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| 1 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 2 | Immunological homologies between wheat gluten and starch granule proteins显示文摘 | Skerritt J H Frend A J Robson L G | 1990 | J Cereal Sci1990，，12： | 2 |
| 3 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 4 | The effect of phosphorus on the formation of hyphae in soil by vesicular mycorrhizal fungus ,Glomus fasciculatum显示文摘 | Abbott L K Robson A D Boer G | 1984 | New phytologist1984，97，： | 1 |
| 5 | Isolation and partial characterization of the Streptococcus mutans type AⅡ lantibiotic mutacin K8 显示文摘 | ROBSON C L WESCOMBE P A KLESSE N A | 2007 | Microbiology2007，153，5： | 1 |
| 6 | Epidural analgesia need not increase operative delivery rates显示文摘 | Impey L MacQuillan K Robson M | 2000 | Am J Obstet Gynecol2000，182，： | 1 |
| 7 | Cloning,sequencing and characterization of the hydrogenase-encoding structural genes (hoxK and hoxG) from Azotobacter vinelandii显示文摘 | Menon A L Stults L W Robson R L | 1990 | Gene1990，96，1： | 1 |
| 8 | Identification of a human ribosomal protein mRNA with increased expression in colorectal tumors显示文摘 | Chester KA Robson L Begent RHJ | 1989 | Biochim Biophys Acta1989，1009，： | 1 |
| 9 | Radiosensitization of colon cancer cell lines by docetaxd: Mechanisms of action 显示文摘 | DunneA L MothersillC Robson T | 2004 | Oncol Res2004，14，9： | 1 |
| 10 | Wnt signaling regulates myogenic differentiation in the developing avian wing 显示文摘 | Anakwe K Robson L Hadley J | 2003 | Development2003，130，8： | 1 |
| 11 | Emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada 显示文摘 | Zhang X M Diamond M L Robson M | 2011 | Environmental Science & Technology2011，45，8： | 1 |
| 12 | MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis显示文摘 | Farrugia ME Robson MD Clover L | 2006 | Brain2006，29，6： | 1 |
| 13 | Effect phosphorus on the formation of hyphae in soil by vesicular mycorrhizal fun- gus, Glornus fasciculatum 显示文摘 | Abbott L K Robson A D De Boer G | 1984 | New Phytologist1984，97，： | 1 |
| 14 | A new suberate to measure protection factors throughout the ultraviolet spectrum 显示文摘 | Diffey B L Robson J | 1989 | Journal of the Society of Cosmetic Chemists1989，40，3： | 1 |
| 15 | Model for grain evolution during friction stir welding of aluminium alloys显示文摘 | ROBSON J D CAMPBELL L | 2010 | Science and Tech- nology of Welding and Joining2010，15，2： | 1 |
| 16 | Attenuation of virus diarrhea virus(strain Oregon C24V) for vaccine purposes显示文摘 | COGGINS L GILLESPIE J H ROBSON D S | 1961 | Cornell Vet1961，54，： | 1 |
| 17 | The effect of soil disturbance on vesicular-arbuscular mycorrhizal fungi in soil from different vegetation types显示文摘 | JASPER D A ABBOTT L K ROBSON A D | 1991 | New Phytologist1991，118，： | 1 |
| 18 | Seclection of inoculant vesicular-arbuscular mycorrhizal fungi显示文摘 | ABBOTT L K ROBSON A K D GAZEY C D | 1992 | Methods in the Microbiology1992，24，： | 1 |
| 19 | Effect of renal impairment on the pharmacokinetics of the GLP-1 analogueliraglutide 显示文摘 | Jacobsen L V Hindsberger C Robson R | 2009 | BrJ ClinPharmacol2009，68，6： | 1 |
| 20 | The effect of phosphoruson the formation of hyphae in soil by the vesicular arbuscularmycorrhizal fungus,Glomus fasciculatum显示文摘 | ABBOTT L K ROBSON A D DEBOER G | 1984 | New Phytologist1984，97，： | 1 |
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