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| 1 | Current and future therapies for inherited cholestatic liver diseases显示文摘Familial intrahepatic cholestasis(FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phe-notypes range from benign recurrent intrahepatic cholestasis(BRIC), associated with recurrent cholestatic attacks, to progressive FIC(PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency(PFIC3) and partial biliary diversion in patients with ATP8B1 or ABCB11 deficiency(PFIC1 and PFIC2). When treatment fails, liver transplantation is needed which is associated with complications like rejection, post-transplant hepatic steatosis and recurrence of disease. Therefore, the need for more and better therapies for this group of chronic diseases remains. Here, we discuss new symptomatic treatment options like total biliary diversion, pharmacological diversion of bile acids and hepatocyte transplantation. Furthermore, we focus on emerging mutation-targeted therapeutic strategies, providing an outlook for future personalized treatment for inherited cholestatic liver diseases. | Wendy L van der Woerd Roderick HJ Houwen Stan FJ van de Graaf | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 2 | SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer显示文摘 | Andreas I Papadakis Chong Sun Theo A Knijnenburg Yibo Xue Wipawadee Gremrum Michael Holzel Wouter Nijkamp Lodewyk FA Wessels Roderick L Beijersbergen Rene Bernards Sidong Huang | 2015 | Cell Research2015，25，4： | 4 |
| 3 | The Physical and Mathematical Modelling of Continuous Casting Tundish Systems显示文摘 | Dipak Mazumdar Roderick I L | 1999 | ISIJ International1999，39，6： | 1 |
| 4 | Calcium phosphate crystals induce cell death in human vascular smooth muscle cells显示文摘 | Ewence A E Bootman M Roderick H L | 2008 | Circ Res2008，103，： | 1 |
| 5 | The Cause of Decreased Pan Evaporation over the Past 50 Years显示文摘 | Michael L Roderick Graham D Farquhar | 2002 | Science2002，298，： | 1 |
| 6 | Direct dating of sulfides by Rb-Sr:Acritical test using the Polaris Mississippi Valley-type Zn-Pb deposit显示文摘 | Christensen J N Halliday A N Kenneth E L Roderick N R and Stephen E K | | 0，，： | 1 |
| 7 | On the direct effect of clouds and atmospheric particles on the productivity and structure of vegetation显示文摘 | Roderick M L Farquhar G D Berry S L | 2001 | Oecologia2001，129，： | 1 |
| 8 | The cause of decreased pan evapora- tion over the past 50 years 显示文摘 | Roderick M L Farquhar G D | 2002 | Science2002，295，15： | 1 |
| 9 | The cause of decreased pan evaporation over the past 50 years 显示文摘 | Farquhar G D | 2002 | Science2002，298，： | 1 |
| 10 | The cause of decreased pan evaporation over the past 50 years显示文摘 | Roderick M L Farquhar G D | 2002 | Science2002，298，： | 1 |
| 11 | Changes in Australian pan evap- oration from 1970 to 2002显示文摘 | Roderick M L Farquhar G D | 2004 | International Journal of Clima- tology2004，24，9： | 1 |
| 12 | On the direct effect of clouds and atmospheric particles on the productivity and structure o f vegetation显示文摘 | Roderick M L Farquhar G D Berry S L | 2001 | Oecologia2001，129，1： | 1 |
| 13 | Deriving consistent long-term vegetation information from AVHRR reflectance data using a cover-triangle-based framework显示文摘 | Donohue R J Roderick M L McVicar T R | 2008 | Remote Sensing of Environment2008，112，6： | 1 |
| 14 | The cause of decreased pan evaporation over the past 50 years显示文摘 | Farquhar G D | 2002 | Science2002，298，15： | 1 |
| 15 | Hydrodynamic Performance of Steelmaking Tundish Systems: a Comparative Study of Three Different Designs显示文摘 | YAMANOGL Guler GUTHRIE Roderick I L | 1997 | Steel Research1997，68，7： | 1 |
| 16 | Calcium signalling:dynamics,homeostasis and remodelling显示文摘 | BERRIDGE M J BOOTMAN M D RODERICK H L | 2003 | Nature Reviews Molecular Cell Biology2003，4，7： | 1 |
| 17 | The cause of decreased pan evaporation over the past 50 years显示文摘 | Roderick M L Farquhar G D | 2002 | Science2002，298，15： | 1 |
| 18 | Identification and characterization of an amino acid transporter expressed dif- ferentially in liver显示文摘 | GU S RODERICK H L CAMACHO P | 2000 | Proc Natl Acad Sci USA2000，97，7： | 1 |
| 19 | The use of time-integrated NOAA NDVI data and rainfall to assess landscape degradation in the arid shrubland of Western Australia显示文摘 | Alexander McR Holma Shane W Cridlandb Michael L Roderick | 2003 | Remote Sensing of Environment2003，85，： | 1 |
| 20 | The use of time-integrated NOAA NDVI data and rainfall to assess landscape degradation in the arid shrubland of Western Australia显示文摘 | Holm A M R Cridland S W Roderick M L | 2003 | Remote Sensing of Environment2003，85，2： | 1 |
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