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| 1 | Brain edema and intracranial hypertension in fulminant hepatic failure:Pathophysiology and management显示文摘Intracranial hypertension is a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure. The etiology of this intracranial hypertension is not fully determined, and is probably multifactorial, combining a cytotoxic brain edema due to the astrocytic accumulation of glutamine, and an increase in cerebral blood volume and cerebral blood flow, in part due to inflammation, to glutamine and to toxic products of the diseased liver. Validated methods to control intracranial hypertension in fulminant hepatic failure patients mainly include mannitol, hypertonic saline, indomethacin, thiopental, and hyperventilation. However all these measures are often not sufficient in absence of liver transplantation, the only curative treatment of intracranial hypertension in fulminant hepatic failure to date. Induced moderate hypothermia seems very promising in this setting, but has to be validated by a controlled, randomized study. Artificial liver support systems have been under investigation for many decades. The bioartificial liver, based on both detoxification and swine liver cells, has shown some efficacy on reduction of intracranial pressure but did not show survival benefit in a controlled, randomized study. The Molecular Adsorbents Recirculating System has shown some efficacy in decreasing intracranial pressure in an animal model of liver failure, but has still to be evaluated in a phase Ⅲ trial. | Olivier Detry Arnaud De Roover Pierre Honoré Michel Meurisse | 2006 | World Journal of Gastroenterology2006，12，46： | 12 |
| 2 | Carcinoid tumor of the appendix: A consecutive series from 1237 appendectomies显示文摘AIM: To report the experience of the CHU Sart Tilman, University of Liège, Belgium, in the management of appendiceal carinoid tumor. METHODS: A retrospective review of 1237 appendecto- mies performed in one single centre from January 2000 to May 2004, was undertaken. Analysis of demographic data, clinical presentation, histopathology, operative re- ports and outcome was presented. RESULTS: Among the 1237 appendectomies, 5 appen- diceal carcinoid tumors were identified (0.4%) in 4 male and 1 female patients, with a mean age of 29.2 years (range: 6-82 years). Acute appendicitis was the clinical presentation for all patients. Four patients underwent open appendectomy and one a laparoscopic procedure. One patient was reoperated to complete the excision of mesoappendix. All tumors were located at the tip of the appendix with a mean diameter of 0.6 cm (range: 0.3-1.0 cm). No adjuvant therapy was performed. All patients were alive and disease-free during a mean follow-up of 33 mo. CONCLUSION: Appendiceal carcinoid tumor most of- ten presents as appendicitis. In most cases, it is found incidentally during appendectomies and its diagnosis is rarely suspected before histological examination. Appen- diceal carcinoid tumor can be managed by simple appen- dectomy and resection of the mesoappendix, if its size is ≤ 1 cm. | Vincent Tchana-Sato Olivier Detry Marc Polus Albert Thiry Bernard Detroz Sylvie Maweja Etienne Hamoir Thierry Defechereux Carla Coimbra Arnaud De Roover Michel Meurisse Pierre Honoré | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 3 | Donation after cardio-circulatory death liver transplantation显示文摘The renewed interest in donation after cardio-circulatory death (DCD) started in the 1990s following the limited success of the transplant community to expand the donation after brain-death (DBD) organ supply and following the request of potential DCD families. Since then, DCD organ procurement and transplantation activities have rapidly expanded, particularly for nonvital organs, like kidneys. In liver transplantation (LT), DCD donors are a valuable organ source that helps to decrease the mortality rate on the waiting lists and to increase the availability of organs for transplantation despite a higher risk of early graft dysfunction, more frequent vascular and ischemia-type biliary lesions, higher rates of re-listing and re-transplantation and lower graft survival, which are obviously due to theinevitable warm ischemia occurring during the declaration of death and organ retrieval process. Experimental strategies intervening