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| 1 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 2 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 3 | Short-pulse laser-plasma interactions显示文摘 | Gibbon P Frster E | 1996 | Plasma Physics and Controlled Fusion1996，38，： | 2 |
| 4 | Acellular Muscle with Schwann-Cell Implantation: An Alternative Biologic Nerve Conduit显示文摘 | Hisham Fansa Gerburg Keilhoff Gerhard F?rster Bertolt Seidel Gerald Wolf Wolfgang Schneider | 1999 | J reconstr Microsurg1999，，07： | 2 |
| 5 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death显示文摘 | Alexander Seiler Manuela Schneider Heidi F?rster Stephan Roth Eva K. Wirth Carsten Culmsee Nikolaus Plesnila Elisabeth Kremmer Olof R?dmark Wolfgang Wurst Georg W. Bornkamm Ulrich Schweizer Marcus Conrad | 2008 | Cell Metabolism2008，，3： | 2 |
| 6 | 电极粘结剂沥青——生产阳极的一种主要原料,原料、生产、应用及运输方面的发展趋势显示文摘煤沥青本身的化学结构使其特别适合作为生产阳极的粘结剂。概述了在原料、煤焦油到粘结剂沥青的加工及新的运输系统等方面的最新发展趋势。新制定的分析和试验方法和先进的处理工艺相结合,提高了粘结剂沥青的质量以满足铝生产对阳极越来越苛刻的要求。 | A.Alscher R.Wildfrster 时雨 | 1990 | 炭素技术1990，9，5： | 2 |
| 7 | 弯晶X射线光学(英文)显示文摘近年来,人们付出很大精力研制新的具有独特性能的同步辐射装置和自由电子激光器,而飞秒激光等离子源可提供具有高峰值亮度的超短X射线脉冲,用来作为波荡器辐射的补充X射线源。此外,所有最新型的X射线源的诊断和应用也都需要专用X射线光学元件或仪器。X射线光谱测量是激光聚变应用中最重要的等离子诊断方法之一,该方法根据实验目的,可获得单色X射线图像或与空间或时间分辨相组合的高分辨率图像。已经研制出拥有多达10个环状弯晶的高精单色成像仪,用以研究激光聚变实验中的内爆过程并通过获得的数据对等离子体参数的时间分辨图做出评估。大功率飞秒激光器可提供实用的相对价格不高的大功率X射线脉冲源,但需要有发光效率,能量分布,以及热电子传输方面的信息来实现理想K层辐射线或者连续X射线输出的最大化,以便得到相当于同步辐射输出的峰值亮度。把这些新的射线源与弯晶光学元件相组合,可完成亚皮秒时间量级的衍射实验。激光泵浦的X射线探针实验已经展示了若干晶体在250 fs内的结构变化。作者所在研究所使用光线追踪和布拉格反射方法设计了1D或2D或1D与2D结合的弯晶X射线光学仪器。在仪器制备过程中,非常注重晶体完整,反射选择的优化,弯曲精确,以及成像和反射特性的测量,还使用X射线形貌相机和衍射仪对分析器晶体的相关特性做了测试。 | E Frster | 2007 | 光学精密工程2007，15，12： | 2 |
| 8 | Principles for characterizing the potential human health effects from exposure to nanomaterials:elements of a screening strategy显示文摘 | Oberdrster G Maynard A Donaldson K | 2005 | Part Fibre Toxicol2005，2，： | 1 |
| 9 | Limitations of the motivational intensity model of attentional tuning:reply to HarmonJones,Gable,and Price显示文摘 | Friedman R.S F(o)rster J | | 0，，： | 1 |
| 10 | Including RNA secondary structures improves accuracy and robustness in reconstruction of phylogenetic trees显示文摘 | Keller A F?rster F Müller T | 2010 | Biol Direct2010，5，4： | 1 |
| 11 | Tight junctions and the modulation of barrier function in disease显示文摘 | Carola F rster | 2008 | Histochem Cell Biol2008，130，： | 1 |
| 12 | MR imaging-guided intravenous thrombolysis in posterior cerebral artery stroke显示文摘 | F(o)rster A Gass A Kern R | | 0，，02： | 1 |
| 13 | The effects of promotion and prevention cues on creativity显示文摘 | Friedman R.S Rster J.F | | 0，，06： | 1 |
| 14 | Long-term pyrene exposure of grass shrimp,Palaemonetes pugio,affects molting and reproduction of exposed males and off-spring of exposed females显示文摘 | Oberd rster E Brouwer M Hoexum-Brouwer T | 2000 | Environ Health Perspect2000，108，7： | 1 |
| 15 | Acel ular muscle with Schwann-cel implantation:an alternative biologic nerve conduit显示文摘 | Fansa H Keilhoff G F?rster G | | 0，，07： | 1 |
| 16 | Nanotoxicology:an emerging discipline evolving from studies of ultrafine particles显示文摘 | Oberdrster G Oberdrster E Oberdrster J | 2005 | Environmental Health Perspectives2005，113，7： | 1 |
| 17 | Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats显示文摘 | Oberdrster G Sharp Z Atudorei V | 2002 | J Toxicol Environ Health2002，65，20： | 1 |
| 18 | CCR9 and inflammatory bowel disease显示文摘 | Koenecke C F(o)rster R | | 0，，3： | 1 |
| 19 | Ectopic expression of CCL19 impairs alloimmune response in mice显示文摘 | Krautwald S Ziegler E F(o)rster R | 2004 | Immunology2004，112，： | 1 |
| 20 | 查看详情显示文摘 | Antonietti M F(o)rster S | | 0，，： | 1 |
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