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| 1 | Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer显示文摘BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and oxaliplatin.Studies have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is limited.AIM To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic factors.METHODS One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively analysed.Oxaliplatin and MMC were used in 68 and 34 patients,respectively.Each patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were noted.Complications were stratified and graded using Clavien/Dindo analysis.Prognostic outcome factors were identified using univariate and multivariate analysis of survival.RESULTS The two groups did not differ significantly regarding baseline characteristics.We found no difference in median overall survival between MMC and oxaliplatin HIPEC.Regarding postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal carcinomatosis.Multivariate analysis of survival confirmed primary distant metastasis and primary tumour resection status to have a significant impact on survival and likewise peritoneal cancer index-scoring regarding peritoneal carcinomatosis.CONCLUSION In this single-institution retrospective review of patients undergoing CRS with either oxaliplatin or MMC HIPEC,overall survival was not different,though oxaliplatin was associated with a higher postoperative complication rate,indicating treatment favourably with MMC.Further studies comparing HIPEC regimens would improve evidence-based decision-making. | Julia Spiegelberg Hannes Neeff Philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 3 |
| 2 | Prostaglandins as endogenous mediators of interleukin production显示文摘 | Runkel S L Chensus S W Phan S H | 1985 | J Immunol1985，136，1： | 2 |
| 3 | Minimally iurasive plate fixation in fermoral shaft fractures 显示文摘 | WENDA K RUNKEL M DEGREIFJ | 1997 | Injury1997，28，1： | 1 |
| 4 | Systemic complication in intramedullary nailing显示文摘 | Runkel M | 1996 | Orthopade1996，25，3： | 1 |
| 5 | Effect of Thermal Annealing and Second Harmonic Generation on Bulk Damage Performance of Rapid Growth KDP Type-I Doublers at 1064 nm显示文摘 | Runkel M J Maricle S M Tortes R A | 2001 | SPIE Proceedings2001，4347，： | 1 |
| 6 | Screening of blood donations by hepatitis C virus polymerase chain reaction (HCV-PCR) improves safety of blood products by window period reduction显示文摘 | Hitzler WE Runkel S | 2001 | Clin Lab2001，47，56： | 1 |
| 7 | The role of the gut in the development of sepsis in acute panceatitis 显示文摘 | Runkel N Moody FG Smith GS | 1991 | Surg Res1991，51，1： | 1 |
| 8 | Operating experience with an on-line vibration control system for PWR main coolant pumps显示文摘 | Runkel J Stegemann D Vortriede A | 1998 | Nuclear Engineering Design1998，183，： | 1 |
| 9 | Laser Conditioning Study of KDP on the Optical Sciences Laser Using Large Area Beams显示文摘 | Runkel M J DeYoreo'J J Sell W D | 1998 | SPIE Proceedings1998，3244，： | 1 |
| 10 | The dnminant alopecia phe- notypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3 显示文摘 | Runkel F Marquardt A Stoeger C | 2004 | Genomics2004，84，5： | 1 |
| 11 | Laser Raster Conditioning of KDP and DKDP Crystals Using XeC1 and Nd: YAG Lasers显示文摘 | Staggs M Yan M Runkel M | 2000 | SPIE Proceedings2000，4347，： | 1 |
| 12 | Bariatric surgery显示文摘 | Runkel N Colombo-Benkmann M Hüttl TP | | 0，，20： | 1 |
| 13 | Toward a transport-based analysis of nutrient spiraling and uptake in streams显示文摘 | RUNKEL R L | 2007 | Limnology and Oceanography: Methods2007，5，： | 1 |
| 14 | Optimal emissions taxation under imperfect competition in a durable good industry显示文摘 | Runkel M | 2004 | Bulletin of Economic Research2004，56，2： | 1 |
| 15 | Bone healing after unreaming intramedullary nailing显示文摘 | Wenda K Ritter G | 1994 | Unfallchirurg1994，97，1： | 1 |
| 16 | Outcome after emergency surgery for cancer of the large intestine显示文摘 | Runkel NS Schlag P Schwarz V | 1991 | Br J Surg1991，78，1： | 1 |
| 17 | Routine HCV PCR screening of blood donations to identify early HCV infection in blood donors lacking antibodies to HCV显示文摘 | Hitzler WE Runkel S | 2001 | Transfusion2001，41，： | 1 |
| 18 | Systematic mutational mapping of sites on human interferon-β-la that are important for receptor binding and functional activity显示文摘 | Runkel L Dedios C Karpusas M | 2000 | Biochemistry2000，39，： | 1 |
| 19 | Retrograde nailing of humeral shaft fractures显示文摘 | Rommens PM Blum J Runkel M | 1998 | Clin Orthop Relat Res1998，35，： | 1 |
| 20 | Indirect MR-arthrography in the follow up of autologous osteochondral transplantation显示文摘 | Herber S Runkel M Pitton M B | 2003 | Rofo2003，175，2： | 1 |
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