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| 1 | Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment显示文摘Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field. | Ruixiang Li Yuwei He Shuya Zhang Jing Qin Jianxin Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 36 |
| 2 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 3 | CONDUCTIVITY METHOD APPLIED TO THE STUDY OFINTERACTION BETWEEN ADSORBENT AND ADSORBATE Ⅰ. ADSORPTION OF LOW CONCENTRATION OF FREE ACID BY REGENERABLE CHITIN显示文摘The adsorption of low concentration of free acid by regenerable chitin is followed by electric conductance determination. The effect of acid concentration, content of functional amino groups, and ionic strength on adsorption was discussed. Experimental results indicate that the active centre of regenerable chitin is the free amino groups on its surface, and that the rate of adsorption of free acid was found to be affected by two factors: the interaction between the adsorbent and the adsorbate in solution and that between the adsorbate molecules or ions in solution. | Chen Bingren He Guangping Ling Moyu Wang Ruixiang Chen Wensen (Department of Chemistry, South China Normal University, Guangzhou, 510631) | 1997 | Chinese Journal of Reactive Polymers1997，6，1： | 7 |
| 4 | Efficient Scheduling Mapping Algorithm for Row Parallel Coarse-Grained Reconfigurable Architecture显示文摘Row Parallel Coarse-Grained Reconfigurable Architecture(RPCGRA)has the advantages of maximum parallelism and programmable flexibility.Designing an efficient algorithm to map the diverse applications onto RPCGRA is difficult due to a number of RPCGRA hardware constraints.To solve this problem,the nodes of the data flow graph must be partitioned and scheduled onto the RPCGRA.In this paper,we present a Depth-First Greedy Mapping(DFGM)algorithm that simultaneously considers the communication costs and the use times of the Reconfigurable Cell Array(RCA).Compared with level breadth mapping,the performance of DFGM is better.The percentage of maximum improvement in the use times of RCA is 33%and the percentage of maximum improvement in non-original input and output times is 64.4%(Given Discrete Cosine Transfor 8(DCT8),and the area of reconfigurable processing unit is 56).Compared with level-based depth mapping,DFGM also obtains the lowest averages of use times of RCA,non-original input and output times,and the reconfigurable time. | Naijin Chen Zhen Wang Ruixiang He Jianhui Jiang Fei Cheng Chenghao Han | 2021 | Tsinghua Science and Technology2021，26，5： | 4 |
| 5 | A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver显示文摘尽管纳米技术很快在指向的肿瘤被开发了并且适用,化疗的结果仍然保持极大地在正常纸巾和房间由细胞毒素的药的毒性限制了。因此,与在正常房间的很少副作用,其他的交货系统的开发吸引了增加的注意。精力限制是癌症治疗的一条新奇、有希望的途径,它能经由细胞的精力新陈代谢的抑制限制肿瘤生长。在这研究,指向系统的一个新奇肿瘤,基于叶酸结合牛的浆液白朊(BSA ) ,被开发到共同交付 albendazole 和 nanosilver 同时,制止肿瘤房间的精力新陈代谢。没有 folic 酸修正, nanosilver,或 albendazole,这 nanosystem 用 nanoparticles 比那些显示出更强壮的反肿瘤功效,在 vitro 并且在 vivo。这 nanosystem 弄空经由 glycolytic 酶和 mitochondrial 损坏的直接抑制的细胞的 ATP,导致肿瘤房间的增长,房间周期拘捕,和 apoptosis 的抑制。提高的反肿瘤活动贡献了这个系统的指向肿瘤的能力,导致在肿瘤房间的特定的精力抑制。毒性评估被执行证实这个系统的安全。这 nanosystem 为肿瘤治疗提供有效、安全的策略。 | Jianming Liang Ruixiang Li Yuwei He Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang | 2018 | Nano Research2018，11，9： | 3 |
| 6 | Extensions of a class of semi-continuous fuzzy measures显示文摘 | Li Xiaoqi Wang He Li Ruixiang | 1998 | Fuzzy Sets and Systems1998，94，3： | 1 |
| 7 | Studies on Nuclear Transplantation in Mammalian Embryos显示文摘StudiesonNuclearTransplantationinMammalianEmbryos￥TanJinghe;ZhouQi;ZhangQiuming;HeGuixin;LiuRuixiang;XuLibin;YangChanyunandQi... | Tan Jinghe Zhou Qi Zhang Qiuming He Guixin Liu Ruixiang Xu Libin Yang Chanyun and Qin Pengchun(Northeast Agriculture University Harbin, 150030 P R C ) | 1995 | Journal of Northeast Agricultural University(English Edition)1995，2，1： | 0 |
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