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| 1 | Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases. | Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci | 2014 | World Journal of Clinical Oncology2014，5，3： | 18 |
| 2 | H pylori status and angiogenesis factors in human gastric carcinoma显示文摘AIM: To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phospho- rylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. METHODS: Angiogenic markers were analyzed immu- nohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELI- SA, respectively. RESULTS: A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was signifi cantly associ- ated with cagA (P = 0.0001). MVD was signifi cantly cor- related with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041).Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). CONCLUSION: H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic character- istics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical dis- ease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. | Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 3 | Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications显示文摘Autosomal dominant osteopetrosis type 2 (ADO2) is a high-density brittle bone disease characterized by bone pain,multiple fractures and skeletal-related events,including nerve compression syndrome and hematological failure.We demonstrated that in mice carrying the heterozygous Clcn7^G213R mutation,whose human mutant homolog CLCN7^G215R affects patients,the clinical impacts of ADO2 extend beyond the skeleton,affecting several other organs.The hallmark of the extra-skeletal alterations is a consistent perivascular fibrosis,associated with high numbers of macrophages and lymphoid infiltrates.Fragmented clinical information in a small cohort of patients confirms extra-skeletal alterations consistent with a systemic disease,in line with the observation that the CLCN7 gene is expressed in many organs.ADO2 mice also show anxiety and depression and their brains exhibit not only perivascular fibrosis but also β-amyloid accumulation and astrogliosis,suggesting the involvement of the nervous system in the pathogenesis of the ADO2 extra-skeletal alterations.Extra-skeletal organs share a similar cellular pathology,confirmed also in vitro in bone marrow mononuclear cells and osteoclasts,characterized by an impairment of the exit pathway of the Clcn7 protein product,ClC7,through the Golgi,with consequent reduced ClC7 expression in late endosomes and lysosomes,associated with high vesicular pH and accumulation of autophagosome markers.Finally,an experimental siRNA therapy,previously proven to counteract the bone phenotype,also improves the extra-skeletal alterations.These results could have important clinical implications,supporting the notion that a systematic evaluation of ADO2 patients for extra-skeletal symptoms could help improve their diagnosis,clinical management,and therapeutic options. | Antonio Maurizi Mattia Capulli Annabel Curle Rajvi Patel Argia Ucci Juliana Alves Cotes Harriet Oxford Shireen R. Lamandé John F. Bateman Nadia Rucci Anna Teti | 2019 | Bone Research2019，7，2： | 3 |
| 4 | Embryological study of the glottic site and clinical implications 显示文摘 | RUCCI L ROMAGNOLI P CASUCCI A | 2004 | Oral Oncol2004，40，10： | 1 |
| 5 | Evaluation of metastatic potential in prostate carcinoma: an in vivo model显示文摘 | Angelucci A Gravina GL Rucci N | 2004 | Int J Oncol2004，25，6： | 1 |
| 6 | The Employee- customer- profit Chain at Sears显示文摘 | Rucci Anthony Kim Steven Otiirm Rued | 1998 | Harvard Business Review1998，，： | 1 |
| 7 | Receptor activator of NF-kappa B ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147显示文摘 | Rucci N Millimaqqi D Mari M | 2010 | Cancer Res2010，70，15： | 1 |
| 8 | Reliability and validity of the panic disorder severity scale: Replication and extension显示文摘 | Shear M K Rucci P Williams J | 2001 | Journal of psychiatric Research2001，35，： | 1 |
| 9 | Evaluation of metastatic potential in prostate carcinoma:an in vivo model 显示文摘 | ANGELUCCI A GRAVINA G L RUCCI N | 2004 | Int J Oncol2004，25，6： | 1 |
| 10 | Fas and Fas ligand expression in fetal and adult human testis with normal or derangedspermatogenesis显示文摘 | Francavilia S D'Arizio P Rucci N | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 11 | Complicated Grief and Suicidality: The Impact of Subthreshold Mood Symptoms 显示文摘 | Dell'osso L Carmassi C Rucci P | 2011 | CNS Speetr2011，16，1： | 1 |
| 12 | Roles of metalloproteases in meta- static niche 显示文摘 | Rucci N Sanitd P Angelucci A | 2011 | C urr Mol Med2011，11，8： | 1 |
| 13 | Im-paired skeletal development in interieukin-6-transgenicmice:a model for the impact of chronic inflammation onthe growing skeletal system显示文摘 | DeBenedetti F Rucci N Del Fattore A | 2006 | Arthritis Rheum2006，54，11： | 1 |
| 14 | Validity and reliability of the Italian version of the Chronic Liver Disease Question-naire (CLDQ-I) for the assessment of health-related quality of life 显示文摘 | Rucci P Taliani G Cirrineione L | 2005 | Digestive and liver disease2005，37，11： | 1 |
| 15 | The orthogonal two-needle technique: A new axillary approach to the brachial plexus 显示文摘 | Boccaccini A Doni L Pippa P | 1995 | Eur J Anaesthesiol1995，12，： | 1 |
| 16 | Determinants of cesarean delivery: a classification tree analysis显示文摘 | Stivanello E Rucci P Lenzi J | 2014 | BMC Pregnancy and Childbirth2014，14，： | 1 |
| 17 | Continuity of care in children with special healthcare needs:a qualitative study of family's perspectives显示文摘 | Zanello E Calugi S Rucci P | 2015 | Ital J Pediatr2015，41，1： | 1 |
| 18 | Inhibition of protein kinase c-Src reduces the incidence of breast cancer metas-tases and increases survival in mice: implications for therapy显示文摘 | RUCCI N RECCHIA I ANGELUCCI A | 2006 | J Pharmacol Exp Ther2006，318，1： | 1 |
| 19 | Clinical practice and epidemiology in mental health:CP&EMH显示文摘 | Marazziti D Dell’Osso B Baroni S Mungai F Catena M Rucci P Albanese F Giannaccini G Betti L Fabbrini L Italiani P Del Debbio A Lucacchini A Dell’Osso L | 2006 | 2:282006，2，： | 1 |
| 20 | Homozygous DNA ligase iv r278h mutation in mice leads to leaky scid and repre- sents a model for human lig4 syndrome 显示文摘 | Rucci F Notarangelo LD Faseli A | 2010 | Prec Nail Acad Sci U S A2010，107，7： | 1 |
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