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| 1 | Clinical characteristics and outcome of hepatocellular carcinoma in alcohol related and cryptogenic cirrhosis: a prospective study显示文摘BACKGROUND: Non-alcoholic fatty liver disease(NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma(HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC(cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HCC and those with HCC related to alcoholic cirrhosis. METHODS: A total of 150 consecutive patients with HCC(89 cryptogenic HCC and 61 alcohol related HCC) referred to our unit over a 23-month period were studied. Their demographic data, liver function, tumor characteristics and outcomes were compared.RESULTS: Alcohol related HCC was seen only in males. Compared with cryptogenic HCC, alcohol related HCC had significantly higher aspartate aminotransferase/alanine aminotransferase(AST/ALT) ratio(1.7 vs 1.4, P=0.002), model for endstage liver disease score(13 vs 11, P=0.018) and Child's score(7 vs 6, P=0.037). No significant difference was seen in platelet counts, serum sodium and AST to platelet ratio index. Single nodular tumors were more common in cryptogenic HCC,while diffuse type tumors and macroscopic vascular invasion were common in alcohol related HCC. In patients who could not be offered any treatment because of advanced tumors or poor liver function, alcohol related HCC had a significantly lower median survival(5.3 months) compared with cryptogenic HCC(9.3 months, P=0.034).CONCLUSIONS: Compared with cryptogenic HCC, alcohol related HCC had worse liver function and aggressive tumor morphology at presentation, and a higher proportion was untreatable. In patients who could not be treated, median survival was lower in patients with alcohol related HCC than in those with cryptogenic HCC. | Rohan C Siriwardana Maduni A Niriella Anuradha S Dassanayake Chandika Liyanage Bhagya Gunathilaka Subani Jayathunge Hithanadura J de Silva | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 5 |
| 2 | Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhension molecule-1 inhibition显示文摘 | Miyamoto K Khosrof S Brusell SE Rohan R Murata T Clermont AC | 1999 | Proc Natl Sci USA1999，96，10： | 1 |
| 3 | Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly 显示文摘 | Rohan D Buggy DJ Crewley S | 2005 | Cart J Anaesth2005，52，2： | 1 |
| 4 | Requirment for vascular endothelial growth factor in wound and inflammation-related corneal neovascularization显示文摘 | Amano S Rohan R Kuroki M | 1998 | Invest Ophthalmol Vis Sci1998，39，5： | 1 |
| 5 | 'Proactive' ma-nagement of percutaneously inserted central catheters results in decreased incidence of infection in the ELBW population显示文摘 | Golombek S G Rohan A J Parvez B | 2002 | J Perinatol2002，22，3： | 1 |
| 6 | Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly显示文摘 | Rohan D Buggy DJ Crowley S | 2005 | Can J Anaesth2005，52，2： | 1 |
| 7 | Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition显示文摘 | Miyamoto K Khosrof S Bursell SE Rohan R Murata T Clermont AC | 1999 | Proc Natl Acad Sci USA1999，96，19： | 1 |
| 8 | Requirmentfor vascular endothelial growth factor in wound and inflammation-related corneal neovascularization显示文摘 | Amano S Rohan R Kuroki M | 1998 | Invest Ophthalmol Vis Sci1998，39，5： | 1 |
| 9 | Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization显示文摘 | Amano S Rohan R Kuroki M | | 0，，01： | 1 |
| 10 | Human papillomavirus infections with multiple types and risk of cervical neoplasia 显示文摘 | Trottier H Mahmud S Costa MC Sobfinho JP Duarte - Franco E Rohan TE | 2006 | Cancer Epidemiol Biomarkers Prey2006，15，： | 1 |
| 11 | Chemically mediated rejection of dinoflagellate prey by the copepods Calanus pacificus and Paracalanus parvus:mechanisms, occurrence significance 显示文摘 | Huntley M E Sykes P Rohan S | 1986 | Mar Ecol Prog Ser1986，28，： | 1 |
| 12 | p53 alterations andprotein accmulation in benign breast tissue and breast cancer risk:acohort study显示文摘 | Rohan T E Li S Q Hartwick R Kandel R A | 2006 | Cancer Epidemiol Biomarkers Prev2006，15，： | 1 |
| 13 | In situ analysis of the changes in expression of ovarian inhibin subunit mRNAs during follicle recruitment after ovulation in pigs显示文摘 | Garrett W M Mack S O Rohan R M | 2000 | Journal of Reproduction and Fertility2000，118，： | 1 |
| 14 | Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly显示文摘 | Rohan D Buggy DJ Crowley S | 2005 | Can J Anaesth2005，52，2： | 1 |
| 15 | Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues显示文摘 | Tu J J Rohan S Kao J | 2007 | Modern Pathology2007，20，9： | 1 |
| 16 | Requirement for vascular endothelial growth factor in wound-and inflammation-related corneal neovascularization显示文摘 | Amano S Rohan R Kuroki M Tolentino M Adamis AP | 1998 | Invest Ophthalmol Vis Sci1998，39，1： | 1 |
| 17 | Increased incidence of post- operative cognitive dysfunction 24 hr after minor surgery in the elderly显示文摘 | Rohan D Buggy DJ Crowley S | 2005 | Can J Anesth2005，52，2： | 1 |
| 18 | Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly显示文摘 | Rohan D Buggy DJ Crowley S | 2005 | Can J Anaesth2005，52，2： | 1 |
| 19 | Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly显示文摘 | Rohan D Buggy DJ Crowley S | 2005 | Can J Anaesth2005，52，2： | 1 |
| 20 | Cognitive-behavioral factors in seasonal affective disorder显示文摘 | Rohan K Sigmon S and Dorhofer D | 2003 | Journal of Consuiting and Clinical Psychology2003，71，1： | 1 |
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