|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation显示文摘AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal inflammation.METHODS The animals were divided into groups that received vehicle or P.angulata extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS damage.Protective effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)microscopy.RESULTS PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil infiltration.These effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control animals.In addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural analysis.CONCLUSION Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease. | luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 2 | My- cobacterial heat shock protein 70 induces interleu- kin-10 production: immunomodulation of synovial cell cytokine profile and dendritic cell maturation 显示文摘 | Detanico T Rodrigues L Sabritto AC | 2004 | ClinExp Immunol2004，135，2： | 1 |
| 3 | Physicochemical and harvest time akerations in pineapple fruits 'Smooth Cayenne' caused by paclobutrazol 显示文摘 | Antunes AM Ono EO Sampaio AC Rodrigues JD | 2008 | Brazilian Archives of Biology and Technology2008，51，1： | 1 |
| 4 | Antifungal activi-ty of local anesthetics against Candida species显示文摘 | Pina-Vaz C Rodrigues AC Sansonelty F | 2000 | Infect Dis ObstetGynecol2000，8，1： | 1 |
| 5 | Choroidal vesselsalterations in treated and untreated diabetic rats显示文摘 | Rodrigues AC Schellini SA Spadela CT | 2007 | Arq BrasOftalmol2007，70，： | 1 |
| 6 | The coronary circulation of the pig heart:comparison with the human heart显示文摘 | Rodrigues M Silva AC Grande NR | 2005 | Eur J Anat2005，9，2： | 1 |
| 7 | Phacoemulsification using clear cornea incision in steepest meridian显示文摘 | Goncalves FP Rodrigues AC | 2007 | Arq Bras Oftalmol2007，70，： | 1 |
| 8 | High baseline serum total and LDL cholesterol levels are associated with MDR1 haplotypes in Brazilian hypercholesterolemic individuals of European descent显示文摘 | Rodrigues AC Rebecchi IM Bertolami MC | | 0，，09： | 1 |
| 9 | Evaluation in melano- ma-beating mice of an etoposide derivative associated to a cholesterol- rich nano-emulsion显示文摘 | Lo Prete AC Mafia DA Rodrigues DG | 2006 | J Pharm Pharmacol2006，58，6： | 1 |
| 10 | Day-night pattern of autonomic nervous system modulation in patients with heart failure with and without sleep apnea 显示文摘 | Ueno LM Drager LF Rodrigues AC | 2011 | Int J Cardio12011，148，1： | 1 |
| 11 | Is drooling secondary to a swallowing disorder in patients with Parkinson's disease显示文摘 | Nóbrega AC Rodrigues B Torres AC | | 0，，： | 1 |
| 12 | Dense ceramics of NaNbO3 produced from powders prepared by a new chemical route显示文摘 | Lanfredi S Dessemond L Martins AC Rodrigues | | Journal of the European Ceramic Society0，，： | 1 |
| 13 | pH-cycling model to verify the efficacy of fluoride-releasing materials in enamel demineralization显示文摘 | Rodrigues E Delbem AC Pedrini D | 2008 | Oper Dent2008，33，6： | 1 |
| 14 | Effect of the peroxisome proliferator-activated receptor-gamma C161T polymorphism on lipid profile in Brazilian patients with Type 2 diabetes mellitus显示文摘 | Tavares V Hirata RD Rodrigues AC | 2005 | Endocrinol Invest2005，28，2： | 1 |
| 15 | Day - night pattern of autonomic nervous system modulation in patients with heart failure with and without sleep apnea 显示文摘 | Ueno LM Drager LF Rodrigues AC | 2011 | Int J Cardiol2011，148，1： | 1 |
| 16 | Satellite cells and myonuclei in long-term denervated rat muscles显示文摘 | Rodrigues AC Schmalbruch H | 1995 | Anat Ree1995，243，4： | 1 |
| 17 | Accuracy of stone casts obtained by different impression materials显示文摘 | Faria AC Rodrigues RC Macedo AP | | 0，，04： | 1 |
| 18 | KPC-2-producing Kleb- siella pneumoniae in a hospital in the Midwest region of Brazil 显示文摘 | Biberg CA Rodrigues AC do Camlo SF | 2015 | Braz J Mierobiol2015，46，2： | 1 |
| 19 | Decision-making capecity and surrogate designation in French ICU patients显示文摘 | Ferrand E Bachoud-Levi AC Rodrigues M | 2001 | Intensive Care Med2001，27，8： | 1 |
| 20 | Ethanol production from sugarcane bagasse by Zymomonas mobilis using simultaneous saccharification and fermentation (SSF) process 显示文摘 | dos Santos Dda S Camelo AC Rodrigues KC Carlos LC Pereira N Jr | 2010 | Appl Biochem Biotechnol2010，161，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员