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| 1 | Sugar Input, Metabolism, and Signaling Mediated by Invertase: Roles in Development, Yield Potential, and Response to Drought and Heat显示文摘转化酶(INV ) 水解蔗糖进在主要新陈代谢和植物开发的葡萄糖和果糖的、从而玩的关键角色。基于他们的 pH optima 和亚 cellular 地点, INV 被分成房间墙,细胞质,并且 vacuolar 亚群,分别地作为 CWIN, CIN,和 VIN 缩短了。在植物开发和庄稼生产率的 INV 的宽广重要性和含意吸引了庞大的兴趣从多重观点检验 INV 功能和规定。这里,我们考察在最后二十年在这个区域使进展激动的一些,集中于( 1 )在在translational以后的植物开发和规定的 INV 的新或新兴的角色通过和禁止者的相互作用铺平,( 2 )在 调停INV 的糖发信号之间的串音和开发的神经质的控制,并且( 3 )对种子和水果上的干旱和热压力和他们的影响的调停糖、 调停INV 的回答设定。最后,我们讨论为解开从这新进步和轮廓未来方向产生的主要问题在植物生物工学和农业位于调停 INV 的植物开发和他们的潜在的应用下面的机制。 | Yong-Ling Ruan Ye Jin Yue-Jian Yang Guo-Jing Li John S. Boyer | 2010 | Molecular Plant2010，3，6： | 98 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | Synthesis and paste properties of octenyl succinic anhydride modified early Indica rice starch显示文摘Octenyl succinic anhydride (OSA) modified early Indica rice starch was prepared in aqueous slurry systems using response surface methodology. The paste properties of the OSA starch were also investigated. Results indicated that the suitable parameters for the preparation of OSA starch from early Indica rice starch were as follows: reaction period 4 h, reaction tem- perature 33.4 °C, pH of reaction system 8.4, concentration of starch slurry 36.8% (in proportion to water, w/w), amount of OSA 3% (in proportion to starch, w/w). The degree of substitution was 0.0188 and the reaction efficiency was 81.0%. The results of paste properties showed that with increased OSA modification, the starch derivatives had higher paste clarity, decreased retro- gradation and better freeze-thaw stability. | SONG Xiao-yan CHEN Qi-he RUAN Hui HE Guo-qing XU Qiong | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 51 |
| 4 | 膳食纤维的国内外研究现状与发展趋势显示文摘系统而简要介绍了膳食纤维的国内外研究现状与发展趋势 ,其中包括其组成与分类、分离制备、理化性质、分析鉴定、生理功能。 | 刘伟 刘成梅 林向阳 Roger Ruan | 2003 | 粮食与食品工业2003，10，4： | 59 |
| 5 | Protective effects of nitric oxide on salt stress-induced oxidative damage to wheat (Triticum aestivum L.)leaves显示文摘The changes of chlorophyll and malondialde-hyde (MDA) contents, plasma membrane permeability confirmed that 0.1 and 1 mmol/L sodium nitroprusside (SNP), a donor of nitric oxide (NO) in vivo, could markedly alleviate the oxidative damage to wheat (Triticum aestivum L.) leaves induced by 150 and 300 mmol/L NaCl treatments, respectively. Further results proved that NO significantly enhanced the activities of superoxide dismutase (SOD) and catalase (CAT), both of which separately contributed to the delay of O2- and H2O2 accumulation in wheat leaves under saltstress. Meanwhile, the accumulation of proline was apparently accelerated. Therefore, these results suggested that NO could strongly protect wheat leaves from oxidative damage caused by salt stress. | Haihua Ruan Wenbiao Shen Maobing Ye Langlai Xu | 2002 | Chinese Science Bulletin2002，47，8： | 37 |
