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| 1 | Role of systemic inflammation in cirrhosis:From pathogenesis to prognosis显示文摘The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted. | Melisa Dirchwolf Andres Eduardo Ruf | 2015 | World Journal of Hepatology2015，7，16： | 18 |
| 2 | Immunobiology and immunotherapy of HCC:spotlight on innate and innate-like immune cells显示文摘Immune-based therapies such as immune checkpoint inhibitors have revolutionized the systemic treatment of various cancer types.The therapeutic application of monoclonal antibodies targeting inhibitory pathways such as programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)and CTLA-4 to cells of the adaptive immune system has recently been shown to generate meaningful improvement in the clinical outcome of hepatocellular carcinoma(HCC).Nevertheless,current immunotherapeutic approaches induce durable responses in only a subset of HCC patients.Since immunologic mechanisms such as chronic inflammation due to chronic viral hepatitis or alcoholic and nonalcoholic fatty liver disease play a crucial role in the initiation,development,and progression of HCC,it is important to understand the underlying mechanisms shaping the unique tumor microenvironment of liver cancer.The liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial,viral,and fungal antigens through the gut-liver axis.Here,we summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them.We also discuss current immunotherapeutic strategies in HCC and outline recent advances in our understanding of how the therapeutic potential of these agents might be enhanced. | Benjamin Ruf Bernd Heinrich Tim F.Greten | 2021 | Cellular & Molecular Immunology2021，18，1： | 18 |
| 3 | An Empirical Investigation of the Relationship Between Change in Corporate Social Performance and Financial Performance: A Stakeholder Theory Perspective显示文摘 | Bernadette M. Ruf Krishnamurty Muralidhar Robert M. Brown Jay J. Janney Karen Paul | 2001 | Journal of Business Ethics2001，，2： | 4 |
| 4 | 论“数字化大学”的内涵及发展显示文摘为遏制新冠疫情实施的措施导致高校转向纯数字化教学,这也给全球的高等教育系统带来了一项新挑战。在极短的时间内,各高校不仅必须设计出一个以线上教学为基准的教学结构,而且还必须在极短的时间内实施。基于对大学的理解为出发点描述了这一情形,并试图提出一种可以被称为“数字化大学”的观点。 | Oliver Ruf 陈颖(翻译) | 2022 | 应用型高等教育研究2022，7，1： | 2 |
| 5 | Protein-losing pseudomembranous colitis with cap polyposis-like features显示文摘Protein-losing enteropathy(PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved colon was performed and the symptoms were significantly resolved. The final histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features. Such a cause of PLE has never been described before. | Wolfgang Kreisel Guenther Ruf Richard Salm Adhara Lazaro Bertram Bengsch Anna-Maria Globig Paul Fisch Silke Lassmann Annette Schmitt-Graeff | 2017 | World Journal of Gastroenterology2017，23，16： | 2 |
| 6 | Prevalence of WTI mutations in a large cohort of patients with steroid - resistant and steroid - sensitive nephrotic syndrome 显示文摘 | Ruf RG Schultheiss M | 2004 | Kidney Int2004，66，2： | 1 |
| 7 | Homogeneous catalysis by evaporated solids 显示文摘 | Ruf S Emig G | 1999 | Journal of Molecular Catalysis A:Chemical1999，146，12： | 1 |
| 8 | Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model显示文摘 | Vogelmann R Ruf D Wagner M | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，1： | 1 |
| 9 | Course of platelet activation markers after ischemic stroke显示文摘 | Marquardt L Ruf A Mansmann U | 2002 | Stroke2002，33，11： | 1 |
| 10 | Chiral station phase for LC and SFC obtained by “polymer coating”显示文摘 | RUFFING F J LUX J A ROEDER W | 1988 | Chromatographia1988，26，： | 1 |
| 11 | Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicy显示文摘 | RUF W SEFTOR E A PETROVAN R J | 2003 | Cancer Res2003，63，17： | 1 |
| 12 | Constrained Gaussian mixture model framework for automatic segmentation of MR brain images显示文摘 | Greenspan H Ruf A Goldberqer J | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 13 | Hemivertebra resection and osteotomies in congenital spine deformity显示文摘 | Ruf M Jensen R Letko L | | 0，，1976： | 1 |
| 14 | Tissue factor and cancer显示文摘 | Ruf W | 2012 | Thromb Res2012，130，1： | 1 |
| 15 | Quantitative and stoichiometric analysis of the microRNA content of exosomes显示文摘 | Chevillet JR Kang Q Ruf IK | 2014 | Proc Natl Acad Sci U S A2014，111，14： | 1 |
| 16 | Anhydrous formaldehyde by sodium catalysis 显示文摘 | Ruf S May A Emig G | 2001 | Applied Catalysis A:General2001，213，2： | 1 |
| 17 | Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone显示文摘 | RUF A E KREMERS W K CHAVEZ L L | 2005 | Liver Transpl2005，11，3： | 1 |
| 18 | A biological classification concep t for the assessment of soil quality:'biological soil classification scheme'显示文摘 | RUF A BECK L DREHER P | 2003 | Agriculture Ecosystem andEnvironment2003，98，： | 1 |
| 19 | Hemivertebra resection by posterior approach innovative operative technique and first resuhs 显示文摘 | Ruf M Harms J | 2002 | Spiae2002，27，： | 1 |
| 20 | Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit 显示文摘 | Ruf S Hermann M Berger I J | 2001 | Natl Biotechn2001，19，9： | 1 |
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