|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Mean platelet volume during coagulase - negarfive staphylococcal sepsis in neonates显示文摘 | Oconnor T A Ringer K M Gaddis M L | 1980 | Pediatr Res1980，14，2： | 1 |
| 3 | The free radical scavenger (alpha)-phenyl-Tert-butyl nitrone aggravates hippecam- pal apeptesis and learning deficits in experimental pneumocoecal meningitis显示文摘 | Loeffler JM Ringer R Hablutzel M | 2001 | J Infect Dis2001，183，2： | 1 |
| 4 | Risk factors for infusion-related phlebitis with small peripheral venous catheters:a randomized controlled trial显示文摘 | Maki DG Ringer M | 1991 | Ann Intern Med1991，114，： | 1 |
| 5 | Risk factor for infusion-related phlebitis with small peripheral venous catheters:Arandomized controlled trail显示文摘 | Maki DG Ringer M | | 0，，： | 1 |
| 6 | Effects of supplemental dietary copper on growth,reproductive performance and kit survival of standarddark mink and acute toxicity of copper in minks 显示文摘 | AULERICH R J RINGER R K BLEAVINS M R etal | 1982 | Journal of Animal Science1982，55，2： | 1 |
| 7 | Prospective randomized trial of povidone-iodine alcohol,and chlorhexidine for prevention of infection associated with central venous and arterial catheters显示文摘 | Maki DG Ringer M Alvarado CJ | | 0，，： | 1 |
| 8 | Dverexpressi0n of HSP70 after induction of experimental stroke protects neurons from ischemic elamage显示文摘 | Hoehu B Ringer T M Xu L | 2001 | J Cereb Blood Flow Metab2001，21，11： | 1 |
| 9 | Introducing a strain-hardening capability to improve the ductility of bulk metallic glasses via severe plastic deformation 显示文摘 | WANG Y B QU D D WANG W H CAO Y LIAO X Z KAWASAKI M RINGER S P SHAN Z W LANGDON T G SHEN J | 2012 | Acta Mater2012，60，： | 1 |
| 10 | Risk factors for infusion-related phlebitis with small peripheral venous cathters 显示文摘 | Maki DG Ringer M | 1991 | Ann Intern Med1991，114，10： | 1 |
| 11 | Atomistic mechanisms of adhesive contact formation and interracial processes显示文摘 | Landman U Luedtke W D Ringer E M | 1992 | Wear1992，153，1： | 1 |
| 12 | Prospective randomized trial of povidone-iodine alcohol,and chlorhexidine for prevention of infection associated with centralvenous and arterial catheters显示文摘 | Maki DG Ringer M Alvarado CJ | 1991 | Lancet1991，338，： | 1 |
| 13 | Effects of supplemental dietary copper on growth,reproductive performance and kit survival of standard dark mink and the acute toxicity of copper to mink显示文摘 | AULERICH R J RINGER R K BLEAVINS M R | 1982 | Journal of Animal Science1982，55，2： | 1 |
| 14 | A procedure for automatically estimating model parameters in optical motion capture 显示文摘 | RINGER M LASENBY J | 2004 | Image and Vision Computing2004，22，10： | 1 |
| 15 | The effect of multiple subsitituents on sandwich and T- shaped pi-pi interactions 显示文摘 | RINGER A L SINNOKROT M O LIVELY R P | 2006 | Chemistry-A European Journal2006，12，14： | 1 |
| 16 | High-pressure torsion induced microstructural evolution in a hexagonal close-packed Zr alloy 显示文摘 | WANG Y B LOUIE M CAO Y LIAO X Z LI H J RINGER S P ZHU Y T | 2010 | Scripta Mater2010，62，： | 1 |
| 17 | Atomistic mechanisms of adhesive contact formation and interfacial processes显示文摘 | Landman U Luedtke W D Ringer E M | 1992 | Wear1992，153，1： | 1 |
| 18 | A procedure for automatically estimating model parameters in optical motion capture显示文摘 | Ringer M Lasenby J | 2004 | Image and Vision Computing2004，22，： | 1 |
| 19 | A procedure for automatically estimating model parameters in optical motion capture 显示文摘 | Ringer M Lasenby J | 2004 | Image and Vision Computing2004，22，： | 1 |
| 20 | Risk factors for infusionrelated phlebitis with small peripheral venous catheters 显示文摘 | Maki D Ringer M | 1991 | Annals of Internal Medicine1991，114，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员