in both donors and recipients at different phases of the transplantation process have focused on the attenuation of ischemia-reperfusion injury and already gained encouraging results, and some of them have found their way from pre-clinical success into clinical reality. The future of DCD-LT is promising. Concerted efforts should concentrate on the identification of suitable donors (probably Maastricht category Ⅲ DCD donors), better donor and recipient matching (high risk donors to low risk recipients), use of advanced organ preservation techniques (oxygenated hypothermic machine perfusion, normothermic machine perfusion, venous systemic oxygen persufflation), and pharmacological modulation (probably a multi-factorial biologic modulation strategy) so that DCD liver allografts could be safely utilized and attain equivalent results as DBD-LT. | Hieu Le Dinh Arnaud de Roover Abdour Kaba Séverine Lauwick Jean Joris Jean Delwaide Pierre Honoré Michel Meurisse Olivier Detry | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 4 | Regular star polymers with 64 and 128 arms - models for polymeric micelles显示文摘 | ROOVERS J ZHOU L L TOPOROWSKI P M | 2003 | Macromolecules2003，26，16： | 1 |
| 5 | An interference-robust receiver for ultra-wideband radio in SiGe BiCMOS technology显示文摘 | Leenaerts D M W Bergevoet J | 2005 | IEEE J Solid-State Circuits2005，40，12： | 1 |
| 6 | Embryo produc- tion by ovum pikc-up in unstimulated calves before and after puberty显示文摘 | Majerus V De Roover R Etienne D | 1999 | Theriogenology1999，52，7： | 1 |
| 7 | Effect of nitrogen concentration on fructan metabolizing enzymes in young chicory plants (Cichorium intybus)显示文摘 | Van den Ende W Roover J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 8 | Hysterectomy and sexual wellbeing:prospective observational study of vaginal hysterectomy,subtotal abdominal hysterectomy,and total abdominal hysterectomy显示文摘 | Roovers JP van der Bom JG van der Vaart CH | 2003 | BMJ2003，327，7418： | 1 |
| 9 | Effect of nitrogen concen-tration on fructan metabolizing enzymes in young chicory plants(Cichorium intybus) 显示文摘 | Ende V D Roover W J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 10 | Bariatric surgery in patients with type 2 diabetes:benefits,risks,indications and perspectives显示文摘 | Scheen AJ De Flines J De Roover A | 2009 | Diabetes Metab2009，35，62： | 1 |
| 11 | Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR nanobodies显示文摘 | Roovers RC Laeremans T Huang L | 2007 | Cancer Immunol Immunother2007，56，： | 1 |
| 12 | Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies 显示文摘 | Roovers RC Laeremans T Huang Lieven | 2007 | Cancer Immunol Immunother2007，56，3： | 1 |
| 13 | Liver Transplantation Using Non-Heart-Beating Donors: Belgian Experience显示文摘 | D. Monbaliu F. Van Gelder R. Troisi B. de Hemptinne J. Lerut R. Reding J. de Ville de Goyet O. Detry A. De Roover P. Honore V. Donckier M. Gelin D. Ysebaert R. Aerts W. Coosemans J. Pirenne | 2007 | Transplantation Proceedings2007，，5： | 1 |
| 14 | Molecular characterization of maleic anhydride2functionalized polypropylene显示文摘 | De Roover B Sclavons M Carlier V | 1995 | J Polyrn Sci(part A)1995，33，5： | 1 |
| 15 | Idarubicin to intensify the conditioning regimens of autologous bone marrow transplantation for patients with acute myeloid leukemia in first complete remission 显示文摘 | Jerjis S Roovers E Muus P | 1998 | Bone Marrow Transplant1998，22，1： | 1 |
| 16 | Bariatric surgery in patients with Type 2 diabetes:benefits,risks,indications and perspectives显示文摘 | Scheen AJ De Flines J De Roover A | 2009 | Diabetes Metab2009，35，： | 1 |
| 17 | E{{ect of nitrogen concentration on i'ructan metabolizing enzymes in young chic- ory plants (Cichorium intybus )显示文摘 | Van den Ende W Roover J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 18 | Ouvm pick up and in vitro embyo production in cows superstimulated with an individually adapted supers- timulation protocol显示文摘 | ROOVER D GENICOT G LEONARD S | 2005 | Anita Repord Sci2005，86，12： | 1 |
| 19 | 显示文摘 | Todorovaka A Roovers RC Dolezal O | 2001 | J Immunol Methods2001，248，12： | 1 |
| 20 | Surgical management of uri- nary stress incontinence in women: a historical and clinical overview 显示文摘 | Hinoul P Roovers J P Ombelet W | 2009 | Eur J Obstet Gynecol Reprod Biol2009，145，2： | 1 |
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