|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Oleanolic acid promotes healing of acetic acid - induced chronic gastric lesions in rats显示文摘 | Rodriguez J A Astudillo L Schmeda - Hirschmann G | 2003 | Pharmacol Res2003，48，3： | 1 |
| 3 | Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog 显示文摘 | Gallet A Rodriguez R Ruel L | 2003 | Dev Cell2003，4，2： | 1 |
| 4 | Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs 显示文摘 | Garcia Rodriguez L A Hernandez Diaz S | 2004 | Am J Epidemiol2004，159，1： | 1 |
| 5 | Stereotactic biopsy for brainstem tumors in pediatric patients 显示文摘 | PEREZ GOMEZ J L RODRIGUEZ ALVAREZ C A MARHX BRACHO A | 2010 | Childs Nerv Syst2010，26，1： | 1 |
| 6 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 7 | Effects of inulin and enzyme complex, individually or in combination, on growth performance, intestinal mi- croflora, cecal fermentation characteristics, and jejunal histomorphology in broiler chickens fed a wheat-and barley-based diet显示文摘 | REBOLE A ORTIZ L T RODRIGUEZ M L | 2010 | Poultry Science2010，89，2： | 1 |
| 8 | Gout and risk of Parkinson disease: a prospective study显示文摘 | Alonso A Rodriguez L A Logroscino G | 2007 | Neurology2007，69，17： | 1 |
| 9 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 10 | Accuracy and predictive value of classification schemes for ketosis-prone diabetes显示文摘 | Balasubramanyam A Garza G Rodriguez L | 2006 | Diabetes Care2006，29，12： | 1 |
| 11 | Alterations in membrane fiuidity of diabetic polymorphonuclear leukocytes Biochem显示文摘 | Kantar A Kurose L Rodriguez V D | 1991 | Med Metab Biol1991，46，： | 1 |
| 12 | The role of capillary water in the stability of tailing dams 显示文摘 | Zandarfn M T Oldecop L A Rodriguez R | 2009 | Engineering Geology2009，105，2： | 1 |
| 13 | Neonatal expression of amh, sox9 and sf-1 mRNA in Caiman latirostris and effects of in ovo exposure to endocrine disrupting chemicals 显示文摘 | Durando M Cocito L Rodriguez H A | 2013 | General and Comparative Endocrinology2013，191，1： | 1 |
| 14 | preimplantation genetic diagnosis for spinal muscular atrophy type I 显示文摘 | Fallon L Harton GL Sisson ME Rodriguez E Field LK Fugger EF Geltinger M Sun Y Dorfmann A Schoener C Bick Dm Schulman J Levinson G Black SH | 1999 | Neurology1999，53，： | 1 |
| 15 | Gastro- protective activity of oleanoJic acid derivatives on experimentally induced gastric lesions in rats and mice 显示文摘 | Astudillo L Rodriguez J A Schmeda-Hirschmann G | 2002 | J Pharm Pharmacol2002，54，4： | 1 |
| 16 | Effect of cryopreservation on fusion efficiency and in vitro development into blastocysts of bovine cell lines used in somatic cell cloning显示文摘 | Hayes O Rodriguez L Gonzalez A | 2005 | Zygote2005，13，4： | 1 |
| 17 | Prospective e- valuation of imipenem/EDTA combined disc and Etest for detection of metallo - beta - lactamase - producing Pseudomonas aeruginosa 显示文摘 | Berges L Rodriguez - Villalobos H Deplano A | 2007 | Antimicrob Chemother2007，59，4： | 1 |
| 18 | Open label, prospectire, randomized controlled trial of an endoscopic duodenal-jejunal bypass sleeve versus low calorie diet for pre-operative weight loss in bariatric surgery显示文摘 | Tarnoff M Rodriguez L Escalona A | 2009 | Surg Endosc2009，23，3： | 1 |
| 19 | New information on the pyrite bioleaching mechanism at low and high temperature显示文摘 | RODRIGUEZ Y BALLESTER A BLAZQUEZ M L | 2003 | Hydrometallurgy2003，71，： | 1 |
| 20 | High rate of durable remissions after treatment of newly diagnosed ag- gressive mantle - cell lymphoma with rituximab plus hyper - CVAD alternating with rituximab plus high - dose methotrexate and cytara- bine显示文摘 | ROMAGUERA J E FAYAD L RODRIGUEZ M A | 2005 | J Clin Oncol2005，23，28： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员