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| 1 | 基于自适应交互进化的设计意图驱动造型显示文摘基于先进的设计认知模型,即工业产品造型设计是问题空间和解决方案空间的协同进化过程,提出了在交互进化计算中引入自适应机制来捕捉并跟踪设计意图的思想,旨在使造型进化过程能够主动迎合设计意图,设计过程中的搜索能够沿着设计师希望的方向自动调整。为验证该思想,基于自适应交互进化策略开发了简单的曲线修改器,并将其用于船体设计作为试验。初步的结果显示了这一概念的可行性和应用潜力。 | 张文莉 左洪福 Dieter Roller | 2006 | 中国机械工程2006，17，4： | 8 |
| 2 | Highly active and durable Pd-Cu catalysts for oxygen reduction in alkaline exchange membrane fuel cells显示文摘 | Xiong PENG Travis J. OMASTA Justin M. ROLLER William E. MUSTAIN | 2017 | Frontiers in Energy2017，11，3： | 7 |
| 3 | Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production显示文摘The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action,high potency and reduced toxicity compared to today's standard drugs.However,production of brasilicardin has been hampered since the producer strain Nocardia terpenica IFM0406 synthesizes brasilicardin in only low amounts and is a biosafety level 2 organism.Previously,we were able to heterologously express the brasilicardin gene cluster in the nocardioform actinomycete Amycolatopsis japonicum.Four brasilicardin congeners,intermediates of the BraA biosynthesis,were produced.Since chemical synthesis of the brasilicardin core structure has remained elusive we intended to produce high amounts of the brasilicardin backbone for semi synthesis and derivatization.Therefore,we used a metabolic engineering approach to increase heterologous production of brasilicardin in A.japonicum.Simultaneous heterologous expression of genes encoding the MVA pathway and expression of diterpenoid specific prenyltransferases were used to increase the provision of the isoprenoid precursor isopentenyl diphosphate(IPP)and to channel the precursor into the direction of diterpenoid biosynthesis.Both approaches contributed to an elevated heterologous production of the brasilicardin backbone,which can now be used as a starting point for semi synthesis of new brasilicardin congeners with better properties. | Paul N.Schwarz Luisa Roller Andreas Kulik Wolfgang Wohlleben Evi Stegmann | 2018 | Synthetic and Systems Biotechnology2018，3，1： | 3 |
| 4 | mRNA expression patterns in different stages of asbestos-induced carcinogenesis in rats显示文摘 | Sanduhu H Dehnen W Roller M | 2000 | Carcinogenesis2000，21，50： | 2 |
| 5 | The antifungal properties of chitosan in laboratory media and apple juice显示文摘 | Roller S Covill N | 1999 | International Journal of Food Microbiology1999，47，： | 1 |
| 6 | Pituitary tumor - transfor- ming gene (PTYG) : a novel target for anti - tumor therapy 显示文摘 | Solbach C Roller M Peters S | 2005 | Anticancer Res2005，25，： | 1 |
| 7 | Pituitary tumor transfor- ming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck显示文摘 | Solbach C Roller M Eckerdt F | 2006 | BMC Cancer2006，9，6： | 1 |
| 8 | Bcl-2 associated athano- gene 5 (Bag5)is overexpressed in prostate cancer and inhibits ER- stress induced apoptosis显示文摘 | Bruchmann A Roller C Walther TV | 2013 | BMC Cancer2013，13，： | 1 |
| 9 | Plasmonic DNA-orlgami nanoantennas for surface-enhanced Raman spectroscopy 显示文摘 | Kuhler P Roller EM Schreiber R | 2014 | Nano Lett2014，14，5： | 1 |
| 10 | Mechanisms of idiosyncratic drug reactions : the case of felbamate 显示文摘 | Dieckhaus C M Thompson C D Roller S G | 2002 | Chem Biol Interact2002，142，12： | 1 |
| 11 | An approach to computeraided quality control based on 3D coordinate metrology显示文摘 | Kai Wolf Dieter Roller Dirk Schafer | 2000 | Journal of Materials Processing Technology2000，，107： | 1 |
| 12 | PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence 显示文摘 | Solbach C Roller M Fellbaum C etal | 2004 | Breast2004，13，1： | 1 |
| 13 | N-nitrosation by nitrite ion in neutral and basic medium显示文摘 | KEEFER L K ROLLER P P | 1973 | Science1973，181，4106： | 1 |
| 14 | Suicide gene thera- py in head and neck carcinoma cells: an in vitro study显示文摘 | Schmidt M Gruensfelder P Roller J | 2011 | Int J Mol Med2011，27，4： | 1 |
| 15 | Shear strength of high-strength concrete beams with web reinforcement 显示文摘 | Roller J J Russell H G | 1990 | ACI Structural Journal1990，87，2： | 1 |
| 16 | Antimicrobial actions of degraded and native chitosan against spoilage organisms in laboratory media and foods显示文摘 | Rhoades J Roller S | 2000 | Applied and Environmental Microbiology2000，66，1： | 1 |
| 17 | An approach to computer aided parametric design显示文摘 | Roller D | | 0，，05： | 1 |
| 18 | An approach to computer-aided parametric design 显示文摘 | Roller D | 1991 | Computer Aided Design1991，23，5： | 1 |
| 19 | An approach to computer aided parametric design显示文摘 | Roller D | 1991 | Computer-Aided1991，23，5： | 1 |
| 20 | Prebiot- ic inulin enriched with oligofmctose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats 显示文摘 | ROLLER M RECHKEMMER G WATZL B | 2004 | The Journal of Nutrition2004，134，1： | 1 |
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