCC-GO,shows an adsorption capacity as high as 347 mg·g^(-1)when considering methylene blue as a pollutant model,which exceeds most of the recently reported carbon-based adsorbents.Our study provides a feasible solution for the efficient recycling of hazardous carbonaceous wastes. | Runze Chen Yuran Chen Xuemin Liang Yapeng Kong Yangyang Fan Quan Liu Zhenyu Yang Feiying Tang Johnny Muya Chabu Maru Dessie Walle Liqiang Wang | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 10 | Self-confocal NIR-II fluorescence microscopy for multifunctional in vivo imaging显示文摘Fluorescence imaging in the second near-infrared window(NIR-II,900–1880 nm)with less scattering background in biological tissues has been combined with the confocal microscopic system for achieving deep in vivo imaging with high spatial resolution.However,the traditional NIR-IIfluorescence confocal microscope with separate excitation focus and detection pinhole makes it possess low confocal e±ciency,as well as di±cultly to adjust.Two types of upgraded NIR-IIfluorescence confocal microscopes,sharing the same pinhole by excitation and emission focus,leading to higher confocal e±ciency,are built in this work.One type is-ber-pinhole-based confocal microscope applicable to CW laser excitation.It is constructed forfluorescence intensity imaging with large depth,high stabilization and low cost,which could replace multiphotonfluorescence microscopy in some applications(e.g.,cerebrovascular and hepatocellular imaging).The other type is air-pinhole-based confocal microscope applicable to femtosecond(fs)laser excitation.It can be employed not only for NIR-IIfluorescence intensity imaging,but also for multi-channelfluorescence lifetime imaging to recognize different structures with similarfluorescence spectrum.Moreover,it can be facilely combined with multiphotonfluorescence microscopy.A single fs pulsed laser is utilized to achieve up-conversion(visible multiphotonfluorescence)and down-conversion(NIR-II one-photonfluorescence)excitation simultaneously,extending imaging spectral channels,and thus facilitates multi-structure and multi-functional observation. | Jing Zhou Tianxiang Wu Runze Chen Liang Zhu Hequn Zhang Yifei Li Liying Chen Jun Qian | 2024 | Journal of Innovative Optical Health Sciences2024，17，1： | 0 |
| 11 | Predicting Reliability and Remaining Useful Life of Rolling Bearings Based on Optimized Neural Networks显示文摘In this study,an optimized long short-term memory(LSTM)network is proposed to predict the reliability and remaining useful life(RUL)of rolling bearings based on an improved whale-optimized algorithm(IWOA).The multi-domain features are extracted to construct the feature dataset because the single-domain features are difficult to characterize the performance degeneration of the rolling bearing.To provide covariates for reliability assessment,a kernel principal component analysis is used to reduce the dimensionality of the features.A Weibull distribution proportional hazard model(WPHM)is used for the reliability assessment of rolling bearing,and a beluga whale optimization(BWO)algorithm is combined with maximum likelihood estimation(MLE)to improve the estimation accuracy of the model parameters of the WPHM,which provides the data basis for predicting reliability.Considering the possible gradient explosion by training the rolling bearing lifetime data and the difficulties in selecting the key network parameters,an optimized LSTM network called the improved whale optimization algorithm-based long short-term memory(IWOA-LSTM)network is proposed.As IWOA better jumps out of the local optimization,the fitting and prediction accuracies of the network are correspondingly improved.The experimental results show that compared with the whale optimization algorithm-based long short-term memory(WOA-LSTM)network,the reliability prediction and RUL prediction accuracies of the rolling bearing are improved by the proposed IWOA-LSTM network. | Tiantian Liang Runze Wang Xuxiu Zhang Yingdong Wang Jianxiong Yang | 2023 | Structural Durability & Health Monitoring2023，17，5： | 0 |
| 12 | Effect of baffle injectors on the first-order tangential acoustic mode in a cylindrical combustor显示文摘Combustion instability is a very important issue in the development of the propulsion systems used in aerospace. It is very important to associate the high frequency combustion instabilities with the acoustic characteristics of the combustion chamber. In this paper, the effects of various baffle injectors which were installed on the injector faceplate on the first-order tangential acoustic mode were investigated theoretically and experimentally. The effects of the gap between adjacent injectors on the first-order tangential acoustic mode in a cylindrical chamber were considered. The acoustic admittance of the injectors was derived. The results showed that the amplitude and frequency of the first-order tangential acoustic mode increase with the increase in the gap between adjacent injectors, but decrease with the increase in the number and height of the baffles.The baffle injectors have a greater influence on the amplitude and frequency of the first-order tangential acoustic mode than the baffle blades. | Runze DUAN Heng ZHANG Liang TIAN Enyu WANG Liansheng LIU | 2022 | Chinese Journal of Aeronautics2022，35，10： | 0 |
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