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| 1 | Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances显示文摘A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). | Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili Antonina Mosca Roberto Cirilli | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 2 | Agent directed HLA simulation for complex supply chain modeling显示文摘 | Agostino G Bruzzone Roberto Mosca | 2005 | Simulation2005，81，9： | 1 |
| 3 | Takotsubo Cardiomyopathy: Overview显示文摘 | Eduardo Bossone Gianluigi Savarese Francesco Ferrara Rodolfo Citro Susanna Mosca Francesca Musella Giuseppe Limongelli Roberto Manfredini Antonio Cittadini Pasquale Perrone Filardi | 2012 | Heart Failure Clinics2012，，： | 1 |
| 4 | Detection of biliary complications after orthotopic liver transplantation with MR cholangiography显示文摘 | Piero Boraschi Giovanni Braccini Roberto Gigoni Giorgio Sartoni Emanuele Neri Franco Filipponi Franco Mosca Carlo Bartolozzi | 2001 | Magnetic Resonance Imaging2001，，8： | 1 |
| 5 | Expanding Indications for TIPSS: Portal Decompression Before Elective Oncologic Gastric Surgery in Cirrhotic Patients显示文摘 | Gabriele Catalano Lucio Urbani Paolo De Simone Luca Morelli Laura Coletti Roberto Cioni Giancarlo Matocci Franco Mosca Franco Filipponi | 2005 | Journal of Clinical Gastroenterology2005，，10： | 1 |
| 6 | Splenic vein thrombosis complicated by massive gastric bleeding: treatment with arterious embolization显示文摘 | Covarelli Piero Badolato Marco Boselli Carlo Noya Giuseppe Cristofani Roberto Mosca Stefano Tei Francesco | 2008 | The American Surgeon2008，，2： | 1 |
| 7 | First-line pazopanib in patients with advanced non-clear cell renal carcinoma:An Italian case series显示文摘BACKGROUND Non-clear cell(ncc)metastatic renal-cell carcinoma(RCC)has dismal results with standard systemic therapies and a generally worse prognosis when compared to its clear-cell counterpart.New systemic combination therapies have emerged for metastatic RCC(mRCC),but the pivotal phase III trials excluded patients with nccRCC,which constitute about 30%of metastatic RCC cases.AIM To provide a piece of real-life evidence on the use of pazopanib in this patient subgroup.METHODS The present study is a multicenter retrospective observational analysis aiming to assess the activity,efficacy,and safety of pazopanib as first-line therapy for advanced nccRCC patients treated in a real-life setting.RESULTS Overall,48 patients were included.At the median follow-up of 40.6 mo,the objective response rate was 27.1%,the disease control rate was 83.3%,and the median progression-free survival and overall survival were 12.3(95%confidence interval[CI]:3.6-20.9)and 27.7(95%CI:18.2-37.1)mo,respectively.Grade 3 adverse events occurred in 20%of patients,and no grade 4 or 5 toxicities were found.CONCLUSION Pazopanib should be considered as a good first-line option for metastatic RCC with variant histology. | Sebastiano Buti Melissa Bersanelli Francesco Massari Ugo De Giorgi Orazio Caffo Gaetano Aurilio Umberto Basso Giacomo Carteni Claudia Caserta Luca Galli Francesco Boccardo Giuseppe Procopio Gaetano Facchini Giuseppe Fornarini Alfredo Berruti Elena Fea Emanuele Naglieri Fausto Petrelli Roberto Iacovelli Camillo Porta Alessandra Mosca | 2021 | World Journal of Clinical Oncology2021，12，11： | 0 |
| 8 | 知识就是力量——具有高性能塔盘的脱异丁烷塔的脱瓶颈改造显示文摘优化工艺设备的性能,需要对设备本身和设备所服务的工艺具有相当深刻的了解。分裂精馏塔包括再沸器、换热器和泵,以及分馏塔盘和分配器。本文描述了在不影响效率的情况下最大化精馏塔能力的改造工程,改造的基础是在道达尔炼油公司(比利时安特卫普市)的脱异丁烷塔内使用Sulzer Chemtech公司的VGPlus塔盘。 | Giuseppe Mosca Gitta Van Heme Roberto Tocco Bruno Lestrade | 2006 | 流程工业2006，，7： | 0 |
| 9 | Density of states characterization of TiO_(2) films deposited by pulsed laser deposition for heterojunction solar cells显示文摘The application of titanium dioxide(TiO_(2))in the photovoltaic(PV)field is gaining traction as this material can be deployed in doping-free heterojunction solar cells with the role of electron selective contact.For modeling-based optimization of such contact,knowledge of the titanium oxide defect density of states(DOS)is crucial.In this paper,we report a method to extract the defect density through nondestructive optical measures,including the contribution given by small polaron optical transitions.The presence of both related to oxygen-vacancy defects and polarons is supported by the results of optical characterizations and the evaluation of previous observations resulting in a defect band fixed at 1 eV below the conduction band edge of the oxide.Solar cells employing pulsed laser deposited-TiO_(2)electron selective contacts were fabricated and characterized.The J-V curve of these cells showed,however,an S-shape,then a detailed analysis of the reasons for such behavior was carried out.We use a model involving the series of a standard cell equivalent circuit with a Schottky junction in order to explain these atypical performances.A good matching between the experimental measurements and the adopted theoretical model was obtained.The extracted parameters are listed and analyzed to shed light on the reasons behind the low-performance cells. | Daniele Scire Roberto Macaluso Mauro Mosca Maria Pia Casaletto Olindo Isabella Miro Zeman Isodiana Crupi | 2022 | Nano Research2022，15，5： | 0 |
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