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| 1 | Ion beam analysis of PECVD silicon oxide thin films 显示文摘 | FERNANDEZ-LIMA F RODRIGUEZ J A PEDRE- RO E | 2006 | Nuclear Instruments and Methods in Physics Research B: Beam Interactions with Materials and Atoms2006，243，1： | 1 |
| 2 | Gender differences in p53 mutational status in small cell lung cancer显示文摘 | Tseng JE Rodriguez M Ro J | 1999 | Can Res1999，59，22： | 1 |
| 3 | Alignment of collagen and laminin-containing gels improve nerve egeneration within silicone tubes显示文摘 | Verdu E Labrador RO Rodriguez FJ | 2002 | Restor Neurol Neurosci2002，20，5： | 1 |
| 4 | Functional assessment of human femoral arteries after erypreservation显示文摘 | Esther Rendal Vazquez M Rodriguez Cabareos M Fernandez Mallo Ro | 2004 | Cryobiology2004，49，1： | 1 |
| 5 | Alignment of collagen and laminin-containing gels improve nerve regeneration within silicone tubes显示文摘 | Verdu E Labrador RO Rodriguez FJ | 2002 | Restor Neurol Neurosci2002，20，5： | 1 |
| 6 | Alignment of collagen and laminin-containing gels improve nerve regeneration within silicone tubes显示文摘 | Verdu E Labrador RO Rodriguez FJ | 2002 | Rsetor Neural Neurosci2002，20，5： | 1 |
| 7 | Induction of neutralizing antibodies and partial protection from viral challenge in Macaea fascicularis immunized with recombinant dengue 4 virus envelope glycoprotein expressed in Pichia pastoris 显示文摘 | Guzman MA Rodriguez RA Rodriguez RO | 2003 | Am J Trop Med Hyg2003，69，2： | 1 |
| 8 | Improvement of regeneration with predegenerated nerve transplants in silicone chambers显示文摘 | Rodriguez FJ Gomez N Labrador RO | 1999 | Restor Neurol Neurosci1999，14，1： | 1 |
| 9 | Functional assessment of human femoral arteries after cryopreservation 显示文摘 | Esther Rendal Vazquez M Rodriguez Cabarcos M Femandez Mallo RO | 2004 | Cryobiology2004，49，1： | 1 |
| 10 | Alignment of collagen and laminin-containing gels improve nerve regeneration within silicone tubes显示文摘 | VerddE Labrador RO Rodriguez FJ | 2002 | Restor Neurol Neurosci2002，20，5： | 1 |
| 11 | Gender differences in p53 mutational status in small cell lung cancer显示文摘 | Tseng JF Rodriguez M Ro J | 1999 | Can Res1999，59，22： | 1 |
| 12 | Procedure for microbial identification based on matrix-assisted laser desorption/ionization:time of flight mass spectrometry from screening-positive urine samples 显示文摘 | March Rosselle GA Gutierrez Rodriguez MP de Lejarazu Le- onardo RO | 2014 | APMIS2014，122，9： | 1 |
| 13 | Presence of c.3956del C mutation in familial adenomatous polyposis patients from Brazil显示文摘AIM: To characterize APC gene mutations and correlate them with patient phenotypes in individuals diagnosed with familial adenomatous polyposis(FAP) in northern Brazil. METHODS: A total of 15 individuals diagnosed with FAP from 5 different families from the north of Brazil were analyzed in this study. In addition to patients with histopathological diagnosis of FAP,family members who had not developed the disease were also tested in order to identify mutations and for possible genetic counseling. All analyzed patients or their guardians signed a consent form approved by the Research Ethics Committee of the Jo?o de Barros Barreto University Hospital(Belem,Brazil). DNA extracted from the peripheral blood of a member of each of the affected families was subjected to direct sequencing. The proband of each family was sequenced to identify germline mutations using the Ion Torrent platform. To validate the detected mutations,Sanger sequencing was also performed. The samples from all patients were also tested for the identification of mutations by real-time quantitative polymerase chain reaction using the amplification refractory mutation system. RESULTS: Through interviews with relatives and a search of medical records,it was possible to construct genograms for three of the five families included in the study. All 15 patients from the five families with FAP exhibited mutations in the APC gene,and all mutations were detected in exon 15 of the APC gene. In addition to the patients with a histological diagnosis of FAP,family members without disease symptoms showed the mutation in the APC gene. In the present study,we detected two of the three most frequent germline mutations in the literature: the mutation at codon 1309 and the mutation at codon 1061. The presence of c.3956 del C mutation was found in all families from this study,and suggests that this mutation was introduced in the population of the State of Pará through ancestor immigration(i.e.,a de novo mutation that arose in one member belonging to this state from Brazil). CONCLUSION: Regardless of its origin,the c.3956 del C mutation is a strong candidate biomarker of this hereditary cancer syndrome in families of northern Brazil. | Caroline Aquino Moreira-Nunes Diego di Felipe ávila Alcantara Sérgio Figueiredo Lima-Júnior Sandro Roberto de Araújo Cavalléro Juan Antonio Rey Giovanny Reboucas Pinto Paulo Pimentel de Assumpcao Rommel Rodriguez Burbano | 2015 | World Journal of Gastroenterology2015，21，31： | 0 |
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