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| 1 | Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk显示文摘 | Ashok V Dash C Rohan TE | 2011 | Breast2011，20，1： | 1 |
| 2 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 3 | Food Research International显示文摘 | Rohan V T Andrew J Nitin N | 2011 | 44 : 1392011，44，： | 1 |
| 4 | Secondary lymphoid-tissue chemokine( SLC ) is chemotatic for mature dendritic cells 显示文摘 | Chan V W Kothakota S Rohan M C | 1999 | Blood1999，93，11： | 1 |
| 5 | Selective cyclooxygenase-2 (cox-2) inhibitors and breast cancer risk显示文摘 | Ashok V Dash C Rohan TE | 2011 | Breast2011，20，1： | 1 |
| 6 | Length of occlusionpredicts recanalization and outcome after intravenousthrombolysis in middlecerebral artery stroke 显示文摘 | Rohan V Baxa J Tupy R | 2014 | Stroke2014，45，7： | 1 |
| 7 | Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in west bohemia显示文摘 | Polivka J Polivka J Jr Rohan V | 2014 | Biomed Res Int2014，2014，73： | 1 |
| 8 | Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia 显示文摘 | Polivka J Polivka J Jr Rohan V | 2014 | Biomed Res hat2014，2014，73： | 1 |
| 9 | Automated infarction core delineation using cerebral and perfused blood volume maps 显示文摘 | Maule P Kleckova J Rohan V | 2013 | Int J Comput Assist Radiol Surg2013，8，5： | 1 |
| 10 | Length of occlusion predicts recanalization and outcome after intravenous thrombolysis in middle cerebral artery stroke显示文摘 | ROHAN V J BAXA TUPY R | 2014 | Stroke2014，45，7： | 1 |
| 11 | Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells显示文摘 | Kothakota S Rohan MC | 1999 | Blood1999，93，： | 1 |
| 12 | Fabrication of Three-Dimensional Substrates for Li M icrobatteries on Si显示文摘 | Jeyaseelan A V Rohan J F | 2009 | Applied Surface Science2009，256，3： | 1 |
| 13 | New molecularly targeted therapies for glioblastoma multiforme显示文摘 | Polivka J Jr Polivka J Rohan V | 2012 | Anticancer Res2012，32，7： | 1 |
| 14 | Isocitrate dehydroge- nase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia显示文摘 | Polivka J Polivka J Rohan V | 2014 | Biomed Res Int2014，2014，1： | 1 |
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