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| 1 | A Review of Research on Warm-Sector Heavy Rainfall in China显示文摘Warm-sector heavy rainfall (WSHR) events in China have been investigated for many years. Studies have investigated the synoptic weather conditions during WSHR formation, the categories and general features, the triggering mechanism, and structural features of mesoscale convective systems during these rainfall events. The main results of WSHR studies in recent years are summarized in this paper. However, WSHR caused by micro- to mesoscale systems often occurs abruptly and locally, making both numerical model predictions and objective forecasts difficult. Further research is needed in three areas:(1) The mechanisms controlling WSHR events need to be understood to clarify the specific effects of various factors and indicate the influences of these factors under different synoptic background circulations. This would enable an understanding of the mechanisms of formation, maintenance, and organization of the convections in WSHR events.(2) In addition to South China, WSHR events also occur during the concentrated summer precipitation in the Yangtze River-Huaihe River Valley and North China. A high spatial and temporal resolution dataset should be used to analyze the distribution and environmental conditions, and to further compare the differences and similarities of the triggering and maintenance mechanisms of WSHR events in different regions.(3) More studies of the mechanisms are required, as well as improvements to the model initial conditions and physical processes based on multi-source observations, especially the description of the triggering process and the microphysical parameterization. This will improve the numerical prediction of WSHR events. | Jianhua SUN Yuanchun ZHANG Ruixin LIU Shenming FU Fuyou TIAN | 2019 | Advances in Atmospheric Sciences2019，36，12： | 13 |
| 2 | SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA显示文摘HBV infection initiates hepatitis B and promotes liver cirrhosis and hepatocellular carcinoma.IFN-α is commonly used in hepatitis B therapy,but how it inhibits HBV is not fully understood.We screened 285 human interferon-stimulated genes(ISGs)for anti-HBV activity using a cell-based assay,which revealed several anti-HBV ISGs.Among these ISGs,SAMD4A was the strongest suppressor of HBV replication.We found the binding site of SAMD4A in HBV RNA,which was a previously unidentified Smaug recognition region(SRE)sequence conserved in HBV variants.SAMD4A binds to the SRE site in viral RNA to trigger its degradation.The SAM domain in SAMD4A is critical for RNA binding and the C-terminal domain of SAMD4A is required for SAMD4A anti-HBV function.Human SAMD4B is a homolog of human SAMD4A but is not an ISG,and the murine genome encodes SAMD4.All these SAMD4 proteins suppressed HBV replication when overexpressed in vitro and in vivo.We also showed that knocking out the Samd4 gene in hepatocytes led to a higher level of HBV replication in mice and AAV-delivered SAMD4A expression reduced the virus titer in HBVproducing transgenic mice.In addition,a database analysis revealed a negative correlation between the levels of SAMD4A/B and HBV in patients.Our data suggest that SAMD4A is an important anti-HBV ISG for use in IFN therapy of hepatitis B and that the levels of SAMD4A/B expression are related to HBV sensitivity in humans. | Yuze Wang Xinrui Fan Yunlong Song Yifei Liu Ruixin Liu Jianfeng Wu Xiaoling Li Quan Yuan Guo Fu Ningshao Xia Jiahuai Han | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 3 | The emergence of chaos in complex dynamical networks 显示文摘 | Zhang Haifeng Wu Ruixin Fu Xinehu | 2006 | Chaos Solitons and Fraetals2006，28，： | 1 |
| 4 | RIN enhances plant disease resistance via root exudate-mediated assembly of diseasesuppressive rhizosphere microbiota显示文摘The RIPENING-INHIBITOR(RIN)transcriptional factor is a key regulator governing fruit ripening.While RIN also affects other physiological processes,its potential roles in triggering interactions with the rhizosphere microbiome and plant health are unknown.Here we show that RIN affects microbiome-mediated disease resistance via root exudation,leading to recruitment of microbiota that suppress the soil-borne,phytopathogenic Ralstonia solanacearum bacterium.Compared with the wild-type(WT)plant,RIN mutants had different root exudate profiles,which were associated with distinct changes in microbiome composition and diversity.Specifically,the relative abundances of antibiosis-associated genes and pathogensuppressing Actinobacteria(Streptomyces)were clearly lower in the rhizosphere of rin mutants.The composition,diversity,and suppressiveness of rin plant microbiomes could be restored by the application of 3-hydroxyflavone and riboflavin,which were exuded in much lower concentrations by the rin mutant.Interestingly,RIN-mediated effects on root exudates,Actinobacteria,and disease suppression were evident from the seedling stage,indicating that RIN plays a dual role in the early assembly of diseasesuppressive microbiota and late fruit development.Collectively,our work suggests that,while plant disease resistance is a complex trait driven by interactions between the plant,rhizosphere microbiome,and the pathogen,it can be indirectly manipulated using'prebiotic'compounds that promote the recruitment of disease-suppressive microbiota. | Keming Yang Ruixin Fu Haichao Feng Gaofei Jiang Omri Finkel Tianyu Sun Mingchun Liu Baowen Huang Shan Li Xiaofang Wang Tianjie Yang Yikui Wang Shimei Wang Yangchun Xu Qirong Shen Ville-Petri Friman Alexandre Jousset Zhong Wei | 2023 | Molecular Plant2023，16，9： | 0 |
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