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| 1 | A novel pulmonary fibrosis murine model with immune-related liver injury显示文摘Idiopathic pulmonary fibrosis(IPF),characterized by aggravated alveolar destruc-tion and fibrotic matrix deposition,tendentiously experiences the stage called acute exacerbation IPF(AE-IPF)and progresses to multiple organ damage,especially liver injury.Recent studies have found a variety of immune microenvironment disorders associated with elevated IPF risk and secondary organ injury,whereas current animal models induced with bleomycin(BLM)could not completely reflect the pathologi-cal manifestations of AE-IPF patients in clinic,and the exact underlying mechanisms are not yet fully explored.In the current study,we established an AE-IPF model by tracheal administration of a single dose of BLM and then repeated administrations of lipopolysaccharide in mice.This mouse model successfully recapitulated the clinical features of AE-IPF,including excessive intrapulmonary inflammation and fibrosis and extrapulmonary manifestations,as indicated by significant upregulation of Il6,Tnfa,Il1b,Tgfb,fibronectin,and Col1a1 in both lungs and liver and elevated serum aspartate transaminase and alanine transaminase levels.These effects might be attributed to the regulation of Th17 cells.By sharing this novel murine model,we expect to pro-vide an appropriate experimental platform to investigate the pathogenesis of AE-IPF coupled with liver injury and contribute to the discovery and development of targeted interventions. | Kexin Jia Jianzhi Wu Yijie Li Jia Liu Runping Liu Yajie Cai Yinhao Zhang Xiaojiaoyang Li | 2023 | Animal Models and Experimental Medicine2023，6，3： | 1 |
| 2 | Preparation,structural and optical properties of AWO4 (A=Ca,Ba,Sr) nanofilms显示文摘 | ZHANG Guoxin JIA Runping WU Qingsheng | | 0，，123： | 1 |
| 3 | Study of the reaction of proteins with BeryllonⅡ-AlⅢby the Rayleigh light scattering technique and its application显示文摘 | Runping Jia Qianfeng Li | 2001 | Analyst2001，126，： | 1 |
| 4 | ZnW04-Ti02 composite nanofilms: Preparation,morphology, structure and photoluminescentenhancement显示文摘 | Jia Runping Zhang Guoxin Wu Qingsheng | 2007 | Materials Letters2007，61，89： | 1 |
| 5 | Preparation, structural and optical properties of AWO4 ( A = Ca, Ba, Sr) nanofilms 显示文摘 | Zhang Guoxin Jia Runping Wu Qingsheng | 2006 | Materials Science and Engineering B2006，128，： | 1 |
| 6 | Prep- aration, structures and photoluminescent enhancement of Cd- WO4-TiO2 composite nanofilms显示文摘 | Jia Runping Zhang Guoxin Wu Qingsheng Ding Yaping | 2006 | Applied Surface Science2006，253，4： | 1 |
| 7 | Preparation, structural and optical properties of AWO4 (A=Ca,Ba,Sr) nanofilms显示文摘 | Guoxin Zhang Runping jia Qingsheng Wu | 2006 | Materials Science and Engineering B2006，128，： | 1 |
| 8 | Preparation,structural and optical properties of AWO4(A=Ca,Ba,Sr) nanofilms显示文摘 | Zhang Guoxin Jia Runping Wu Qingsheng | 2006 | Materials Science and Engineering B2006，128，13： | 1 |
| 9 | Synthesis of CdS hollow/solid nanospheres and their chain-structures by membrane technique 显示文摘 | Duan Shumin Wu Qingsheng Jia Runping | 2008 | J Nanopart Res2008，10，： | 1 |
| 10 | Edge-enriched N, S co-doped hierarchical porous carbon for oxygen reduction reaction显示文摘The development of carbon materials with high electrochemical performance for next-generation energy device is emerging, especially N, S co-doped carbon materials have sparked intensive attention. However,the exploration of N, S co-doped carbon with well-defined active sites and hierarchical porous structures are still limited. In this study, we prepared a series of edge-enriched N, S co-doped carbon materials through pyrolysis of thiourea(TU) encapsulated in zeolitic imidazolate frameworks(TU@ZIF) composites,which delivered very good oxygen reduction reaction(ORR) performance in alkaline medium with onset potential of 0.94 V vs. reversible hydrogen electrode(RHE), good stability and methanol tolerance. Density functional theory(DFT) calculations suggested that carbon atoms adjacent to N and S are probable active sites for ORR intermediates in edge-enriched N, S co-doped carbon materials because higher electron density can enhance O_(2)adsorption, lower formation barriers of intermediates, improving the ORR performance comparing to intact N, S co-doped carbon materials. This study might provide a new pathway for improving ORR activity by the integration engineering of edge sites, and electronic structure of heteroatom doped carbon electrocatalysts. | Fangfang Chang Panpan Su Utsab Guharoy Runping Ye Yanfu Ma Huajun Zheng Yi Jia Jian Liu | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 11 | A novel Ag/ZnO core-shell structure for efficient sterilization synergizing antibiotics and subsequently removing residuals显示文摘The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution problems.This poses a great threat to human health.If the dosage of antibiotics is reduced by increasing its bactericidal performance,the emergence of drug resistance is certainly delayed,so that there's not enough time for developing drug resistance during treatment.Therefore,we selected typical representative materials of metal Ag and semiconductor ZnO nano-bactericides to design and synthesize Ag/ZnO hollow core-shell structures(AZ for short).Antibiotics are grafted on the surface of AZ through rational modification to form a composite sterilization system.The research results show that the antibacterial efficiency of the composite system is significantly increased,from the sum(34.7%+22.8%-57.5%)of the antibacterial efficiency of AZ and gentamicin to 80.2%,net synergizes 22.7%,which fully reflects the effect of 1+1>2.Therefore,the dosage of antibiotics can be drastically reduced in this way,which makes both the possibility of bacterial resistance and medical expenses remarkably decrease.Subsequently,residual antibiotics can be degraded under simple illumination using AZ-self as a photocatalyst,which cuts off the path of environmental pollution.In short,such an innovative route has guiding significance for drug resistance. | Wenmei Han Wenli Wang Jie Fan Runping Jia Xuchun Yang Tong Wu Qingsheng Wu | 2024 | Green Energy & Environment2024，9，2： | 0 |
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