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| 1 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 2 | Numerical Simulation of Duct Inlet Noise显示文摘 | Li X D Yan J P Rung T Thiele F | 2000 | CFD Journal2000，9，1： | 1 |
| 3 | Numerical simulation of duct inlet noise显示文摘 | Li X D Yan J P Rung T | 2000 | CFD Journal2000，9，1： | 1 |
| 4 | Copepod hatching success in marine ecosystems with high diatom concentrations 显示文摘 | Irigoien X Harris RP Verheye HM Joly P Runge J Starr M Pond D Campbell R Shreeve R Ward P Smith AN Dam HG Peterson W Tirelli V Koski M Smith T Harbour D Davidson R | 2002 | Nature2002，419，： | 1 |
| 5 | Well-posedness for equilibrium problems and for optimization problems with equilibrium constraints显示文摘 | Fang Y P Hu Rung Huang N J | 2008 | Computers and Mathematics with Applications2008，55，： | 1 |
| 6 | The HvNAC6 transcription factor: a positive regulator of penetration resistance in barley and Arabidopsis显示文摘 | Jensen M K Rung J H Gregersen P L | 2007 | Plant Mol Biol2007，，65： | 1 |
| 7 | Use of serum PIVKA-Ⅱ (DCP) determination for differentiation between benign and ma- lignant liver diseases显示文摘 | Lamerz R Runge M Stieber P | 1999 | Anticancer Res1999，19，4： | 1 |
| 8 | Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway显示文摘 | Madamanchi Suzhen L Cam P Marshall S Runge | 2001 | J Biol Chem2001，276，18： | 1 |
| 9 | Alloptical wavelength conversion with extinction ratio improvement of 100 Gb/s RZ-signals in ultralong bulk semiconductor optical amplifiers显示文摘 | RUNGE P BUNGE C A PETERMANN K | 2010 | IEEE Journal of Quantum Electronics2010，46，6： | 1 |
| 10 | A two-step modelfor senescence triggered by a single critically short telomere显示文摘 | Abdallah P Luciano P Runge K W? er al | 2009 | Nat Cell Biol2009，11，8： | 1 |
| 11 | The HvNAC6 transcription factor: a positive regulator of penetration resistance in barley and Arabidopsis显示文摘 | JENSEN M K RUNG J H GREGERSEN P L | 2007 | Plant Mol Biol2007，65，： | 1 |
| 12 | Factors Affecting Farmers Participation in Agri-environmental Measures:A Northern Italian Perspective显示文摘 | Defrancesco E Gatto P Runge F | 2008 | Journal of Agricultural Economics2008，59，1： | 1 |
| 13 | Factors affectingfarmers' participation in agri-environmental measures: A northern Italian perspective 显示文摘 | Defrancesco E Gatto P Runge F | 2008 | Journal of Agricultural Economics2008，59，1： | 1 |
| 14 | thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aotic smooth muscle eells显示文摘 | Rao GN Delafontaine P Runge MS | 1995 | J Biol Chem1995，270，27： | 1 |
| 15 | The HvNAC6 transcription factor:a positive regulator of penetration resistance in bar-ley and Arabidopsis显示文摘 | Rung J H Gregersen P L etal | 2007 | Plant Mol Biol2007，65，12： | 1 |
| 16 | Abnormal vasoactivehormones and 24hour blood pressure in obstruetive sleepapnea显示文摘 | MOILER D S UND P ST RUNGE B | 2003 | Am J Hypertens2003，16，4： | 1 |
| 17 | Ecological and evolutionary traps显示文摘 | Schlaepfer M A Runge M C Sherman P W | 2002 | Trends Ecol Evol2002，17，10： | 1 |
| 18 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | Sladek R Rocheleau G Rung J Dina C Shen L Serre D Boutin P Vincent D Belisle A Hadjadj S 2007 | 2007 | Nature2007，445，7130： | 1 |
| 19 | The HvNAC6transcription factor:a positive regulator of penetration resistance in barley and Arabidopsis显示文摘 | Jensen M K Rung J H Gregersen P L | 2007 | Plant Mol Biol2007，65，12： | 1 |
| 20 | Use of serum PIVKA - II (DCP) determination for differentiation between benign and malignant liver disease 显示文摘 | Lamerz R Runge M Stieber P | 1999 | Anticancer Res1999，19，4： | 1 |
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