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| 1 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 2 | Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets显示文摘 | Chen-Yu Zhang Laura E. Parton Chian Ping Ye Stefan Krauss Ruichao Shen Cheng-Ting Lin John A. Porco Bradford B. Lowell | 2006 | Cell Metabolism2006，，6： | 3 |
| 3 | China’s new problems of food security revealed by the Food Equivalent Unit显示文摘China's food security has a great influence on the world,and has always been the top priority in China.In recent years,as the concept of food security is evolving into one of nutrition security and the importance of food diversity is increasing,research based on nutrition security and broad food systems are increasingly needed in today’s China.Thus,not only grain for human consumption,but also animal foods have been integrated into the Food Equivalent,which is used to analyze China’s current agriculture system and reveal the water resource distribution.The results indicated that the average animal food consumption has risen by 78.6%,and now China’s daily supply of animal food per capita has reached about 50%of that in the USA and 80%of that in the South Korea.So there exist an obvious disparity in animal food supply between China and these two countries.It is impossible for the China’s current agricultural system to achieve the level in the USA.Under China’s current agricultural system,the consumption proportion of feed grain had surpassed the consumption of food grain,increased sharply from 33%in 1992 to 67%in 2011.However,the growth potential of total grain output is approaching an upper limit,so the continued growth of feed grain demand exerts great pressure on the China’s food supply.The discordance of the spatial distribution of water resource and virtual water revealed that China’s current agriculture system had a low efficiency in being able to achieve food and nutrition security.China’s current“grain farming”cannot meet the demand of increasing nutrition and appropriate resource utilization.The implementation of grassland agriculture appears feasible and necessary for saving feed grain,providing a large number of high-quality animal foods and appropriate water resource utilization. | Huilong LIN Ruichao LI Cangyu JIN Chong WANG Maohong WEI Jizhou REN | 2014 | Frontiers of Agricultural Science and Engineering2014，1，1： | 2 |
| 4 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 5 | Evolution-driven crosstalk between glioblastoma and the tumor microenvironment显示文摘Glioblastoma(GBM)is a malignant adult brain tumor for which 90%of patients experience recurrence within a year after surgery1.Evolution confers treatment resistance capabilities on tumors2.The diversification of malignant and non-malignant(i.e.,stromal and immune cell)compartments in the tumor microenvironment(TME)during tumor evolution3-7 eventually results in the formation of a complex interaction network that promotes tumor progression. | Lingxiang Wu Ruichao Chai Zihan Lin Rongrong Wu Diru Yao Tao Jiang Qianghu Wang | 2023 | Cancer Biology & Medicine2023，20，5： | 0 |
| 6 | Effects of inter-layer remelting frequency on the microstructure evolution and mechanical properties of equimolar CoCrFeNiMn high entropy alloys during in-situ powder-bed arc additive manufacturing(PBAAM)process显示文摘An equiatomic CoCrFeNiMn High Entropy Alloy(HEA)was in-situ deposited by the powder-bed arc ad-ditive manufacturing(PBAAM)process for the first time.Comparative research was conducted on the evolution of phase,crystallographic orientation,dislocation morphology,precipitation,and mechanical performance with the accumulation of inter-layer remelting times.The experimental outcomes mani-fested that the PBAAMed CoCrFeNiMn HEA consists of a stable solid-solution FCC structure,with de-creased lattice parameter but slightly increased(full width at half maximum)FWHM as the accumulation of the inter-layer remelting.The{001}<100>cube texture with a weakened texture intensity was de-tected with an increment of inter-layer remelting frequency from once to 5 times,yet it was transformed into{011}<100>Goss texture with a further increase to 7 times.Additionally,the mean grain diameter distinctly decreased,while the volume fraction of(low angle grain boundaries)LAGBs and dislocation density remarkably added up as the accumulated inter-layer remelts.Predominant cellular substructure generated in all process conditions and could be easily differentiated by elemental segregation.Both theσand M 23 C 6 Cr-rich precipitates in nano-scale and submicron MnS precipitate were detected on the grain boundaries of the PBAAMed deposited components,with a rather sparse distribution.Speaking of mechanical performance,the YS,UTS,and hardening rate are generally increased while the UE is grad-ually decreased as increased inter-layer remelting times.The studied PBAAMed CoCrFeNiMn HEA pos-sesses comparable mechanical performances with the counterparts of laser-deposited and as-cast ones.The strengthening mechanisms of the studied material are predominantly the grain boundary strength-ening and dislocation strengthening.This investigation would be a valuable resource in the research field of fabricating HEA alloys with acceptable microstructure and properties using the PBAAM method. | Jun Wang Yao Lu Fanghui Jia Wenzhen Xia Fei Lin Jian Han Ruichao Wang Zengxi Pan Huijun Li Zhengyi Jiang | 2022 | Journal of Materials Science & Technology2022，，18： | 0 |
| 7 | Allocation of grassland, livestock and arable based on the spatial and temporal analysis for food demand in China显示文摘To explore the distribution of food demand and the projected trend in future food demand in China, this paper analyzed the change in current(1998–2012) percapita demand for grain, grain-consuming and herbivorous livestock products, and predicted the food demand in 2020 The results indicated that in 1998–2012, the national percapita consumption of grain ration declined by about36.66%, and the per-capita consumption of grain-consuming and herbivorous livestock products increased by about 48% and 34.09%, respectively. The grain-consuming livestock products have become the primary source of both calories and protein for consumers. The proportion of herbivorous livestock products in consumer diets has increased steadily and there has been huge potential in substituting beef and mutton for pork in this dynamic market. The demand for food in different regions of China is highly variable, which is important for planning grassland agriculture development and ensuring food safety. The demand for grain, and grain-consuming and herbivorous livestock products will increase by about3.3%, 20% and 14% respectively by 2020. Based on the food demand and trend in the development of grassland agriculture, the 31 regions in China are divided into three priority groups for grassland agriculture development. | Huilong LIN Ruichao LI Yifan LIU Jingrong ZHANG Jizhou REN | 2017 | Frontiers of Agricultural Science and Engineering2017，4，1： | 0 |
| 8 | Pedestrian and Vehicle Detection Based on Pruning YOLOv4 with Cloud-Edge Collaboration显示文摘Nowadays,the rapid development of edge computing has driven an increasing number of deep learning applications deployed at the edge of the network,such as pedestrian and vehicle detection,to provide efficient intelligent services to mobile users.However,as the accuracy requirements continue to increase,the components of deep learning models for pedestrian and vehicle detection,such as YOLOv4,become more sophisticated and the computing resources required for model training are increasing dramatically,which in turn leads to significant challenges in achieving effective deployment on resource-constrained edge devices while ensuring the high accuracy performance.For addressing this challenge,a cloud-edge collaboration-based pedestrian and vehicle detection framework is proposed in this paper,which enables sufficient training of models by utilizing the abundant computing resources in the cloud,and then deploying the well-trained models on edge devices,thus reducing the computing resource requirements for model training on edge devices.Furthermore,to reduce the size of the model deployed on edge devices,an automatic pruning method combines the convolution layer and BN layer is proposed to compress the pedestrian and vehicle detection model size.Experimental results show that the framework proposed in this paper is able to deploy the pruned model on a real edge device,Jetson TX2,with 6.72 times higher FPS.Meanwhile,the channel pruning reduces the volume and the number of parameters to 96.77%for the model,and the computing amount is reduced to 81.37%. | Huabin Wang Ruichao Mo Yuping Chen Weiwei Lin Minxian Xu Bo Liu | 2023 | Computer Modeling in Engineering & Sciences2023，，11： | 0 |
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