| 6 | OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice显示文摘 | Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas Pamela C. Ronald | 2008 | Molecular Plant2008，1，3： | 39 |
| 7 | Overexpression of a Potato Sucrose Synthase Gene in Cotton Accelerates Leaf Expansion, Reduces Seed Abortion, and Enhances Fiber Production显示文摘蔗糖 synthase (怀疑) 是在蔗糖的故障的关键酶并且为水池力量被认为一个生物化学的标记特别在庄稼种类,基于 mutational 和基因,抑制学习。它留下逃犯,然而是否,或到什么程度,的增加怀疑活动可以提高水池开发。我们由表示一个土豆瞄准了这个问题到地址在怀疑表达式的棉花怀疑基因以前被显示了为正常批评种子和纤维开发。那增加了的在产生在揭示的同型结合的子孙线由研究跟随了的 T1 的分离分析在提高的棉花(1 ) 怀疑活动有从从射击顶出现的年轻叶子明显的效果的叶扩大;(2 ) 早改善了种子开发,减少了种子流产,因此提高了种子集合,并且(3 ) 支持的纤维延伸。在年轻叶子怀疑 overexpressing 线,果糖而,集中显著地被增加,在伸长纤维,果糖并且葡萄糖层次被增加。自从 hexoses,在叶子贡献很少到 osmolality,与开发纤维相对照,高怀疑活动,这被结束独立于渗透的规定支持叶开发,可能通过糖发信号。分析也证明在 0-d 棉花种子加倍 Sus 活动增加了他们的新鲜重量大约 30% 。然而,进一步增加在怀疑活动没更进一步在种子重量导致增加,为 Sus overexpression 效果显示上面的限制。最后,从增加的纤维长度和种子数字基于纤维上的观察添加剂效果让步,新策略被建议由总体上,而非完全改进种子开发增加棉花纤维产量集中于操作纤维生长。 | Shou-Min Xu Elizabeth Brill Danny J. Llewellyn Robert T. Furbank Yong-Ling Ruan | 2012 | Molecular Plant2012，5，2： | 35 |
| 8 | HS-SPME-GC-MS联用分析美国巴旦木香气成分显示文摘采用顶空固相微萃取和气相色谱-质谱联用方法分析美国巴旦木的挥发性成分,探讨不同萃取头、萃取时间、萃取温度和分流比对分析结果的影响。得到顶空固相微萃取的最优参数:DVB/CAR/PDMS萃取头、萃取温度80℃、萃取时间15?min、分流比5∶1。最佳萃取条件下分别对美国生巴旦木和烘烤巴旦木的挥发性成分进行分析,得到44种生巴旦木挥发性成分和57种烘烤巴旦木挥发性成分,生巴旦木的主要特征香气成分为正己醇、庚醇、正戊醇、壬醇、乙酸乙酯、乙酸丁酯、甲苯等。烘烤巴旦木的主要特征香气成分为正己醇、庚醇、正戊醇、壬醇、乙酸乙酯、乙酸丁酯、乙酸、3-甲基-丁醛、正己醛、糠醛、苯甲醛、苯乙醛、壬醛、2,5-二甲基吡嗪和2-戊基呋喃等。本实验为美国巴旦木挥发性成分的分析建立了快速分析鉴定的方法。 | 卢静茹 林向阳 张如 吴佳 戴巧玲 罗登来 李丹 陈晓燕 黄光伟 Roger RUAN | 2015 | 食品科学2015，36，2： | 39 |
| 9 | Changes of plasma D(-) -lactate, diamine oxidase and endotoxin in patients with liver cirrhosis显示文摘BACKGROUND: Plasma D(-)-lactate and diamine oxidase (DAO) can reflect patients’ intestinal mucosal condition. We evaluated the changes of plasma D (-)-lactate, DAO and endotoxin activities and their significance in patients with liver cirrhosis. METHODS: Fifty liver cirrhosis patients were enrolled into experimental group and 30 healthy people into control group. The plasma levels of D(-)-lactate, DAO and endo- toxin were detected spectrophotographically. RESULTS: The level of D(-)-lactate was significantly high- er in the experimental group than that in the control group (P<0.01). Significant differences of D (-)-lactate levels were observed in Child-Pugh subgroups of the experimen- tal group (P <0. 01). The level of DAO was significantly higher in the experimental group than that in the control group (P <0.01), but the level of DAO in Child-Pugh sub- group C was significantly lower than that in Child-Pugh subgroup B (P<0.01). The level of endotoxin was signifi- cantly increased in the experimental group except Child Pugh subgroup A (P<0.01). The plasma levels of D(-) lactate, DAO and endotoxin were positively correlated with