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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Glutanate transporter protein subtypes are expressed differentially during rat CNS development显示文摘 | Furuta A Rothstein J D Martin L J | 1997 | J Neurosci1997，17，： | 1 |
| 3 | Interannual and decadal variability of the subsurface thermal structure in the Pacific Ocean: 1961-1990 显示文摘 | ZHANG R H ROTHSTEIN L M BASALACCHI A J | 1999 | Climate Dynamic1999，15，： | 1 |
| 4 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 5 | Localization of neuronal and glial glutamate transporters显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neuron1994，13，3： | 1 |
| 6 | Efficacy of a novel rifamycin derivative,ABI-0043,against Staphylococcus aureus in an experimental model of foreign-body infection显示文摘 | Trampuz A Murphy CK Rothstein DM | 2007 | Antimicrob Agents Chemother2007，51，7： | 1 |
| 7 | Sex bias or equal opportunity ? Patterns of maternal investment in bison 显示文摘 | Green W C H Rothstein A | 1991 | Behav Ecol Sociobiol1991，29，： | 1 |
| 8 | Knockout of glutamate transporters reveals a major role for astroglial transportin excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996，16，3： | 1 |
| 9 | Kuncl RW: localization of neuronal and glial glutamate transporter 显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neurons1994，13，： | 1 |
| 10 | Food hoarding by merriams kangaroo rats: a test of alternative hypotheses 显示文摘 | Jenkins S H Rothstein A Green W C | 1995 | Ecology1995，76，： | 1 |
| 11 | Regulation of the accumulation and reduction of nitrate by nitrogen and carbon metabolites in maize seedlings显示文摘 | Sivasankar S Rothstein S Oaks A | 1997 | Plant Physiol1997，114，： | 1 |
| 12 | Regulation of the accumulation and reduction of nitrate by nitrogen and carbon metabolites in maize seedlings 显示文摘 | Sivasankar S Rothstein S Oaks A | 1997 | Plant Physiology1997，114，2： | 1 |
| 13 | The development of dysplasia and adenocarcinoma during endoscopic surveillance of Barrett's esophague 显示文摘 | Katz D Rothstein R Lindgren A | 1998 | Am J Gartroenterol1998，93，4： | 1 |
| 14 | Cyclic regulation of CD45 isoform expression in a long term human CD4^+CD45RA^+T cell line显示文摘 | Rothstein DM Yama A Schlossman SF | 1991 | Immunology1991，146，4： | 1 |
| 15 | Geothermal gradients in continental magmatic arcs: Constraints from the eastern Peninsular Ranges batholith, Baja California, Mexico显示文摘 | Rothstein D A Manning C E | 2003 | Geological Society of America2003，374，： | 1 |
| 16 | The Failure of Anti- Corruption Policies: A Theoretical Mischaracterization of the Problem 显示文摘 | Persson A Rothstein B Teorell J | 2010 | Qualiby of Government Institute Working Paper Series2010，，19： | 1 |
| 17 | Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease显示文摘 | Marshak Rothstein A Rifkin I R | 2007 | Annu Rev Immunol2007，25，： | 1 |
| 18 | Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996，16，3： | 1 |
| 19 | Bone morpho- genetic proteins promote gliosis in demyelinating spinal cord le- sions显示文摘 | Fuller M L DeChant A K Rothstein B | 2007 | Ann Neurol2007，62，3： | 1 |
| 20 | The transport of Znz+ ,Co^2+ and Ni^2+ into yeast cells显示文摘 | Fuhrmann G F Rothstein A | 1968 | Biochim Biophys Acta1968，163，： | 1 |
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