|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Laparoscopic approach in gastrointestinal emergencies显示文摘This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go. | Rosa M Jimenez Rodriguez Juan José Segura-Sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz | 2016 | World Journal of Gastroenterology2016，22，9： | 5 |
| 3 | Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs 显示文摘 | Garcia Rodriguez L A Hernandez Diaz S | 2004 | Am J Epidemiol2004，159，1： | 1 |
| 4 | Abscisic acid: Emergence of a core signaling network 显示文摘 | CUTLER S R RODRIGUEZ P L FINKELSTEIN R R | 2010 | Annu Rev Plant Biol2010，61，3： | 1 |
| 5 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 6 | Cerebrotendinous xanthomatosis 显示文摘 | Bel S Garcia-Patos V Rodriguez L | 2001 | J Am Acad Dermatol2001，45，2： | 1 |
| 7 | The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs显示文摘 | Rodriguez S Wang L Mumaw C | 2011 | Blood2011，117，24： | 1 |
| 8 | Rapid detection of vesicular stomatitis virus New Jersey serotype in clinical samples by using polymerase chain reaction显示文摘 | Rodriguez L L Lecthworth G J Nichol S T | 1993 | J Clin Microbiol1993，31，： | 1 |
| 9 | Helicobacter pylori infection and gastric lymphoma 显示文摘 | Parsonnet J Hansen S Rodriguez L | 1994 | N Engl J Med1994，330，： | 1 |
| 10 | Novel chemotherapy approaches for cervical cancer显示文摘 | Movva S Rodriguez L Arias-Pulido H | | 0，，14： | 1 |
| 11 | 查看详情显示文摘 | Rodriguez B J Gao X S Liu L F | | 0，，： | 1 |
| 12 | New objective measures to quantify stress urinary incontinence in a novel durable animal model of intrinsic sphincter deficiency显示文摘 | RODRIGUEZ L V CHEN S JACK G S | 2005 | Am J Physiol Regul Integr Comp Physiol2005，288，5： | 1 |
| 13 | Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas:critical role in resistance to Toll-like receptor 3mediated apoptosis显示文摘 | Friboulet L Pioche-Durieu C Rodriguez S | 2008 | Neoplasia2008，10，11： | 1 |
| 14 | Helicobacter pylori infection and gastric lymphoma显示文摘 | Parsonnet J Hansen S Rodriguez L | 1994 | N Engl J Med1994，330，： | 1 |
| 15 | Identifi- cation of mammalian microRNA host genes and transcrip- tion units显示文摘 | Rodriguez A Griffiths-J ones S Ashurst J L | 2004 | Genome Res2004，14，10： | 1 |
| 16 | Study of the GC-MS determination of the palmitic-stearic acid ratio for the characterisation of drying oil in painting显示文摘 | MANZANO E L R RODRIGUEZ S NAVAS N | 2011 | Talanta2011，84，4： | 1 |
| 17 | Volatile emissions triggered by multiple herbivore damage: beet army- worm and whitefly feeding on cotton plants显示文摘 | Rodriguez Saona C Crafts-Brandner S J Cafias L A | 2003 | Journal of Chemical Ecology2003，29，11： | 1 |
| 18 | Novel chemotherapy approaches for cervical cancer 显示文摘 | Movva S Rodriguez L Arias-Pulido H | 2009 | Cancer2009，115，14： | 1 |
| 19 | Effects of insulin on the fine structure of hepatocytes from winter-acclimatized carps: studies on protein synthesis显示文摘 | Sáez L Amthauer R Rodriguez E | 1984 | J Exp Zool1984，230，： | 1 |
| 20 | Parenting styles in a cultural context:Observations of 'protective parenting' in first --generation Latinos显示文摘 | Domenech Rodriguez M M Donovick M R Crowley S L | 2009 | Fam Process2009，48，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员