each other (P<0.01). CONCLUSIONS: The data suggest that both plasma D(-) lactate and DAO activity are sensitive markers for early diagnosis of gut failure and endotoxemia in patients with liver cirrhosis. The impairment of intestinal barrier func- tion may be one of the critical reasons for deterioration of liver cirrhosis. | Peng Ruan, Zuo-Jiong Gong and Quan-Rong Zhang Wuhan, China Department of Infectious Diseases, Renmin Hospital Wuhan University Medical College, Wuhan 430060 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 31 |
| 10 | Rational groundwater table indicated by the ecophysiological parameters of the vegetation:A case study of ecological restoration in the lower reaches of the Tarim River显示文摘Populus euphratica Oliv 和 Tamarix ramosissima Ldb 的 eco 生理的反应和改编在水版本时期期间被调查。九个典型区域和 45 横断沿着 Tarim 河的更低的活动范围被选择。地下水桌子以及植物表演和脯氨酸,可溶的糖,和植物的内容内长的荷尔蒙(骆驼毛的织物, CTK ) 在叶子被监视并且分析。地下水桌子在不同区域被提起,横断走水路推出程序。生理的压力到 P。euphratica 和 T。ramosissima 在水版本以后被减少了。我们的结果建议在学习区域的地下水桌子在 3.15~4.12 m 留下了,从 9.28~11.06 的脯氨酸内容( mmol/L ),从 224.71~252.16 的可溶的糖内容( mmol/L ),从 3.59~5.01 的 ABA 内容( ng/g FW ),并且从 4.01~4.56 的 CK 内容( ng/g FW ),为最佳生长和 P 的恢复。植物性能参数和水申请的效率显示的 euphratica 最高。在学习区域的地下水桌子在 2.16~3.38 m 留下了,从 12.15~14.17 的脯氨酸内容( mmol/L ),从 154.71~183.16 的可溶的糖内容( mmol/L ),从 2.78~4.86 的 ABA 内容( ng/g FW ),并且从 3.78~4.22 的 CK 内容( ng/g FW ),为最佳生长和 T 的恢复。植物表演参数和水申请的效率显示的 ramosissima 最高。为在学习区域的植被的恢复的合理地下水桌子在 3.15 ~ 3.38 m。 | CHEN Yaning WANG Qiang LI Weihong RUAN Xiao CHEN Yapengr ZHANG Lihua | 2006 | Chinese Science Bulletin2006，51，A01： | 31 |
| 11 | 微射流均质机的流体动力学行为分析显示文摘本文将射流均质机振荡头内部孔道分成六个部分进料管区、分流管区、撞击管区、射流管区、扩流管区和出料管区,对其流场的动力学行为进行了分析,这为讨论射流均质机的超微粉碎的作用机制提供理论基础。 | 刘成梅 刘伟 高荫榆 Roger Ruan 林向阳 陈钢 | 2004 | 食品科学2004，25，4： | 32 |
| 12 | Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation显示文摘The causal agent for SARS is considered as a novel coronavirus that has never been described both in human and animals previously. The stability of SARS coronavirus in human specimens and in environments was studied. Methods Using a SARS coronavirus strain CoV-P9,which was isolated from pharyngeal swab of a probable SARS case in Beijing, its stability in mimic human specimens and in mimic environment including surfaces of commonly used materials or in household conditions, as well as its resistances to temperature and UV irradiation were analyzed. A total of 106 TCID50 viruses were placed in each tested condition, and changes of the viral infectivity in samples after treatments were measured by evaluating cytopathic effect (CPE) in cell line Vero-E6 at 48 h after infectionn. Results The results showed that SARS coronavirus in the testing condition could survive in serum, 1:20 diluted sputum and feces for at least 96 h, whereas it could remain alive in urine for at least 72 h with a low level of infectivity. The survival