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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Glutanate transporter protein subtypes are expressed differentially during rat CNS development显示文摘 | Furuta A Rothstein J D Martin L J | 1997 | J Neurosci1997，17，： | 1 |
| 3 | Initial recovery of soil carbon and nitrogen pools and dynamics following disturbance in jack pine forests:A comparison of wildfire and eleareut harvesting显示文摘 | Stephen D L Rothstein D E | 2007 | Soil Biology & Biochemistry2007，39，： | 1 |
| 4 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 5 | Localization of neuronal and glial glutamate transporters显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neuron1994，13，3： | 1 |
| 6 | Kinetics of nitrogen uptake by Populus tremuloides in relation to atmospheric CO2 and soil nitrogen availability显示文摘 | Rothstein D E Zak D R Pregitzer K S Curtis P S | 2000 | Tree Physiology2000，20，4： | 1 |
| 7 | Effects of nitrogen form on nutrient uptake and physiology of Fraser fir (Abies fraseri) 显示文摘 | Rothstein D E Cregg B M | 2005 | Forest ecology and management2005，219，1： | 1 |
| 8 | Transformation of a partial nopaline synthase gene into tobaccosuppresses the expression of a resident wild-type gene显示文摘 | Goring D R Thomson L Rothstein S J | 1991 | Proc Natl Aad Sci USA1991，88，： | 1 |
| 9 | Knockout of glutamate transporters reveals a major role for astroglial transportin excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996，16，3： | 1 |
| 10 | Relationships between plant nitrogen economy and life history in three deciduous-forest herbs显示文摘 | ROTHSTEIN D E ZAK D R | 2001 | Journal of Ecology2001，89，3： | 1 |
| 11 | The use of personality measures in personnel selection:What does current research support显示文摘 | MitchellG .Rothstein Richard D .Goffin | | 0，，： | 1 |
| 12 | Spring ephemeral herbs and nitrogen cycling in a northern hardwood forest:an experimental test of the vernal dam hypothesis 显示文摘 | Rothstein D E | 2000 | Oecologia2000，124，： | 1 |
| 13 | Effects of nitrogen form on nutrient uptake and physiology of Fraser fir (Abies fraseri ) 显示文摘 | ROTHSTEIN D E CREGG B M | 2005 | Forest Ecology and Management2005，219，： | 1 |
| 14 | Solubility behavior of Ca-, S-, Al-, and Si-bearing solid phases in Portland cement pore solutions as a function of hydration time显示文摘 | ROTHSTEIN D THOMAS J J CHRISTENSEN B J | 2002 | Cern Concr Res2002，32，10： | 1 |
| 15 | Sam2, the second methionine S-adenosyl Tansferase in Sopcharomyces cerevisiae physiology and regulation of both enzymes显示文摘 | THOMAS D ROTHSTEIN R ROSENBERG N | 1988 | Mol Cell Biol1988，8，： | 1 |
| 16 | Quantifying threats to imperiled species in the United States显示文摘 | WILCOVE D S ROTHSTEIN D DUBOW J | 1998 | Bio Science1998，48，8： | 1 |
| 17 | Endoscopic full-thickness plication for the treatment of GERD:12-months follow-up for the North American open-label trial显示文摘 | Pleskow D Rothstein R Lo S | 2005 | Gasrointest Endosc2005，61，6： | 1 |
| 18 | Photosynthetic adaptation and acclimation to exploit seasonal periods of direct irradiance in three temperate,deciduous-forest herbs显示文摘 | Rothstein D E Zak D R | | 0，，06： | 1 |
| 19 | Quantifying threats to imperiled species in the United States显示文摘 | WILCOVE D S ROTHSTEIN D DUBOW J | 1998 | Bioscience1998，48，： | 1 |
| 20 | Kuncl RW: localization of neuronal and glial glutamate transporter 显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neurons1994，13，： | 1 |
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