|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver显示文摘Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and function and in hepatic insulin action.Whereas mitochondria are important regulators of energy metabolism,the nutritional regulation of MAM in the liver and its role in the adaptation of mitochondria physiology to nutrient availability are unknown.In this study,we found that the fasted to postprandial transition reduced the number of endoplasmic reticulum-mitochondria contact points in mouse liver.Screening of potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of hepatic MAM integrity both in vitro and in vivo.Glucose reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria fission,and impaired respiration.Blocking MAM reduction counteracted glucose-induced mitochondrial alterations.Furthermore,disruption of MAM integrity mimicked effects of glucose on mitochondria dynamics and function.This glucose-sensing system is deficient in the liver of insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of MAM integrity,mitochondrial fission,and altered mitochondrial respiration.These data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of mitochondria dynamics and function during nutritional transition.Chronic disruption of MAM may participate in hepatic mitochondrial dysfunction associated with insulin resistance. | Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer Hubert Vidal Jennifer Rieusset | 2016 | Journal of Molecular Cell Biology2016，8，2： | 2 |
| 2 | Human colon carcinoma cell-line HCT116 transfected by antisense cDNA as a tool to study the Ku86 involvement in cell proliferation显示文摘 | SADJI Z ROMANCER M L LEWIN M J | 2000 | Cell Signal2000，12，1112： | 1 |
| 3 | A characterization of the MM*-position of a convex body in terms of covariance matrices显示文摘 | Bastero J Romance M | 2004 | Israel J Math2004，141，： | 1 |
| 4 | Methylation,a key step for nongenomic estrogen signaling in breast tumors显示文摘 | Le Romancer M Treilleux I Bouchekioua-Bouzaghou K | | 0，，： | 1 |
| 5 | Positions of convex bodies associated to extremal problems and isotropic measures显示文摘 | Bastero J Romance M | 2004 | Adv Math2004，184，： | 1 |
| 6 | Biological characterization of various geographical isolates of Potato virusY inducing superficial necrosis on potato tubers 显示文摘 | LE ROMANCER M KERLAN C NEDELLEC M | 1994 | Plant Pathol1994，43，1： | 1 |
| 7 | Methylation, a key step for nongenomic estrogen signaling in breast tumors显示文摘 | Le Romancer M Treilleux I Bouehekioua-Bouzaghou K | 2010 | Steroids2010，75，89： | 1 |
| 8 | Protein arginine methylation in estrogen signaling and estrogen-related cancers显示文摘 | Teyssier C Le Romancer M Sentis S | 2010 | Trends Endocrinol Metab2010，21，3： | 1 |
| 9 | Transfer of Ku86 RNA antisense decreases the radioresistance of human fibroblasts显示文摘 | Marangoni E Le Romancer M Foray N | 2000 | Cancer Gene Ther2000，7，2： | 1 |
| 10 | On the localization of the personalized PageRank of complex networks显示文摘 | E GARCIA F PEDROCHE M ROMANCE | 2013 | Linear Alge- bra and Its Applications2013，439，3： | 1 |
| 11 | Sumoylation of the e- strogen receptor alpha hinge region regulates itstranscriptional actlvity显示文摘 | Sentis S Le Romancer M Ianchin C | 2005 | Mol Endocrinol2005，19，： | 1 |
| 12 | Transfer of Ku86 RNA antisense decreases the radioresistance of human fibroblasts显示文摘 | Marangoni E Le Romancer M Foray N | 2000 | Cancer Gene Ther2000，7，2： | 1 |
| 13 | Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae显示文摘 | Le Romancer M Gherifi Y Levassenr S | 1996 | Life Sci1996，58，13： | 1 |
| 14 | Controlling centrality in complex networks 显示文摘 | NICOSIA V CRIADO R ROMANCE M | 2012 | Nature: Scientific Re- ports2012，2，218： | 1 |
| 15 | Biological characterization of various geographical isolates of potato virus Y inducing superficial necrosis on potato tubers显示文摘 | Le Romancer M Kerlan C Nedellec M | | 0，，： | 1 |
| 16 | Protein arginine methylation in estrogen signaling and estrogen-related Cancers 显示文摘 | Teyssier C Le Romancer M Sentis S | 2010 | Trends Endocrinol Metab2010，21，3： | 1 |
| 17 | Efficiency, vulnerability and cost: An overview with applications to subway networks worldwide 显示文摘 | Criado R Hernandez - Bermejo B Romance M | 2007 | International Journal of Bifurcation and Chaos2007，17，7： | 1 |
| 18 | CRISPI:a CRISPRinteractive database显示文摘 | ROUSSRAU C GONNET M ROMANCER M L | 2009 | Bioinformatics2009，25，24： | 1 |
| 19 | Cracking the estrogen receptor's posttranslational code in breast tu- mors显示文摘 | Le Romancer M Poulard C Cohen P | 2011 | Endocr Rev2011，32，5： | 1 |
| 20 | Efficiency, vulnerability and cost: An overview with applications to subway networks worldwide 显示文摘 | Criado R Hernandez - Bermejo B Romance M | 2007 | International Journal of Bifurcation and Chaos2007，17，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员