abilities on the surfaces of eight different materials and in water were quite comparable, revealing reduction of infectivity after 72 to 96 h exposure. Viruses stayed stable at 4℃, at room temperature (20℃) and at 37℃ for at least 2 h without remarkable change in the infectious ability in cells, but were convened to be non-infectious after 90-, 60- and 30-min exposure at 56℃, at 67℃ and at 75℃, respectively. Irradiation of UV for 60 min on the virus in culture medium resulted in the destruction of viral infectivity at an undetectable level. Conclusion The survival ability of SARS coronavirus in human specimens and in environments seems to be relatively strong. Heating and UV irradiation can efficiently eliminate the viral infectivity. | SHU-MING DUAN, XIN-SHENG ZHAO, RUI-FU WEN, JING-JING HUANG, GUO-HUA PI, SU-XIANG ZHANG, JUN HAN, SHENG-LI BI, LI RUAN, XIAO-PING DONGAND SARS RESEARCH TEAMInstitute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Ying-Xin Rd. 100, Beijing 100052, China | 2003 | Biomedical and Environmental Sciences2003，16，3： | 29 |
| 13 | Astragaloside IV ameliorates neuroinflammation- induced depressive-like behaviors in mice via the PPARY/NF-κB/NLRP3 inflammasome axis显示文摘 | Mei-ting SONG Jie RUAN Ru-yi ZHANG Jie DENG Zhan-qiang MA Shi-ping MA | 2018 | Acta Pharmacologica Sinica2018，39，10： | 28 |
| 14 | Microfluidizer对膳食纤维溶液物理性质的影响显示文摘本文研究了Microfludizer这种微射流均质机处理膳食纤维溶液产生的一些物理性质(如粘度、光学性、固形物含量等)的影响,结果显示:经Microfludizer破碎后的物料体系出现粘度略有提高、吸光度升高、透射比下降、折光率变化较小、总固形物含量下降等现象。 | 刘成梅 刘伟 林向阳 Roger Ruan | 2004 | 食品科学2004，25，2： | 27 |
| 15 | 一种基于FCM和LevelSet的MRI医学图像分割方法显示文摘对基于区域的几何活动轮廓模型中的区域项进行了改进.改进后的算法不仅解决了原算法存在的稳定性问题,同时也有效地提高了分割速度.算法还被成功地扩展到能够分割多种脑组织,且分割质量显著提高.多种子初始化方式的采用,进一步降低了算法对初始条件的敏感性,同时也减少了人工干预.对模拟和真实脑MRI图像的分割实验证明了改进的可行性和有效性,噪声条件下分割的比较分析也表明改进后的算法具有良好的韧性. | 陈志彬 邱天爽 SU Ruan | 2008 | 电子学报2008，36，9： | 26 |
| 16 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 17 | Microfluidizer对膳食纤维微粒粒度分布的影响显示文摘采用Nicomp380粒度分析仪,对应用Microfluidics公司生产的微射流均质机处理前后的膳食纤维溶液中微粒粒度分布的影响进行分析,结果显示:破碎后的微粒体系出现再团聚现象;不同压力,不同次数等条件处理下微粒粒度分布存在显著差异。 | 刘成梅 刘伟 林向阳 Roger Ruan | 2004 | 食品科学2004，25，1： | 26 |
| 18 | 中国需要构建怎样的周边显示文摘中国需要经略和平发展的周边,周边同样需要和平繁荣的中国。当前中国周边环境正经历新的大变革,西太平洋地区出现以中国和美国为核心的双中心格局,矛盾增多。中国周边外交着眼于为实现中华民族伟大复兴的中国梦,塑造友善的国际环境,具体路径是:大国当先,良性互动;一带一路,大鹏展翅;完善体制,提升效率;排除干扰,坚持走和平发展道路。 | Ruan Zongze | 2014 | 国际问题研究2014，，2： | 24 |
| 19 | Energy-Efficient Multi-UAV Coverage Deployment in UAV Networks:A Game-Theoretic Framework显示文摘UAV cooperative control has been applied in many complex UAV communication networks. It remains challenging to develop UAV cooperative coverage and UAV energy-efficient communication technology. In this paper, we investigate current works about UAV coverage problem and propose a multi-UAV coverage model based on energy-efficient communication. The proposed model is decomposed into