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| 1 | Single Mutations in the Transmembrane Domains of Maize Plasma Membrane Aquaporins Affect the Activity of Monomers within a Heterotetramer显示文摘Aquaporins 是越过生物的膜便于水或小无电荷的溶质的散开的隧道。他们作为 homotetramers 集合,但是他们中的一些也形成 heterotetramers,特别在植物。在 Zea mays,属于血浆膜的 aquaporins 当在 Xenopus 卵母细胞表示了时,内在的蛋白质(果仁) 亚科被聚类进二个组, PIP1 和 PIP2,它展出不同水隧道活动。当 PIP1 和 PIP2 isoforms 被共同表示时,他们身体上交往调制他们的 subcellular 本地化和隧道活动。这里,我们由亲密关系层析纯化证明当在 Xenopus 卵母细胞共同表示时,玉米 PIP1; 2 并且 PIP2; 5 isoforms 作为人集合 -- 并且在 heterotetramers 以内的 heterodimers。我们由根据菠菜 SoPIP2 的比较建模造了如此的 heterotetramers 的 3D 结构;在通常认为地在在单体之间的接口交往的 transmembrane 域的 1 X 光检查结构和识别氨基酸残余。他们在水隧道活动, subcellular 本地化,蛋白质丰富,和物理相互作用的角色被 mutagenesis 调查。我们加亮也使 PIP2 失去活性的单个残余的替换; 5 或激活的 PIP1; 2 没有影响他们的相互作用。有趣地,在 transmembrane 领域的 Phe220Ala 变化 5 PIP1; 2 激活它的水隧道活动并且同时,使 PIP2 失去活性; 5 在 heterotetramer 以内。总的来说,这些数据在他们的水隧道活动贡献在果仁 isoforms 和 heterotetramerization 的角色之间的相互作用机制的更好的理解。 | Marie C. Berny Dimitri Gilis Marianne Rooman Francois Chaumont | 2016 | Molecular Plant2016，9，7： | 5 |
| 2 | Chronic pancreatitis: A path to pancreatic cancer显示文摘 | Andreia V. Pinho Lorraine Chantrill Ilse Rooman | 2014 | Cancer Letters2014，，2： | 3 |
| 3 | In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells显示文摘 | L. Baeyens S. Breuck J. Lardon J. K. Mfopou I. Rooman L. Bouwens | 2005 | Diabetologia2005，，1： | 3 |
| 4 | A nonmosaic 45,X karyotype in a mother with Turner's syndrome and in her daughter显示文摘 | COOLS M ROOMAN R P WAUTERS J | 2004 | Fertil Steril2004，82，4： | 1 |
| 5 | Why do security prices change? A transaction-level analysis of NYSE stock显示文摘 | Madhavan A Richardson M Roomans M | 1997 | Review of Financial Studies1997，10，： | 1 |
| 6 | p53-dependent regulation of growth,epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells显示文摘 | Pinho AV Rooman I Real FX | 2011 | Cell Cycle2011，10，8： | 1 |
| 7 | Early cardiac abnormalities in obese children: Importance of obesity per seversus associated cardiovascular risk factors 显示文摘 | van Putte - Katier N Rooman RP Haas L | 2008 | Pediatr Res2008，64，2： | 1 |
| 8 | Why do security prices change? A transaction-level analysis of NYSE stock 显示文摘 | Madhavan A Richardson M Roomans M | 1997 | Review of Financial Studies1997，10，： | 1 |
| 9 | Contribution of cation-π interactions to the stability of protein-DNA complexes显示文摘 | Wintjens R Lievin J Rooman M | 2000 | J Mot Biol2000，302，2： | 1 |
| 10 | Why Do Security Prices Change? -A Transaction Level Analysis of NYSE Stocks显示文摘 | MADHAVAN A RICHARDSON M ROOMANS M | 1997 | Review of Financial Studies1997，10，4： | 1 |
| 11 | Nestin expression in pancreatic stenate cells and angiogenic endothelial cells 显示文摘 | Lardon J Rooman I Bouwens L | 2002 | Histochem Cell Biol2002，117，6： | 1 |
| 12 | Regulation of pancreatic beta-cell mass显示文摘 | BOUWENS L ROOMAN I | 2005 | Physiol Rev2005，85，4： | 1 |
| 13 | Why do security prices change? a transaction-level analysis of NYSE stocks显示文摘 | Madhavan A Richardson M Roomans M | 1997 | Review of Financial Studies1997，10，4： | 1 |
| 14 | Impact of texture-enhanced transmission on high-efficiency surface-textured light-emitting diodes 显示文摘 | Rooman C Meinlschmidt S | 2001 | Appl Phys Lett2001，79，15： | 1 |
| 15 | IGF-I,IGF-II,'free'IGF-I and IGF-binding proteins-2to-6during high-dose oestrogen treatment in constitutionally tall girls显示文摘 | Rooman R P De Beeck L O Martin M | 2002 | Eur J Endocrinol2002，146，6： | 1 |
| 16 | The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma显示文摘 | Martinez-Romero C Rooman I Skoudy A | 2009 | J Pathol2009，219，2： | 1 |
| 17 | In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells显示文摘 | L. Baeyens S. Breuck J. Lardon J. K. Mfopou I. Rooman L. Bouwens | 2005 | Diabetologia2005，，1： | 1 |
| 18 | Why do security prices change? A transaction-level analysis of NYSE stocks 显示文摘 | Madhavan A Richardson M Roomans M | 1997 | Review of Financial Studies1997，10，4： | 1 |
| 19 | p53-dependent regulation of growth, epithelial mesenchymal transition and stemness in normal pancreatic epithelial cells 显示文摘 | Pinho AV Rooman I Real FX | 2011 | Cell Cycle2011，10，8： | 1 |
| 20 | Why do security prices change? A transaction-level analysis of NYSE Stocks显示文摘 | Madhavan A Richardson M Roomans M | 1997 | Review of Financial Studies1997，10，4： | 1 |
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