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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Effects of postmortem aging time, animal age, and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | HUFF-LONERGAN E PARRISH F C ROBSON R M | 1995 | Anim Sci1995，73，4： | 1 |
| 3 | Direct and indirect effects of solar ultraviolet-B radiation on longterm decomposition显示文摘 | Pancotto V A Sala O E Robson T M | 2005 | Glob Chang Biol2005，，11： | 1 |
| 4 | Direct and indirect effects of solar ultraviolet-B radiation on long-term decomposition 显示文摘 | PANCOTTO V A SALA O E ROBSON T M | 2005 | Global Change Biology2005，11，： | 1 |
| 5 | Leaf emergence, tiller growth and apical development of nitrogen deficient spring wheat显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 6 | Effects of postmortem aging time, animal age, and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | HUFF-LONERGAN E PARRISH F C ROBSON R M | 1995 | Animal Science1995，73，： | 1 |
| 7 | Evaluation of germline PTEN mutations in endometrial cancer patients 显示文摘 | Black D Bogomolniy F Robson M E | 2005 | Gynecol Oncol2005，96，1： | 1 |
| 8 | Potential use of the alkaline comet assay as a predictor of bladder tumor response to radiation显示文摘 | McKeown S R Robson T Price M E | 2003 | Br J Cancer2003，89，12： | 1 |
| 9 | Leaf emergence, tiller growth, and apical development of nitrogen-dificient spring wheat 显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 10 | EVects of postmortem aging time,animal age,and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | Huff-Lonergan E Parrish F C Robson R M | 1995 | Jour- nal of Animal Science1995，73，4： | 1 |
| 11 | Effects of postmortem aging time,animal age,and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | Huff-Lonergan E F C Parrish Jr Robson R M | 1995 | Journal of Animal Science1995，73，： | 1 |
| 12 | Leaf emergence,tiller growth and apical development of nitrogen deficient spring wheat显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，： | 1 |
| 13 | Effects of postmortem aging time, animal age and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | HUFF-LONERGAN E PARRISH J F C ROBSON R M | 1995 | Journal of Animal Science1995，73，： | 1 |
| 14 | The manage ment of rhinitis in patients with functional epiphora :a random ized controlled crossover trial显示文摘 | McNeill E J Kubba H Bearn M A Robson A K | 2005 | Am J Rhinol2005，19，： | 1 |
| 15 | Direct and indirect effects of solar ultraviolet-B radiation on long-term decom- position 显示文摘 | PANCOTYO V A SALA O E ROBSON T M | 2005 | Global Change Biol2005，11，： | 1 |
| 16 | Effects of postmortem aging time, animal age, and sex on degradation of titin and nebulin in bovine longissimus muscle显示文摘 | Huff-Lonergan E Parrish F C Robson R M | 1995 | Journal of Animal Science1995，73，4： | 1 |
| 17 | Acute vassar rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity显示文摘 | Gollackner B Goh S K Qawi I Buhler L Knosalla C Daniel S Kaczmarek E Awwad M Cooper D K Robson S C | 2004 | Transplantation2004，77，11： | 1 |
| 18 | Leaf emergence, tiller growth, and apical development of nitrogen-deffcient spring wheat 显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crops Science1993，33，： | 1 |
| 19 | Leaf emergence,tiller growth and apical development of Nitrogen-deficient spring wheat显示文摘 | LONGNECKER N E KIRBY E J M ROBSON A D | 1993 | Crop Science1993，33，： | 1 |
| 20 | Oral poly(ADPribose) polymerase inhibitor olaparib in patients with BRCAI or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial 显示文摘 | TUTT A ROBSON M GARBER J E | 2010 | Lancet2010，376，9737： | 1 |
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