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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | The ultraviolet sensitivity of Kevlar 149 and teehnora fibres 显示文摘 | DOBB M G ROBSON R M ROBERTYS A H | 1993 | Journal of Materials Science1993，28，3： | 1 |
| 3 | Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-con- cept trlal显示文摘 | Tutt A Robson M C arber JE | 2010 | Lancet2010，376，9737： | 1 |
| 4 | Direct and indirect effects of solar ultraviolet-B radiation on longterm decomposition显示文摘 | Pancotto V A Sala O E Robson T M | 2005 | Glob Chang Biol2005，，11： | 1 |
| 5 | Direct and indirect effects of solar ultraviolet-B radiation on long-term decomposition 显示文摘 | PANCOTTO V A SALA O E ROBSON T M | 2005 | Global Change Biology2005，11，： | 1 |
| 6 | Oral poly(ADP-ribose) polymer- ase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 7 | Major ion concentrations and inorganic carbon chemistry of the Humber river 显示文摘 | Neal C Robson A J Harrow M | 1997 | Sci Total Environ1997，，： | 1 |
| 8 | Leaf emergence, tiller growth and apical development of nitrogen deficient spring wheat显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 9 | Effects of granulocyte-macrophage colony-stimulating factor on wound contraction显示文摘 | Robson M Kucukcelebi A Carp SS | 1994 | Eur J Clin Microbiol Infect Dis1994，132，： | 1 |
| 10 | Oral poly(ADP-ribose) poly- merase inhibitor olaparib in patients with BRCA1 or BRCA2 muta- tions and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lan- cet2010，376，9737： | 1 |
| 11 | Oral poly(ADP-ri- bose) polymerase inhibitor olaparib in patients with BRCAI or BRCA2 mutations and advanced breast can- cer: a proof-of-concept trial显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 12 | Effects of granulocyte-macrophage colony-stimulating factor on wound contraction显示文摘 | ROBSON M KUCUKCELEBI A CARP S S | 1994 | Eur J Clin Microbiol Infect Dis1994，13，2： | 1 |
| 13 | Oral poly ( ADP-ribose ) poly- merase inhibitor olaparib in patients with BRCA1 or BRCA2 muta- tions and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 14 | Solar UV-B influences microfaunal community composition in a Tierra del Fuego peatland显示文摘 | Robson T M Pancotto V A Scopel A L | 2005 | Soil Biol Biochem2005，，37： | 1 |
| 15 | Oral poly(ADP-ribose)pol- ymerase inhibitor olaparib in patients with BRCA1 or BRCA2 muta- tions and advanced breast caneer:a proof of concept trial显示文摘 | Tutt A Robson M Garber JE et ai | 2010 | Lan- cet2010，376，9737： | 1 |
| 16 | Oral poly (ADP-ribose)polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer:a proof-of-concept trial显示文摘 | Tutt A Robson M Garber JE | | 0，，： | 1 |
| 17 | Solar UV-B influences microfaunal community composition in a Tierra del Fuego peatland 显示文摘 | ROBSON T M PANCOTTO V A SCOPEL A L | 2005 | Soil Biology & Biochemistry2005，37，12： | 1 |
| 18 | 'Phase Ⅱ trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer'显示文摘 | Tutt A Robson M Garber JE | 2009 | J Clin Oncol2009，27，： | 1 |
| 19 | Oral poly (ADP-ribose) polymerase inhibitor olaparib in patients with BRCAI or BRCA2 mutations and advanced breast cancer :a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 20 | Leaf emergence, tiller growth, and apical development of nitrogen-dificient spring wheat 显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
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