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| 1 | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease显示文摘BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)refers to any fatty liver disease that is not due to excessive use of alcohol.NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance.Aerobic exercise is shown to improve NAFLD.This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.DATA SOURCE:We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub Med. | Rui Guo Emily C Liong Kwok Fai So Man-Lung Fung George L Tipoe | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 16 |
| 2 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 3 | Three decades of hepatitis B control with vaccination显示文摘Hepatitis B virus(HBV) continues to represent a major health problem and can lead to acute liver failure, acute hepatitis, chronic carriership, chronic hepatitis of HBV, liver cirrhosis, liver cancer, liver transplantation and death. There is a marked difference in the geographic distribution of carriers. More than 240 million people worldwide are chronic HBV carriers. Mother-to-child transmission remains the most important mechanism of infection in countries with a high prevalence of HBV. Percutaneous/parenteral transmission and unsafe sexual practices are important mode of spread transmission of HBV in other countries. Vaccination against HBV is the gold measure for primary prevention and control of the disease. Currently, 179 countries have added HBV vaccination to their routine vaccination programs with great results. Neonatal immunization with HBV vaccine has been one of the most highly effective measures in public health and the first anti-cancer program to be launched. In this paper we review the achievements for the last three decades. | Liliane C Meireles Rui Tato Marinho Pierre Van Damme | 2015 | World Journal of Hepatology2015，7，18： | 5 |
| 4 | Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study显示文摘 | Timothy Iveson Ross C Donehower Irina Davidenko Sergey Tjulandin Andrzej Deptala Mark Harrison Somanath Nirni Kuntegowdanahalli Lakshmaiah Anne Thomas Yizhou Jiang Min Zhu Rui Tang Abraham Anderson Sarita Dubey Kelly S Oliner Elwyn Loh | 2014 | Lancet Oncology2014，，9： | 3 |
| 5 | Recent advances in cluster analysis显示文摘 | RUI X DONALD C WUNSCH I | 2008 | International Journal of Intelligent Computing and Cybernetics2008，1，4： | 1 |
| 6 | The 1,4-Naphthoquinone Scaffold in the Design of Cysteine Protease Inhihitors显示文摘 | CLAUDIA V RUI M RITA C | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 7 | V-Src phosphorylation of connexin43 on Tyr247 and Tyr265 disrupts gap junction communication显示文摘 | RUI L BONNIE J WARN C | 2001 | The Journal of Cell Biology2001，154，4： | 1 |
| 8 | Optimization of polyhydroxybutyrate production by mixed cultures submitted to aerobic synamic feeding conditions 显示文摘 | Luisa S Serafim Paulo C Lemos Rui Oliveira | 2004 | Biotechnology and Bioengineering2004，87，2： | 1 |
| 9 | Effects of acute stress]on blood dotting and yeast killing by phagocytes of rainbow trout显示文摘 | RUIS M A W BAYNE C J | 1997 | Journal of Aquatic Animal Health1997，9，： | 1 |
| 10 | Probable risk factors for postoperative delirium in patients undergoing spinal surgery 显示文摘 | Rui C Yang ZZ Li M | 2008 | Eur SpineJ2008，17，11： | 1 |
| 11 | Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report显示文摘 | Ruis C van den Berg E van Zandvoort MJ | 2012 | Appl Neuropsychol Adult2012，19，： | 1 |
| 12 | Zeolite thin films; from computer chips to space stations显示文摘 | Lew C M Cai Rui Yan Yushan | 2009 | Accounts of Chemical Research2009，43，2： | 1 |
| 13 | Coal liquefaction, Shenhua Group, and Chinas energy security显示文摘 | Peter N Alan S Rui H C | 2004 | European Management Journal2004，22，2： | 1 |
| 14 | A land use change model:Integrating land- scape pattern indexes and Markov-CA显示文摘 | Xin Y Xin Q Z Rui C | 2014 | Ecological Modelling2014，283，： | 1 |
| 15 | Efficiency and its determinants in Portuguese hotels in the Algarve显示文摘 | Ricardo O Maria Isabel P Rui C M | 2013 | Tourism Management2013，36，2： | 1 |
| 16 | Principal component analysis as tool of characterization of quince (Cydonia oblonga Miller) jam 显示文摘 | Branca M S Paula B A Rui C M | 2006 | Food Chemistry2006，94，4： | 1 |
| 17 | Stroke Awareness in urban and Rural Populations from Northern Portugal:knowledge and action are independent显示文摘 | Mília M Manuel C Rui M | 2011 | Neuroepidemiology2011，36，4： | 1 |
| 18 | Mild depressive symptoms do not influence cognitive functioning in patients with type 2 dia- betes 显示文摘 | Koekkoek PS Rutten GE Ruis C | 2013 | Psychoneuroendocrinology2013，38，3： | 1 |
| 19 | V2O3 modified LiFePO4/C composite with improved electrochemical performance显示文摘 | Jin Y Yang C P Rui X H | | 0，，13： | 1 |
| 20 | Cognitive dysfunction in patients with type 2 diabetes显示文摘 | Reijmer YD van den Berg E Ruis C | 2010 | Diabetes Metab Res Rev2010，26，7： | 1 |
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