|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Melatonin and male reproductive health:relevance of darkness and antioxidant properties 显示文摘 | Rocha CS Rato L Martins AD | 2015 | Curr Mol Med2015，15，4： | 1 |
| 3 | Microencapsulationof lycopene by gelatin–pectin complex coacervation显示文摘 | Silva DF Fávaro-Trindade CS Rocha GA | 2012 | JFood Process Preservation2012，36，2： | 1 |
| 4 | Microencapsu- lation of Lycopene by spray drying: characterization; stability and application of microcapsules 显示文摘 | Rocha GA Favaro - Trindade CS Grosso CRF | 2011 | Food and Bioproducts Processing2011，226，： | 1 |
| 5 | Use of performance indicators in the nursing service of a public hospital显示文摘 | Gabriel CS Melo MR Rocha FL | 2011 | Rev Lat Am Enfermagem2011，19，5： | 1 |
| 6 | Multidirectional pelvic floor muscle strength measurement显示文摘 | Saleme CS Rocha DN Del Vecchio S | | 0，，08： | 1 |
| 7 | Eplerenone: a selective aldosterone receptor antagonist (SARA)显示文摘 | Delyani JA Rocha R Cook CS | | 0，，： | 1 |
| 8 | Eplerenone:a selective aldosterone receptor antagonist(SARA)显示文摘 | Delyani JA Rocha R Cook CS | 2001 | Cardiovasc Drug Rev2001，19，3： | 1 |
| 9 | Interferential therapy effect on mechanical pain threshold and isometric torque after delayed onset muscle soreness induction in human hamstrings显示文摘 | Rocha CS Lanferdini FJ Kolberg C | 2012 | J Sports Sci2012，30，8： | 1 |
| 10 | GVHD dry eye treated with autologous serum tears 显示文摘 | Rocha EM Pelegrino FSA de Paivs CS | 2000 | Bone Marrow Transplan- tation2000，25，10： | 1 |
| 11 | Eplerenone: a selective aldosterone receptor antagonist(SARA)显示文摘 | Delyani JA Rocha R Cook CS | 2001 | Cardiovasc Drug Rev2001，19，3： | 1 |
| 12 | Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy显示文摘 | Rocha CN Miziara CS Manreza ML | 2010 | Arq Neuropsiquiatr2010，68，1： | 1 |
| 13 | Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-gamma genes and its association with susceptibility to tuberculosis 显示文摘 | Leandro AC Rocha MA Cardoso CS | 2009 | Braz J Med Biol Res2009，42，4： | 1 |
| 14 | Eplerenone : A selective aldosterone receptor antagonist (SARA) 显示文摘 | Delyani JA Rocha R Cook CS | 2001 | Cardiovasc Drug Rev2001，19，3： | 1 |
| 15 | Office blood Pressure and24- hour ambulatory blood Pressure measurements : high proportion of disagreement in resistant hypertension 显示文摘 | Rodrigues CS Bloch KV da Rocha Nogueira A | 2009 | J Clin Epidemiol2009，5，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员