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您的检索式：作者名="Runjun Wang"
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| 1 | The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury显示文摘The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao (TLJN), which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) in a rat model of focal cerebral ischemic injury. Xue Sai Tong (XST), comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3, 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST. | Peiman Alesheikh Huiling Tang Pengtao Li Wei Zhang Yanshu Pan Arezou Mashoufi Liyun Zhao Runjun Wang Bo Di Yangyang Yan | 2011 | Neural Regeneration Research2011，6，12： | 1 |
| 2 | Insulin‐like growth factor‐1 secreted by brain microvascular endothelial cells attenuates neuron injury upon ischemia显示文摘 | Jun Wang Yibo Tang Wei Zhang Haiping Zhao Runjun Wang Yangyang Yan Liwei Xu Pengtao Li | 2013 | FEBS J2013，，15： | 1 |
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