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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 3 | 起止点炎的影像学检查——一个新的研究领域显示文摘 | Hermann KGA Eshed I Bollow M 杨岷(译) 夏黎明(校) | 2006 | 放射学实践2006，21，9： | 2 |
| 4 | Measurement of bound states in the continuum by a detector embedded in a photonic crystal显示文摘We directly measure optical bound states in the continuum(BICs)by embedding a photodetector into a photonic crystal slab.The BICs observed in our experiment are the result of accidental phase matching between incident,reflected and in-plane waves at seemingly random wave vectors in the photonic band structure.Our measurements were confirmed through a rigorously coupled-wave analysis simulation in conjunction with temporal coupled mode theory.Polarization mixing between photonic crystal slab modes was observed and described using a plane wave expansion simulation.The ability to probe the field intensity inside the photonic crystal and thereby to directly measure BICs represents a milestone in the development of integrated opto-electronic devices based on BICs. | Roman Gansch Stefan Kalchmair Patrice Genevet Tobias Zederbauer Hermann Detz Aaron M Andrews Werner Schrenk Federico Capasso Marko Lončar Gottfried Strasser | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 5 | Research on infectious bursal disease—the past, the present and the future显示文摘 | Hermann Müller Md.Rafiqul Islam Rüdiger Raue | 2003 | Veterinary Microbiology2003，，1： | 2 |
| 6 | A new laboratory EUV reflectometer for large optics using a laser plasma source显示文摘 | LUDWING V L THOMAS B HERMANN M | 2003 | SPIE2003，5038，： | 2 |
| 7 | Research on infectious bursal disease—the past, the present and the future显示文摘 | Hermann Müller Md.Rafiqul Islam Rüdiger Raue | 2003 | Veterinary Microbiology2003，，1： | 2 |
| 8 | Platelet CD40 ligand(CD40L)-subcellular localization,regulation of expression,and inhibition by clopidogrel显示文摘 | Hermann A Rauch BH Braun M | 2001 | Platelets2001，12，2： | 1 |
| 9 | Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire 显示文摘 | Eckhart L Ballaun C Hermann M | 2008 | Mol Biol Evol2008，25，5： | 1 |
| 10 | Cognitive prognosis in chronic temporal lobe epilepsy显示文摘 | Hermann BP Seidenberg M Dow C | 2006 | Annals of Neurology2006，60，1： | 1 |
| 11 | Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit 显示文摘 | Ruf S Hermann M Berger I J | 2001 | Natl Biotechn2001，19，9： | 1 |
| 12 | Laryngeal recurrent nerve injury in surgery for benign thyroid diseases: effect of nerve dissection and impact of individual surgeon in more than 27,000 nerves at risk 显示文摘 | Hermann M Alk G Roka R | 2002 | Ann Surg2002，235，2： | 1 |
| 13 | Defining active saeroiliitis on magnetic resonance imaging (MR/) for classifica- tion of axial Spondylarthritis:a consensual approach by the ASAS/OMERACT MR1 group 显示文摘 | Rudwaleit M Jurik AG Hermann KG | 2009 | Ann Rheum Dis2009，68，： | 1 |
| 14 | Neuromonitoring in thyroid surgery:prospective evaluation of intraoperative electrophysiological responses for the prediction of recurrent laryngeal nerve injury显示文摘 | Hermann M Hellebart C Freissmuth M | | 0，，： | 1 |
| 15 | Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding proteim3 in human osteosarcoma cells显示文摘 | Micutkova L Hermann M Offterdinger M | 2012 | Int J Cancer2012，130，7： | 1 |
| 16 | Incidental papillary mierocarcinoma of the thyroid-further evidence of a very low malignant potential: a retrospective clinicopathologieal study with up to 30 years of follow-up 显示文摘 | Neuhold N Schultheis A Hermann M | 2011 | Ann Surg Oncol2011，18，12： | 1 |
| 17 | Digital mammography: current state and future aspects 显示文摘 | Fischer U Hermann KP Baμm F | 2006 | Eur Radiol2006，16，1： | 1 |
| 18 | Principles of therapeutics of galanthamine显示文摘 | Muche M | 1997 | Drugs Today1997，33，4： | 1 |
| 19 | Laryngeal recurrent nerve injury in surgery for benign thyroid diseases:effect of nerve dissection and impact of individual surgeon in more than 27,000 nerves at risk显示文摘 | Hermann M Alk G Roka R | 2002 | Ann Surg2002，235，2： | 1 |
| 20 | Effects of post-harvest treatment sonthe carbohydrate composition of yacon roots in the PeruvianAnde 显示文摘 | Graefe S Hermann M | 2004 | Field Crops Res2004，86，： | 1 |
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