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272篇 您的检索式：作者名="Ringe B"

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	题名	作者	年代	出处	被引量
1	Chemical conjugation of a novel antibody interleukin 2 immunoconjugate against c erbB 2 product显示文摘Objective To develop a new chemical method to produce a monoclonal antibody (MoAb) 520C9/recombinant human interleukin 2 (rhIL 2) conjugate Methods MoAb 520C9 reactive with the protooncogene c erbB 2 product P185 was chemically conjugated with rhIL 2 by using a simple two step method First, the rhIL 2 was activated by Sulfosuccinimidyl 4 [N maleimidomethyl] cyclohexane 1 carboxylate, a heterobifunctional linker, and N succinimidyl s acetylthioacetate was introduced onto 520C9 Then SATA on the 520C9 was reacted with the maleimide group on the activated rhIL 2 to generate 520C9 rhIL 2 immunoconjugate Results The immunoconjugate retained the antigen binding activity compared to the respective native antibody as determined by an indirect live cell binding assay The immunoconjugate also possessed IL 2 activity as measured by the standard CTLL 2 cells proliferation assay and the stimulation of human peripheral blood mononuclear cells (PBMCs) into lymphokine activated killer cells Conclusion Our method of conjugation of rhIL 2 to 520C9 preserves the binding activity of the antibody and the cytokine function of IL 2 This simple and efficient method of conjugation should be applicable to other types of MoAbs and recombinant	李君 Sharon E Lee Marie Belciug David B Ring Cheuk S Kwok	2000	Chinese Medical Journal2000，，2：	3
2	Total hepatectomy and liver transplantation as two-stage procedure显示文摘	Ringe B Lubbe N Kuse E	1993	Ann Surg1993，218，1：	1
3	Transplantation einer spenderleber aweie mpfanger (splitting-transplantation) eine neue methode in der weiterentwicklung derlebersegment reansplantation显示文摘	Pichl mayr R Ringe B Gubernatis G	1988	Langenbecks Arch Chir1988，104，：	1
4	Transplantation of a donor liver to 2 recipients (splitting transplantation):a new method in the further development of segmental liver transplantation显示文摘	Pichlmayr R Ringe B Gubernatis G		0，，02：	1
5	REDIA-impacts of DRG introduction in the acute sector on medical rehabih'tation显示文摘	von Eif W Sch ii ring S Greitemann B	2011	Die Rehabilitation2011，50，4：	1
6	Combined dorsal and volar plate fixation of complex fractures of the distal part of the radius显示文摘	RING D PROMMERSBERGER K JUPITER J B	2004	J Bone Joint Surg Am2004，86，8：	1
7	Wrighton SA comparative metabolic capabilities of CYP3A4, CYP3AS, and CYP3A7 显示文摘	Williams JA Ring B J Cantrell Ve	2002	Drug Metab Dispos2002，30，：	1
8	Transplantation of a donor liver to 2 recipients (splitting transplantation)-a new method in the further development of segmental liver transplantation显示文摘	Piehlmayr R Ringe B Gubernatis G	1988	Langenbecks Arch Chir1988，373，2：	1
9	Extended right liver grafts obtained by an ex situ split can be used safely for primary and secondary transplantation with acceptable biliary morbidity显示文摘	Takebe A Schrem H Ringe B		0，，07：	1
10	Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo 显示文摘	RING D B JOHNSON K W HENRIKSEN E J	2003	Diabetes2003，52，3：	1
11	Bile duct injury as part of diagnostic criteria for liver allograft rejection 显示文摘	Ringe B Cohnert TR	1988	Hum Pathol1988，20，2：	1
12	Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity显示文摘	Delorme B Ringe J Pontikoglou C	2009	Stem Cells2009，27，5：	1
13	Systemically and topi2cally administered leptin both accelerate wound healing in diabetic ob/ob mice显示文摘	Ring B D Scully S Davis C R	2000	Endocrinology2000，141，：	1
14	Posterior dislocation of the elbow with fractures of the radial head and coronoid显示文摘	Ring D Jupiter J B Zilberfarb J	2002	J Bone Joint Surg Am2002，84，4：	1
15	Posterior dislocation of the el-bow with fractures of the radial head and coronoid 显示文摘	Ring D Jupiter J B Zilberfarb J	2002	J BoneJoint Surg Am2002，84，4：	1
16	Assessment of spatial neglect using computerised feature and conjunction visual search tasks显示文摘	EREZ A B KATZ N RING H	2009	Neumpsychol Rehabil2009，19，5：	1
17	Vofar Barton' s fractures with concomitant dorsal fracture in older patients 显示文摘	Harness N Ring D Jupiter J B	2004	J Hand Surg2004，29，3：	1
18	Resection of synchronous liver metastases from colorectal cancer显示文摘	Vogt P Raad R Ring B	1991	Word J Surg1991，15，：	1
19	Specific lineage-prinming of bone marrow mcsenchy-mal stem ceils provides the molecular framework for their plasticity 显示文摘	Delorme B Ringe J Pontikoglou C	2009	Stem Ceils2009，27，5：	1
20	The oral DPP-4 inhibitor lina- gliptin significantly lowers HbAlc after 4 weeks of treatment in pa- tients with type 2 diabetes mellitus 显示文摘	Forst T Uhlig-Lasker B Ring A	2011	Diabetes Obes Metab2011，13，6：	1

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