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| 1 | Liver injury induced by paracetamol and challenges associated with intentional and unintentional use显示文摘Drug induced liver injury(DILI)is a common cause of acute liver injury.Paracetamol,also known as acetaminophen,is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic levels.Hepatotoxicity from paracetamol overdose,whether intentional or nonintentional,is the most common cause of DILI in the United States and remains a global issue.Given the increased prevalence of combination medications in the form of pain relievers and antihistamines,paracetamol can be difficult to identify and remains a significant cause of acute hepatotoxicity,as evidenced by its contribution to over half of all acute liver failure cases in the United States.This is especially concerning given that,when co-ingested with other medications,the rise in serum paracetamol levels may be delayed past the 4-hour post-ingestion mark that is currently used to determine patients that require medical therapy.This review serves to describe the clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol and provide an update on current available knowledge and treatment options. | Laura Rotundo Nikolaos Pyrsopoulos | 2020 | World Journal of Hepatology2020，12，4： | 4 |
| 2 | Increased muscle PGC - 1 alpha expression protects from sar- copenia and metabolic disease during aging 显示文摘 | Wenz T Rossi S G Rotundo R L | 2009 | Natl Acad Sci USA2009，106，20： | 1 |
| 3 | Endoscopic carbon dioxide laser surgery for glottic cancer recurrence after radiotherapy : oncological results 显示文摘 | Ansarin M Planicka M Rotundo S | 2007 | Arch Otolaryngol Head Neck Surg2007，133，12： | 1 |
| 4 | Litter effects on plant regenera- tion in arid lands: a complex balance between seed retention, seed longevity and soil-seed contact 显示文摘 | ROTUNDO J L AGUIAR M R | 2005 | Journal of Ecology2005，93，4： | 1 |
| 5 | Understanding the domain of eounterproducliw~ work behavior in China 显示文摘 | Rotundo M Xie J L | 2008 | Inter- national Journal of Human Resource Management2008，19，5： | 1 |
| 6 | Lack of adjunctive benefit of Er:YAG laser in non-surgical periodontal treatment:a randomized split-mouth clinical trial 显示文摘 | Rotundo R Nieri M Cairo F | 2010 | J Clin Periodontol2010，37，6： | 1 |
| 7 | Unemployed Individuals: Motives, Job Search, Competencies, and Job Search Constraints as Predictors of Job Seeking and Reemployment显示文摘 | WANBERG C R KANFER R ROTUNDO M | 1999 | Journal of Applied Psychology1999，84，6： | 1 |
| 8 | The Relative Importance of Task,Citizenship, and Counterproductive Performance to Global Ratings of Job Performance : A Policy - capturing Approach 显示文摘 | Rotundo M Sackett P R | 2002 | Journal of Applied Psychology2002，87，3： | 1 |
| 9 | The Relative Importance of Task, Citizenship, and Counterproductive Performance to Global Ratings of Job Performance: A Policy - capturing Approach 显示文摘 | Rotundo M Sackett P R | 2002 | Journal of Applied Psychology2002，87，1： | 1 |
| 10 | Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging显示文摘 | Wenz T Rossi S Rotundo RL | | 0，，： | 1 |
| 11 | American Fatherhood:A Historical Perspective显示文摘 | Rotundo EA | 1985 | American Behavioral Scientist1985，29，1： | 1 |
| 12 | Unemployed individuals: Motives, job-search competencies, and job-search constraints as predictors of job seeking and reemployment显示文摘 | Wanberg C R Kanfer R Rotundo M | 1999 | Journal of Applied Psychology1999，84，6： | 1 |
| 13 | Factors affecting the clinical approach to impacted maxillary canines:A Bayesian networkanalys- is 显示文摘 | Nieri M Crescini A Rotundo R | 2010 | Am J Orthod Dentofacial Orthop2010，137，6： | 1 |
| 14 | Dissimilar linearfriction welding betweena SiC particle reinforced aluminumcomposite and a monolithic aluminum alloy : Microstructur-al,tensile and fatigue properties 显示文摘 | Rotundo F Marconi A Morri A | 2013 | Materials Science &Engineering A2013，55，985： | 1 |
| 15 | Absence of acetylcholinesterase at the neuromuscular junctions of perlecan null mice显示文摘 | Arikawa-Hirasawa E Rossi SG Rotundo RL | 2002 | Nat Neurosci2002，5，： | 1 |
| 16 | The relativeimportance of task,citizenship,and counterpro-ductive performance to global ratings of job per-formance :a policy capturing approach 显示文摘 | Rotundo M Sackett PR | 2002 | Jour-nal of Applied Psychology2002，87，： | 1 |
| 17 | Aesthetic perception after root coverage procedure显示文摘 | Rotundo R Nieri M Mori M | 2008 | J Clin Periodontol2008，35，8： | 1 |
| 18 | Understanding the Domain of Counterproductive Work Behavior in China 显示文摘 | Rotundo M Xie J L | 2008 | The International Journal of Human Resource Management2008，19，5： | 1 |
| 19 | Periodontic-endodontic lesions:diagnostic and therapeutic indications显示文摘 | Muzzi L Rotundo R Cairo F | 2002 | Minerva Stomato12002，51，12： | 1 |
| 20 | Absence of acetylcholinesterase at the neuromuscularJunctions of perlecan- null mice显示文摘 | Arikawa-Hirasawa E Rossi SG Rotundo RL | 2002 | Nat Neurosci2002，5，2： | 1 |
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