two steps: coverage maximization and power control, both are proved to be exact potential games(EPG) and have Nash equilibrium(NE) points. Then the multi-UAV energy-efficient coverage deployment algorithm based on spatial adaptive play(MUECD-SAP) is adopted to perform coverage maximization and power control, which guarantees optimal energy-efficient coverage deployment. Finally, simulation results show the effectiveness of our proposed approach, and confirm the reliability of proposed model. | Lang Ruan Jinlong Wang Jin Chen Yitao Xu Yang Yang Han Jiang Yuli Zhang Yuhua Xu | 2018 | China Communications2018，15，10： | 24 |
| 20 | Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma显示文摘AIM: To evaluate the efficacy and safety of gemcitabine-oxaliplatin (GEMOX) combined with huachansu (cinobufagin) injection treatment in patients with locally advanced or metastatic gallbladder carcinoma (GBC), and to assess the quality of life (QOL) of such patients. METHODS: Twenty-fi ve patients with locally advanced or metastatic GBC were treated with intravenous gemcitabine (1000 mg/m2) over 30 min on days 1 and 8, 2 h infusion of oxaliplatin (120 mg/m2) on day 1, and 2-3 h infusion of huachansu (20 mL/m2) on days -3-11, every 3-4 wk. Treatment was continued until occurrence of unacceptable toxicity or disease progression. QOL of patients was assessed by the EORTC QLQ-C30 at baseline, at the end of the fi rst, third and sixth chemotherapy cycles, and 1 mo after the treatment. RESULTS: Among the 25 patients with a median age of 64 years (range 42-78 years), 23 were evaluable in the study. A total of 137 cycles of therapy were performed and the median cycle was 5 (range 1-8) per patient. Out of the 23 patients whose response couldbe evaluated, 8 partial responses (PR) were observed (34.8%), while 7 patients (30.4%) demonstrated a stable disease (SD). The disease control rate was 65.2%. Progression of cancer was observed in 8 (34.8%) patients. The median progression-free and overall survival time was 5.8 mo (95% CI: 4.5-7.1 mo) and 10.5 mo, respectively. The therapy was well tolerated, with moderate myelosuppression as the main toxicity. Anemia grade 2 was seen in 16.0%, neutropenia grade 3 in 8.0% and thrombocytopenia grade 3 in 24.0% of patients, respectively. Non-hematologic toxicity ranged from mild to moderate. No death occurred due to toxicity. The QOL of patients was improved after chemotherapy, and the scores of QOL were increased by 10 to 20 points. CONCLUSION: GEMOX combined with huachansu (cinobufagin) injection is well tolerated, effective, thus improving the QOL of patients with advanced GBC. | Tian-Jie Qin Xin-Han Zhao Jun Yun Ling-Xiao Zhang Zhi-Ping Ruan Bo-Rong Pan | 2008 | World Journal of Gastroenterology2008，14，33： | 22 |
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