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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas显示文摘AIM To correlate Helicobacter pylori(H. pylori), Epstein-Barr virus(EBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms. | Carolina Rosal Teixeira de Souza Marcelli Carolini Alves Almeida Andre Salim Khayat Emerson Lucena da Silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano | 2018 | World Journal of Gastroenterology2018，24，43： | 6 |
| 3 | Infrared fluorescence imaging of infarcted hearts with A@S nanodots显示文摘Ag2S nano dots have already bee n dem onstrated as promisi ng n ear-i nfrared (NIR-II, 1.0-1.45 pm) emitting nan oprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the pote ntial applicati on of function alized Ag2S nano dots for accurate imaging of damaged myocardium tissues after a myocardial in farction in duced by either partial or global ischemia. Ag2S nano dots surface-function alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an in direct evaluati on of the damage level. The pote ntial applicati on of Ag2S nano dots in the n ear future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments. | Dirk H. Ortgies Angel Luis Garcia-Villalon Miriam Granado Sara Amor Emma Martin Rodriguez Harrisson DA Santos Jingke Yao Jorge Rubio-Retama Daniel Jaque | 2019 | Nano Research2019，12，4： | 2 |
| 4 | Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lefdependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression显示文摘 | Rodriguez DA Tapia JC Fernandez JG | 2009 | Mol Biol Cell2009，20，8： | 1 |
| 5 | BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1 alpha显示文摘 | Rodriguez DA Zamorano S Lisbona F | 2012 | EMBO J2012，31，10： | 1 |
| 6 | E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lefdependent transcription显示文摘 | Tortes VA Tapia JC Rodriguez DA | 2007 | Mol Cell Biol2007，27，： | 1 |
| 7 | The 18-whell mutation reveals complex antibacterial gene regulation in drosophila host defence显示文摘 | Rodriguez A Kimbell DA | 1997 | EMBO J1997，16，： | 1 |
| 8 | Survivin ex- pression promotes VEGF-induced tumor angiogenesis via PI3 K/Akt enhanced β-catenin/Tcf-Lef dependent transcription 显示文摘 | Ferandez JG Rodriguez DA Valanzuela M | 2014 | Mol Cancer2014，13，： | 1 |
| 9 | A structural rearrangement of the Na /K -AT- Pase traps ouabain within the external ion permeation pathway 显示文摘 | SANCHEZ- RODRIGUEZ J E KHALILI- ARAGHI F MIRAN- DA P | 2015 | J Mol Biol2015，427，6： | 1 |
| 10 | Casein kinase 2 ( CK2 ) increases survivin expression vienhanced β-catenin-T cell factor/ lymphoid enhancer binding factor-dependent transcription显示文摘 | Tapia JC Tones VA Rodriguez DA | 2006 | Proe Natl Acad Sci USA2006，103，15： | 1 |
| 11 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | Am Acad Dermatol1997，37，： | 1 |
| 12 | The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense显示文摘 | Williams MJ Rodriguez A Kimbrell DA | 1997 | EMBO J1997，16，： | 1 |
| 13 | Intensified versus conventional management of gestational diabetes显示文摘 | Langer O Rodriguez DA Xenakis EM | 1994 | Am J Obstet Gynecol1994，170，： | 1 |
| 14 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | J Am Acad Dermatol1997，37，： | 1 |
| 15 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | J Am Acad Dermatol1997，37，21： | 1 |
| 16 | A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine,a new antifungal agent显示文摘 | Greer DL Weiss J Rodriguez DA | 1997 | J Am Acad Dermatol1997，37，： | 1 |
| 17 | Ethanol increases tumor necrosis factor-alpha receptor-1(TNF-R1)levels in hepatic,intestinal,and cardiac cells显示文摘 | Rodriguez DA Moncada C Nunez MT | 2004 | Alcohol2004，33，1： | 1 |
| 18 | Intensihed versus con- ventional management of gestational diabetes 显示文摘 | Langer O Rodriguez DA Xenakis EM | 1994 | Am J ObstetGynecol1994，，170： | 1 |
| 19 | Caveolin-1-mediatedSuppression of Cyclooxygenase-2 via a β-catenin-Tcf/Lef-dependentTranscriptional Mechanism Reduced Prostaglandin E2 Productionand Survivin Expression显示文摘 | Rodriguez DA Tapia JC Fernandez JG | 2009 | Mol Biol Cell2009，20，8： | 1 |
| 20 | Oxidative stress, redox signaling pathways, and autophagy in eaeheetie mus- cles of male patients with advanced COPD and lung cancer 显示文摘 | Puig-Vilanova E Rodriguez DA Lloreta J | 2015 | Free Radie Biol Med2015，79，： | 1 |
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