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| 1 | 基于信号质量评估和卡尔曼滤波的心率估计算法显示文摘目的:研究基于多导重症监护导联心电分析的逐搏心率估计算法。方法:通过开放源码的QRS搏动识别算法计算逐搏心率,通过分析信号的波形特征、统计特性和相互关系导出反映信号质量好坏的信号质量指数(signalqualityindex,SQI)。应用基于信号质量指数调节的卡尔曼滤波方法进行心率估计,通过残差值和信号质量指数的大小来动态调节卡尔曼滤波器的状态变量,获得逐搏心率的最佳估计。应用美国麻省理工学院多参数智能重症监护数据库II中437例病人的6000多小时高质量数据和人为添加真实心电干扰的数据进行算法评价。结果:与直接心率估计及采样保持等算法比较,本算法在严重干扰存在时,心率估计的均方根误差最小。结论:基于信号质量评估和卡尔曼滤波的心率估计算法在严重干扰存在时仍能提供精确的心率估计。 | 李桥 Roger G Mark Gari D Clifford 俞梦孙 | 2007 | 中国医学物理学杂志2007，24，6： | 8 |
| 2 | Metal exposure and Alzheimer's pathogenesis.显示文摘 | Liu G Huang W Moir RD Vanderburg CR Lai B Peng Z Tanzi RE Rogers JT Huang X | 2006 | 中国生物学文摘2006，20，9： | 8 |
| 3 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients. | QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 6 | Imaging ellipsometry revisited: developments for visualization of thin transparent layers on silicon substrates显示文摘 | JIN G ROGER J HANS A | 1996 | Review of Scientific Instrument1996，67，8： | 2 |
| 7 | High-resolution ultrasound to diagnose melanoma metastases in patients with clinically palpable lymph nodes显示文摘 | Uren R Howman G | 1999 | Australasian Radiology1999，43，： | 1 |
| 8 | Modeling discontinuous axisymmetric active optical membranes显示文摘 | Roger J Agnes G | 2003 | Journal of Spacecraft and Rockets2003，40，4： | 1 |
| 9 | Cullivation of murine hair follicles as organoids in a collagen matrix显示文摘 | Rogers G Martinet N Steinert P | 1987 | J Invest Dermatol1987，89，4： | 1 |
| 10 | Biosynthesis of alkanes by particulate and solubilized enzyme preparations from pea leaves (Pisum sativum) 显示文摘 | Bognar A L Paliyath G Rogers L | 1984 | Arch Biochem Biophys1984，235，： | 1 |
| 11 | Five - year follow - up of percutaneous vena cava filters in high - risk trauma patients显示文摘 | Rogers FB Strindberg G Shachford SR | 1998 | Arch Surg1998，133，： | 1 |
| 12 | Controlling culture dynamics for the expansion of hematopoietic stem cells 显示文摘 | Madlambayan G J Rogers I Casper RF | 2001 | J Hematother Stem Cell Res2001，10，： | 1 |
| 13 | Printing,molding, and near-field photolitho graphic methods for patterning organic lasers, smart pixels and simple circuits 显示文摘 | Rogers J A Whitesides G M | 2000 | Synthetic Metals2000，，115： | 1 |
| 14 | Root to shoot ratio of crops as influenced by CO2显示文摘 | Rogers H H Prior S A Runion G B | 1996 | Plant Soil1996，187，： | 1 |
| 15 | Episodic Tremor and Slip on the Cascadia Subduction Zone: The Chatter of Silent Slip显示文摘 | Rogers G Dragert H | 2003 | Science2003，300，： | 1 |
| 16 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 17 | Nonlinear wavelet transforms for image coding via lifting显示文摘 | Roger L C Davis G M Sweldens W | 2003 | IEEE Transactions on Image Process2003，12，12： | 1 |
| 18 | Berger, statistical inference显示文摘 | Casella G Roger L | 2008 | California: Brooks/Cole2008，，： | 1 |
| 19 | Catheter - related blood stream in - fection rates in a mixed - medical - surgical ICU population be- fore and after the implementation of a central line bundle 显示文摘 | Soni RA Rogers G Valenti A | 2008 | Chest2008，134，： | 1 |
| 20 | Dielectric properties of M-type barium hexaferrite prepared by co-precipitation显示文摘 | Kajal K M Roger J G | | 0，，04： | 1 |
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